scholarly journals Serum Levels of the Proinflammatory Cytokines Interleukin-1 Beta (IL-1β), IL-6, IL-8, IL-10, Tumor Necrosis Factor Alpha, and IL-12(p70) in Malian Children with Severe Plasmodium falciparum Malaria and Matched Uncomplicated Malaria or Healthy Controls

2004 ◽  
Vol 72 (10) ◽  
pp. 5630-5637 ◽  
Author(s):  
K. E. Lyke ◽  
R. Burges ◽  
Y. Cissoko ◽  
L. Sangare ◽  
M. Dao ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Cerebral Malaria ◽  
Severe Malaria ◽  
Uncomplicated Malaria ◽  
Tumor Necrosis ◽  
Severe Anemia ◽  
Healthy Controls ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months to 14 years residing in Bandiagara, Mali, were matched to cases of uncomplicated malaria and healthy controls. Using modified World Health Organization criteria for defining severe malaria, we identified 100 cases of cerebral malaria (coma, seizure, and obtundation), 17 cases of severe anemia (hemoglobin, <5 g/dl), 18 cases combined cerebral malaria with severe anemia, and 92 cases with hyperparasitemia (asexual trophozoites, >500,000/mm3). Significantly elevated levels (given as geometric mean concentrations in picograms/milliliter) of interleukin-6 (IL-6; 485.2 versus 54.1; P = <0.001), IL-10 (1,099.3 versus 14.1; P = <0.001), tumor necrosis factor alpha (10.1 versus 7.7; P = <0.001), and IL-12(p70) (48.9 versus 31.3; P = 0.004) in serum were found in severe cases versus healthy controls. Significantly elevated levels of IL-6 (485.2 versus 141.0; P = <0.001) and IL-10 (1,099.3 versus 133.9; P = <0.001) were seen in severe malaria cases versus uncomplicated malaria controls. Cerebral malaria was associated with significantly elevated levels of IL-6 (754.5 versus 311.4; P = <0.001) and IL-10 (1,405.6 versus 868.6; P = 0.006) compared to severe malaria cases without cerebral manifestations. Conversely, lower levels of IL-6 (199.2 versus 487.6; P = 0.03) and IL-10 (391.1 versus 1,160.9; P = 0.002) were noted in children with severe anemia compared to severe malaria cases with hemoglobin at >5 g/dl. Hyperparasitemia was associated with significantly lower levels of IL-6 (336.6 versus 602.1; P = 0.002). These results illustrate the complex relationships between inflammatory cytokines and disease in P. falciparum malaria.

scholarly journals Severe imported malaria in a Serbian referral center

2019 ◽  
Vol 76 (5) ◽  
pp. 470-475
Author(s):  
Jasmina Poluga ◽  
Uros Karic ◽  
Zorica Dakic ◽  
Natasa Katanic ◽  
Lidija Lavadinovic ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Severe Malaria ◽  
Disease Severity ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
World Health ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Serum Tumor Necrosis

Background/Aim. The World Health Organization estimates that 3.2 billion people are at a risk of being infected with malaria. Thus, the adequate diagnostic protocols for malaria, especially those aimed at determining disease severity, are paramount both in endemic and non-endemic setting. The aim of this study was to identify the demographic, parositological, clinical and laboratory characteristics associated with severe malaria in a non-endemic settings. Methods. We analyzed 22 patients with severe malaria and compared their clinical and laboratory findings with those of the patients with non-severe malaria in a search of predictors of disease severity. All patients were treated at the Infectious and Tropical Diseases University Hospital, Clinical Centre of Serbia in Belgrade, Serbia from 2000 to 2010. Results. The average age of patients with with severe malaria was 44.86 ? 12.33 years and men predominated (95.45%). The patients with severe malaria were infected Plasmodium falciparum (P. falciparum) significantly more frequently compared with those with non-severe disease (p =0.047). Jaundice was the most commonly observed feature of severe malaria, followed by anemia and renal failure. The multifactor analysis of variance showed that thrombocytopenia (p = 0.05) and high serum tumor necrosis factor-alpha levels (p = 0.02) were significantly associated with the disease severity. Conclusion. A high index of suspicion for malaria should be maintained when evaluating febrile patients returning from the malaria endemic regions. The elevated serum tumor necrosis factor-alpha levels and thrombocytopenia are associated with severe malaria in non-endemic settings.

scholarly journals Expression of Tumor Necrosis Factor Alpha-Induced Protein 3 mRNA in Peripheral Blood Mononuclear Cells Negatively Correlates with Disease Severity in Psoriasis Vulgaris

2012 ◽  
Vol 19 (12) ◽  
pp. 1938-1942 ◽  
Author(s):  
Xuebing Jiang ◽  
Hongqing Tian ◽  
Yuchen Fan ◽  
Jie Chen ◽  
Yonghong Song ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Psoriasis Vulgaris ◽  
Mononuclear Cells ◽  
Healthy Controls ◽  
Peripheral Blood Mononuclear ◽  
Necrosis Factor Alpha ◽  
Tnfaip3 Gene ◽  
Severe Group ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACTPsoriasis vulgaris is considered a chronic inflammatory disease, but its immunopathogenesis has not been well understood. The tumor necrosis factor alpha-induced protein 3 (TNFAIP3) gene functions in negative-feedback regulation of inflammation, and its single nucleotide polymorphism is associated with psoriasis. However, the relationship between the expression level of the TNFAIP3 gene in immune cells and psoriasis is not known so far. In the present study, TNFAIP3 mRNA expression levels in peripheral blood mononuclear cells from 44 patients with psoriasis vulgaris and 30 healthy controls were determined using real-time reverse transcription-PCR analysis. We found that expression of TNFAIP3 mRNA in all patients negatively correlated with the psoriatic area and severity index (PASI) (r= −0.5126;P= 0.0004) as well as with the percentage of body surface area affected by psoriasis (r= −0.5013;P= 0.0005). Patients were divided into mild and severe groups based on the mean PASI score. Expression of TNFAIP3 mRNA in the mild group was higher than that in the severe group (P= 0.0064). Moreover, compared with that in healthy controls, the expression of TNFAIP3 mRNA in the mild group was significantly upregulated (P= 0.0004), but the expression of TNFAIP3 mRNA in the severe group was not. These results suggest that the expression level of TNFAIP3 plays an important role in the pathology of psoriasis vulgaris and that the loss of upregulation of TNFAIP3 expression may contribute to the severity of psoriasis vulgaris.

scholarly journals Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
N. Konuk ◽  
I. O. Tekın ◽  
U. Ozturk ◽  
L. Atik ◽  
N. Atasoy ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Necrosis Factor Alpha ◽  
Compulsive Disorder ◽  
Factor Alpha ◽  
Necrosis Factor

Aim. Recent research implicated place of an immune mechanism in the pathophysiology of obsessive-compulsive disorder (OCD). Despite increasing evidence involvement of cytokine release in OCD, results of the studies are inconsistent. The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in OCD patients.Methods. Plasma concentrations of TNF-αand IL-6 were measured in 31 drug-free outpatients with OCD, and 31-year age and sex-matched healthy controls. TNF-αand IL-6 concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA).Results. Both TNF-αand IL-6 levels showed statistically significant increases in OCD patients compared to controls (P<.000,P<.001, resp.). In addition, the age of onset was negatively correlated with TNF-αlevel (r=−.402,P=.025) and duration of illness was weakly correlated with IL-6 levels(r:.357;P:.048)in patients group.Conclusion. OCD patients showed increases in TNF-αand IL-6 levels compared to the healthy controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of OCD.

scholarly journals Erythropoietin Levels Increase during Cerebral Malaria and Correlate with Heme, Interleukin-10 and Tumor Necrosis Factor-Alpha in India

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158420 ◽  
Author(s):  
Esther Dalko ◽  
Nicolas Tchitchek ◽  
Laurent Pays ◽  
Fabien Herbert ◽  
Pierre-André Cazenave ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Cerebral Malaria ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Interleukin 10 ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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