scholarly journals Antibody to varicella-zoster virus after passive immunization against chickenpox

1978 ◽  
Vol 8 (6) ◽  
pp. 733-735
Author(s):  
A A Gershon ◽  
S Piomelli ◽  
M Karpatkin ◽  
E Smithwick ◽  
S Steinberg
Keyword(s):  
High Risk ◽  
Varicella Zoster Virus ◽  
Geometric Mean ◽  
Passive Immunization ◽  
Immune Serum ◽  
Immune Serum Globulin ◽  
Serum Globulin ◽  
Varicella Zoster ◽  
Antibody Titers ◽  
Immunofluorescence Antibody

Antibody titers to varicella-zoster virus were measured in varicella-susceptible immunocompromised children 48 h after they received either one of two lots of zoster immune globulin (ZIG) or a selected lot of immune serum globulin (ISG). Globulin was given to modify varicella in these children after exposure to varicella or zoster. Indirect immunofluorescence antibody titers (FAMA) of children after receipt of globulin ranged from less than 1:2 to 1:32. Geometric mean FAMA titers were highest after 1.2 ml of ISG per kg (FAMA titer 1:128) and 0.16 ml of ZIG lot A per kg (FAMA titer 1:1,024). Selected batches of ISG titering 1:128 or greater by FAMA, at a dose of 1.2 ml/kg, may be used to attempt to modify varicella in susceptible high-risk individuals when ZIG is not available.

Varicella zoster antibody titers after the administration of intravenous immune serum globulin or varicella zoster immune globulin

1984 ◽  
Vol 76 (3) ◽  
pp. 124-127 ◽  
Author(s):  
Sharon G. Paryani ◽  
Ann M. Arvin ◽  
Celine M. Koropchak ◽  
Alec E. Wittek ◽  
Michael D. Amylon ◽  
...  
Keyword(s):  
Immune Globulin ◽  
Immune Serum ◽  
Immune Serum Globulin ◽  
Serum Globulin ◽  
Varicella Zoster ◽  
Antibody Titers

Comparison of varicella zoster antibody titers in patients given intravenous immune serum globulin or varicella zoster immune globulin

1984 ◽  
Vol 105 (2) ◽  
pp. 200-205 ◽  
Author(s):  
S.G. Paryani ◽  
A.M. Arvin ◽  
C.M. Koropchak ◽  
M.B. Dobkin ◽  
A.E. Wittek ◽  
...  
Keyword(s):  
Immune Globulin ◽  
Immune Serum ◽  
Immune Serum Globulin ◽  
Serum Globulin ◽  
Varicella Zoster ◽  
Antibody Titers

THE EFFICACY OF FRAGMENTED IMMUNE SERUM GLOBULIN IN PASSIVE IMMUNIZATION

1966 ◽  
Vol 44 (3) ◽  
pp. 381-387 ◽  
Author(s):  
R. H. Painter ◽  
M. J. Walcraft ◽  
J. C. W. Weber
Keyword(s):  
Tetanus Toxin ◽  
Passive Immunization ◽  
Immune Serum ◽  
Immune Serum Globulin ◽  
Serum Globulin ◽  
Fab Fragment ◽  
Tetanus Antitoxin ◽  
Aged Material ◽  
Intravenous Injections ◽  
Fresh Preparation

The efficacy of an aged, fragmented preparation of immune serum globulin (human) as an agent for passive immunization was examined by comparing its performance in passive immunization with that of a fresh, unfragmented preparation. Guinea pigs passively immunized with the fresh preparation were protected against doses of tetanus toxin that were lethal to pigs which had received similar amounts of tetanus antitoxin as aged material.Monkeys passively immunized by intramuscular or intravenous injections of fresh immune serum globulin had levels of polio antibody in their serum which were consistently seven times higher than those produced by injection of the aged material. Urine collected from the monkeys treated with the aged material contained quantities of both polio and tetanus antibody as Fab fragment. After the intravenous injection of the aged material more than half of the injected antibody appeared in the urine within 24 hours.

Letter To The Editor

PEDIATRICS ◽  
1979 ◽  
Vol 63 (2) ◽  
pp. 348-348
Author(s):  
C. Henry Kempe ◽  
Anne A. Gershon
Keyword(s):  
High Risk ◽  
Varicella Zoster Virus ◽  
No Value ◽  
Immune Globulin ◽  
Passive Immunization ◽  
Practical Method ◽  
Active Immunization ◽  
Varicella Zoster ◽  
Hyperimmune Globulin ◽  
High Risk Children

The studies of Zaia et al demonstrating a practical method for preparation of hyperimmune globulin, varicella-zoster immune globulin (VZIG), for passive immunization against varicella are encouraging. Consequently, in the future, it should be possible to obtain VZIG for high-risk children who have known exposures to varicella-zoster virus. However, we believe that history has demonstrated that passive immunization is rarely a substitute for active immunization, and varicella is no exception to this rule. Passive immunization will be of no value if (1) persons are unaware that they were exposed or (2) they wait too long after exposure before notifying their physician.

Properties of Washed Human Platelets

1977 ◽  
Vol 37 (02) ◽  
pp. 291-308 ◽  
Author(s):  
Raelene L Kinlough-Rathbone ◽  
J Fraser Mustard ◽  
Marian A Packham ◽  
Dennis W Perry ◽  
Hans-Joachim Reimers ◽  
...  
Keyword(s):  
Major Effect ◽  
Human Platelets ◽  
Immune Serum ◽  
Immune Serum Globulin ◽  
Serum Globulin ◽  
Platelet Adherence ◽  
Low Concentrations ◽  
Induced Aggregation ◽  
Extensive Release ◽  
Protein Free Medium

SummaryWe have shown previously that washed human platelets resuspended in Tyrode solution containing albumin and apyrase maintain their disc shape and their ability to aggregate upon the addition of low concentrations of ADP, providing fibrinogen is added to the suspending medium. We have now examined their responses to other aggregating and release-inducing agents. Collagen, arachidonate, thrombin, immune serum globulin, the ionophore A 23, 187 and phytohaemagglutinin from Phaseolus vulgaris caused aggregation and release of granule contents. The response to adrenaline was variable. Serotonin caused the platelets to change shape but no aggregation or release occurred. Addition of a small amount of plasma was necessary for ristocetin-induced aggregation. Polylysine caused immediate platelet-to-platelet adherence with little or no release of granule contents. Responses to collagen or thrombin were greater in a modified medium containing magnesium but no calcium; in this medium, aggregation caused by ADP or polylysine was followed by the release of granule contents whereas these agents caused aggregation without release in a medium with both calcium and magnesium. When protein was omitted from the suspending medium, platelet aggregation in response to ADP was variable. In this medium, collagen and thrombin caused more extensive release than in the albumin-containing medium. Aggregation by polylysine was accompanied by release and extensive lysis in the protein-free medium. Thus, the composition of the final resuspending medium has a major effect on the responses of washed human platelets to aggregating agents.

Sign in / Sign up

Export Citation Format

Share Document