Methicillin-Resistant Staphylococcus aureus Harboring mecC Still Eludes Us in East London, United Kingdom

ABSTRACT Reports of methicillin-resistant Staphylococcus aureus (MRSA) harboring the mecC gene have increased in the UK since first being described. To our diagnostic S. aureus multiplex PCR, a mecC primer set was designed and implemented, and then the prevalence in our patient population was investigated. Fewer than 1% of the clinical isolates possessed the mecC gene, confirming that mecA remains the dominant genetic determinant of MRSA in East London.

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Mupirocin resistance in methicillin-resistant Staphylococcus aureus clinical isolates in a Spanish hospital. Co-application of multiplex PCR assay and conventional microbiology methods

Diagnostic Microbiology and Infectious Disease ◽

10.1016/s0732-8893(02)00388-7 ◽

2002 ◽

Vol 43 (2) ◽

pp. 123-128 ◽

Cited By ~ 19

Author(s):

E Pérez-Roth ◽

F Claverie-Martı́n ◽

N Batista ◽

A Moreno ◽

S Méndez-Álvarez

Keyword(s):

Staphylococcus Aureus ◽

Multiplex Pcr ◽

Methicillin Resistant Staphylococcus Aureus ◽

Clinical Isolates ◽

Pcr Assay ◽

Methicillin Resistant ◽

Multiplex Pcr Assay ◽

Spanish Hospital ◽

Mupirocin Resistance

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erm(C) is the predominant genetic determinant for the expression of resistance to macrolides among methicillin-resistant Staphylococcus aureus clinical isolates in Greece

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkh197 ◽

2004 ◽

Vol 53 (5) ◽

pp. 814-817 ◽

Cited By ~ 33

Author(s):

I. Spiliopoulou

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Clinical Isolates ◽

Genetic Determinant ◽

Methicillin Resistant

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Investigation of methicillin-resistant Staphylococcus aureus among clinical isolates from humans and animals by culture methods and multiplex PCR

BMC Veterinary Research ◽

10.1186/s12917-018-1611-0 ◽

2018 ◽

Vol 14 (1) ◽

Cited By ~ 9

Author(s):

M. M. Rahman ◽

K. B. Amin ◽

S. M. M. Rahman ◽

A. Khair ◽

M. Rahman ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Multiplex Pcr ◽

Methicillin Resistant Staphylococcus Aureus ◽

Clinical Isolates ◽

Culture Methods ◽

Methicillin Resistant

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ReducedIn VitroActivity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.02015-15 ◽

2015 ◽

Vol 59 (12) ◽

pp. 7837-7841 ◽

Cited By ~ 11

Author(s):

I. J. Abbott ◽

A. W. J. Jenney ◽

C. J. Jeremiah ◽

M. Mirčeta ◽

J. P. Kandiah ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Clonal Complex ◽

Multidrug Resistant ◽

Clinical Isolates ◽

Methicillin Resistant ◽

Content Type ◽

Clinical Strains ◽

Resistant Phenotype

ABSTRACTA total of 421 methicillin-resistantStaphylococcus aureus(MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMérieux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, >1.0 μg/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P< 0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.

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