scholarly journals Identification of Novel Sinorhizobium meliloti Mutants Compromised for Oxidative Stress Protection and Symbiosis

2006 ◽  
Vol 189 (5) ◽  
pp. 2110-2113 ◽  
Author(s):  
Bryan W. Davies ◽  
Graham C. Walker
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Medicago Sativa ◽  
Host Plant ◽  
Sinorhizobium Meliloti ◽  
Cellular Processes ◽  
Stress Protection ◽  
Oxidative Stress Protection

ABSTRACT Employing a novel two-part screen, we identified Sinorhizobium meliloti mutants that were both sensitive to hydrogen peroxide and symbiotically defective on the host plant Medicago sativa. The mutations affect a wide variety of cellular processes and represent both novel and previously identified genes important in symbiosis.

Caveolin-1 promotes radioresistance in rhabdomyosarcoma through increased oxidative stress protection and DNA repair

2021 ◽  
Vol 505 ◽  
pp. 1-12
Author(s):  
Silvia Codenotti ◽  
Francesco Marampon ◽  
Luca Triggiani ◽  
Marco Lorenzo Bonù ◽  
Stefano Maria Magrini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Repair ◽  
Caveolin 1 ◽  
Stress Protection ◽  
Oxidative Stress Protection

scholarly journals Engineered EVs for Oxidative Stress Protection

2021 ◽  
Vol 14 (8) ◽  
pp. 703
Author(s):  
Anna Maria Tolomeo ◽  
Santina Quarta ◽  
Alessandra Biasiolo ◽  
Mariagrazia Ruvoletto ◽  
Michela Pozzobon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Extracellular Vesicles ◽  
Transgene Expression ◽  
Hepatoma Cell ◽  
Serine Protease Inhibitor ◽  
Protein Product ◽  
Hepatoma Cell Line ◽  
Cytoprotective Activity ◽  
Stress Protection ◽  
Oxidative Stress Protection

Extracellular vesicles (EVs) are increasingly studied as vectors for drug delivery because they can transfer a variety of molecules across biological barriers. SerpinB3 is a serine protease inhibitor that has shown a protective anti-apoptotic function in a variety of stressful conditions. The aim of this study was to evaluate protection from oxidative stress-induced damage, using extracellular vesicles that overexpress SerpinB3 (EVs-SB3) in order to enhance the effect of extracellular vesicles on cellular homeostasis. EVs-SB3s were obtained from HepG2 cells engineered to overexpress SerpinB3 and they revealed significant proteomic changes, mostly characterized by a reduced expression of other proteins compared with EVs from non-engineered cells. These EV preparations showed a significantly higher protection from H2O2 induced oxidative stress in both the hepatoma cell line and in primary cardiomyocytes, compared to cells treated with naïve EVs or SerpinB3 alone, used at the same concentration. In conclusion, the induction of SerpinB3 transgene expression results in the secretion of EVs enriched with the protein product that exhibits enhanced cytoprotective activity, compared with naïve EVs or the nude SerpinB3 protein.

Antioxidant activity and oxidative stress protection of duck proteins hydrolysates in SK-N-SH cells

2013 ◽  
Vol 4 (3) ◽  
pp. 476 ◽  
Author(s):  
Yuxing Guo ◽  
Daodong Pan ◽  
Zhen Wu ◽  
Chuanchuan Zhao ◽  
Jinxuan Cao
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Stress Protection ◽  
And Oxidative Stress ◽  
Oxidative Stress Protection

Alcohol-induced pancreatic oxidative stress: protection by phospholipid repletion

1999 ◽  
Vol 26 (5-6) ◽  
pp. 609-619 ◽  
Author(s):  
Semyon I. Aleynik ◽  
Maria Anna Leo ◽  
Maria K. Aleynik ◽  
Charles S. Lieber
Keyword(s):  
Oxidative Stress ◽  
Stress Protection ◽  
Oxidative Stress Protection

αB-crystallin is involved in oxidative stress protection determined by VEGF in skeletal myoblasts

2010 ◽  
Vol 49 (3) ◽  
pp. 374-382 ◽  
Author(s):  
Neri Mercatelli ◽  
Ivan Dimauro ◽  
Silvia Anna Ciafré ◽  
Maria Giulia Farace ◽  
Daniela Caporossi
Keyword(s):  
Oxidative Stress ◽  
Skeletal Myoblasts ◽  
Stress Protection ◽  
Αb Crystallin ◽  
Oxidative Stress Protection

Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC‐1α

2006 ◽  
Vol 20 (11) ◽  
pp. 1889-1891 ◽  
Author(s):  
Sara Borniquel ◽  
Inmaculada Valle ◽  
Susana Cadenas ◽  
Santiago Lamas ◽  
María Monsalve ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Transcriptional Coactivator ◽  
Mitochondrial Oxidative Stress ◽  
Stress Protection ◽  
Oxidative Stress Protection
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