Performance of a Rapid Assay (Binax NOW) for Detection of Respiratory Syncytial Virus at a Children's Hospital over a 3-Year Period

Objectives of study are (1) to reinforce the national capacity for diagnosis and antibiogram of some infectious diseases causing severe acute respiratory infection (SARI) and (2) to build a network between hospital and laboratory for the diagnosis and surveillance of SARI in Yangon. This study is a crosssectional hospital- and laboratory-based descriptive study. A total of 825 samples including respiratory samples and blood samples from 511 children attending Yangon Children’s Hospital and Yankin Children’s Hospital from December 2014 to April 2016 for treatment of SARI were included. Identification and antibiotic sensitivity testing were done using Vitek 2. Out of 129 gram-negative bacilli (GNB), K. pneumoniae 32%, P. aeruginosa 18%, A. baumannii 13%, E. coli 9% were mostly isolated. Among 35 gram-positive cocci (GPC), S. aureus 42% and S. pneumoniae 6% were mostly isolated. Multidrug resistance rates were E. coli 100%, K. pneumoniae 95%, A. baumanii 82% and P. aeruginosa 17%. Extended-spectrum beta-latamase (ESBL)-producing K. pneumoniae and E. coli was 6 out of 10 tested organisms. Carbarpenemase-producing GNB and methicillin-resistant Staphylococcus aureus (MRSA) were 21% and 33%, respectively. Virology section tested 529 samples of 490 patients using the FTD33 Multiplex PCR method which can detect 33 pathogens including 20 viruses, 12 bacteria and 1 fungus. Out of 490 patients, 374 were PCR positive. Different types of samples including nasopharyngeal, throat, endotracheal and laryngeal swab, tracheal secretion and bronchoalveolar lavage, were tested. Out of 566 viruses, respiratory syncytial virus (RSV) (19.3%), rhinovirus (17.0%), parechovirus (14.3%), bocavirus (11.1%), adenovirus (10.2%), metapneumo-virus A and B (10.2%), parainfluenza virus (5.7%), enterovirus (3.0%), influenza A virus (2.8%), coronavirus (4%), parainfluenza virus (0.9%) and influenza C virus (0.4%) were detected. This study highlighted the etiological agents of bacteria, viruses and drug-resistant bacterial pathogens in SARI.

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Epidemiological and Clinical Features of Patients Suffering from Severe Pneumonia Caused by RSV in the Respiratory Center of the Viet Nam National Children's Hospital

Tạp chí Nghiên Cứu Và Thực Hành Nhi Khoa ◽

10.25073/jprp.v4i5.225 ◽

2020 ◽

Vol 4 (5) ◽

Author(s):

Thi Hong Hanh Le ◽

Thi Thu Hang Hoang ◽

Thi Le Nguyen ◽

Phuong Thanh Hoang ◽

Mai Lien Dang

Keyword(s):

Risk Factors ◽

Respiratory Distress ◽

Clinical Symptoms ◽

Age Groups ◽

Severe Pneumonia ◽

Respiratory Center ◽

Children's Hospital ◽

Children’S Hospital ◽

The Mean ◽

Syncytial Virus

Background/Purpose: Pneumonia is a common respiratory and life-threatening disease in pediatrics. Virus is an important cause of pneumonia in children, of which Respiratory syncytial virus (RSV) is the most common cause. The aim of this research is to access the clinical, epidemiological features and risk factors of patients suffering from RSV severe pneumonia. Methods: We studied 250 patients suffering from severe pneumonia caused by RSV from June 2019 to December 2019 in the Respiratory Center of the Vietnam National Children’s Hospital. Results: In Respiratory Center of our hospital, 3472 hospitalizations caused by pneumonia occurred in the last 6 months in 2019; 7.2% of these caused by RSV severe pneumonia. Pneumonia caused by RSV occurred most in male (66,7%), the rate of male/female = 2/1. The mean age was 4,94 ± 6,04 months. The prevalence of RSV in age groups is, respectively, as follows: less than 3 months (21,3%), from 3 months to 6 months (23,4%), from 6 months to 12 months (27%), from 12 months to 24 months (19%), over 2 years (9,3%). The most common symptoms which were accounted for over 80% were rhinorrhea, cough, wheeze, tachypnea and chest recession. The rate of admission increased sharply in December with 25.1% of cases. All hospitalized patients had respiratory distress symptoms with the frequent changes in blood gas, accounting for 59.2% of hypercapnia. The mean of hospitalization was 6,2 ± 7,4 days. Conclusion: the rate of RSV infection increased in the last 6 months in 2019. Most of patients who less than 1 year of age were admitted to hospital because of severe clinical symptoms and respiratory distress. Risk factors were related to the severity of RSV severe pneumonia were: premature, mal-nutrition, bronchopulmonary dysplasia.

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Passy-Muir Speaking Valve Use in a Children's Hospital: An Interdisciplinary Approach

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd18.2.76 ◽

2008 ◽

Vol 18 (2) ◽

pp. 76-86 ◽

Cited By ~ 2

Author(s):

Lauren Hofmann ◽

Joseph Bolton ◽

Susan Ferry

Keyword(s):

Tracheostomy Tube ◽

Pediatric Population ◽

Interdisciplinary Approach ◽

Extended Period ◽

Speech Development ◽

Tube Placement ◽

Background Information ◽

Speaking Valve ◽

Children's Hospital ◽

Children’S Hospital

Abstract At The Children's Hospital of Philadelphia (CHOP) we treat many children requiring tracheostomy tube placement. With potential for a tracheostomy tube to be in place for an extended period of time, these children may be at risk for long-term disruption to normal speech development. As such, speaking valves that restore more normal phonation are often key tools in the effort to restore speech and promote more typical language development in this population. However, successful use of speaking valves is frequently more challenging with infant and pediatric patients than with adult patients. The purpose of this article is to review background information related to speaking valves, the indications for one-way valve use, criteria for candidacy, and the benefits of using speaking valves in the pediatric population. This review will emphasize the importance of interdisciplinary collaboration from the perspectives of speech-language pathology and respiratory therapy. Along with the background information, we will present current practices and a case study to illustrate a safe and systematic approach to speaking valve implementation based upon our experiences.

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