Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus

The disaster due to the novel coronavirus disease 2019 (COVID-19) around the world has made investigators enthusiastic about working on different aspects of COVID-19. However, although the pandemic of COVID-19 has not yet ended, it seems that COVID-19 compared to the other coronavirus infections (the Middle East Respiratory Syndrome [MERS] and Severe Acute Respiratory Syndrome [SARS]) is more likely to target the heart. Comparing the previous presentations of the coronavirus family and the recent cardiovascular manifestations of COVID-19 can also help in predicting possible future challenges and taking measures to tackle these issues.

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Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells

Journal of Biological Chemistry ◽

10.1074/jbc.ra118.001897 ◽

2018 ◽

Vol 293 (30) ◽

pp. 11709-11726 ◽

Cited By ~ 49

Author(s):

Hin Chu ◽

Che-Man Chan ◽

Xi Zhang ◽

Yixin Wang ◽

Shuofeng Yuan ◽

...

Keyword(s):

Middle East ◽

Middle East Respiratory Syndrome ◽

Host Cells ◽

Bat Coronavirus

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A Review of the Virology of SARS-CoV-2

Spectrum: Science and Technology ◽

10.54290/spect/2020.v7.1.0009 ◽

2020 ◽

Vol 7 (1) ◽

pp. 69-77

Author(s):

Aldonna Maria Susngi ◽

◽

Clara Ermine Sawian

Keyword(s):

Middle East ◽

Severe Acute Respiratory Syndrome ◽

Causative Agent ◽

Middle East Respiratory Syndrome ◽

The Novel ◽

Highly Pathogenic ◽

Key Features

The novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the causative agent of Coronavirus disease 2019 (COVID-19) is a β-coronavirus, which also includes the highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome Coronavirus (MERS-CoV). Emerging in December 2019 from Wuhan, China, it has spread worldwide resulting in a pandemic that has not ended till date. This review highlights some of the key features of the virology of SARS-CoV-2.

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Peptide-Protein Interaction Studies of Antimicrobial Peptides Targeting Middle East Respiratory Syndrome Coronavirus Spike Protein: An In Silico Approach

Advances in Bioinformatics ◽

10.1155/2019/6815105 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16 ◽

Cited By ~ 5

Author(s):

Sabeena Mustafa ◽

Hanan Balkhy ◽

Musa Gabere

Keyword(s):

Middle East ◽

Antimicrobial Peptides ◽

Protein Interactions ◽

In Silico ◽

Therapeutic Option ◽

Binding Mode ◽

Middle East Respiratory Syndrome ◽

Spike Protein ◽

In Silico Docking ◽

Peptide Database

There is no effective therapeutic or vaccine for Middle East Respiratory Syndrome and this study attempts to find therapy using peptide by establishing a basis for the peptide-protein interactions through in silico docking studies for the spike protein of MERS-CoV. The antimicrobial peptides (AMPs) were retrieved from the antimicrobial peptide database (APD3) and shortlisted based on certain important physicochemical properties. The binding mode of the shortlisted peptides was measured based on the number of clusters which forms in a protein-peptide docking using Piper. As a result, we identified a list of putative AMPs which binds to the spike protein of MERS-CoV, which may be crucial in providing the inhibitory action. It is observed that seven putative peptides have good binding score based on cluster size cutoff of 208. We conclude that seven peptides, namely, AP00225, AP00180, AP00549, AP00744, AP00729, AP00764, and AP00223, could possibly have binding with the active site of the MERS-CoV spike protein. These seven AMPs could serve as a therapeutic option for MERS and enhance its treatment outcome.

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