scholarly journals Functional and Structural Analysis of Influenza Virus Neuraminidase N3 Offers Further Insight into the Mechanisms of Oseltamivir Resistance

2013 ◽  
Vol 87 (18) ◽  
pp. 10016-10024 ◽  
Author(s):  
Q. Li ◽  
J. Qi ◽  
Y. Wu ◽  
H. Kiyota ◽  
K. Tanaka ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Structural Analysis ◽  
Oseltamivir Resistance ◽  
Influenza Virus Neuraminidase ◽  
Insight Into

scholarly journals Insight into the origin of SARS-CoV-2 through structural analysis of receptor recognition: a molecular simulation study

RSC Advances ◽  
2021 ◽  
Vol 11 (15) ◽  
pp. 8718-8729
Author(s):  
Jixue Sun ◽  
Meijiang Liu ◽  
Na Yang
Keyword(s):  
Molecular Dynamics ◽  
Structural Analysis ◽  
Molecular Dynamics Simulations ◽  
Molecular Simulation ◽  
Simulation Study ◽  
Receptor Recognition ◽  
Dynamics Simulations ◽  
Insight Into

The origin of SARS-CoV-2 through structural analysis of receptor recognition was investigated by molecular dynamics simulations.

scholarly journals Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Fengbin Wang ◽  
Ordy Gnewou ◽  
Charles Modlin ◽  
Leticia C. Beltran ◽  
Chunfu Xu ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Synthetic Peptide ◽  
Quaternary Structure ◽  
De Novo ◽  
Rational Approach ◽  
Lateral Interactions ◽  
Protein Assemblies ◽  
Self Assembling ◽  
Arginine Residues ◽  
Insight Into

AbstractThe exquisite structure-function correlations observed in filamentous protein assemblies provide a paradigm for the design of synthetic peptide-based nanomaterials. However, the plasticity of quaternary structure in sequence-space and the lability of helical symmetry present significant challenges to the de novo design and structural analysis of such filaments. Here, we describe a rational approach to design self-assembling peptide nanotubes based on controlling lateral interactions between protofilaments having an unusual cross-α supramolecular architecture. Near-atomic resolution cryo-EM structural analysis of seven designed nanotubes provides insight into the designability of interfaces within these synthetic peptide assemblies and identifies a non-native structural interaction based on a pair of arginine residues. This arginine clasp motif can robustly mediate cohesive interactions between protofilaments within the cross-α nanotubes. The structure of the resultant assemblies can be controlled through the sequence and length of the peptide subunits, which generates synthetic peptide filaments of similar dimensions to flagella and pili.

Temporal insight into the natural generation of a new reassortant porcine influenza virus in a swine holding

2014 ◽  
Vol 174 (1-2) ◽  
pp. 9-15 ◽  
Author(s):  
Chiara Chiapponi ◽  
Laura Baioni ◽  
Andrea Luppi ◽  
Ana Moreno ◽  
Alberto Castellan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Insight Into

Docking and 3D QSAR study of thiourea analogs as potent inhibitors of influenza virus neuraminidase

2010 ◽  
Vol 16 (12) ◽  
pp. 1809-1818 ◽  
Author(s):  
Jiaying Sun ◽  
Shaoxi Cai ◽  
Hu Mei ◽  
Jian Li ◽  
Ning Yan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
3D Qsar ◽  
Qsar Study ◽  
Influenza Virus Neuraminidase

Influenza Virus Neuraminidase Inhibitory Activity of Phlorotannins from the Edible Brown AlgaEcklonia cava

2011 ◽  
Vol 59 (12) ◽  
pp. 6467-6473 ◽  
Author(s):  
Young Bae Ryu ◽  
Hyung Jae Jeong ◽  
So Young Yoon ◽  
Ji-Young Park ◽  
Young Min Kim ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inhibitory Activity ◽  
Influenza Virus Neuraminidase

Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir

2015 ◽  
Vol 210 ◽  
pp. 126-132 ◽  
Author(s):  
S.-H. Sheldon Tai ◽  
Olga Agafitei ◽  
Zhizeng Gao ◽  
Richard Liggins ◽  
Martin Petric ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Influenza Virus ◽  
Neuraminidase Inhibitors ◽  
Influenza Virus Neuraminidase

scholarly journals Tanggap Siaga Dalam Masa Pandemi Covid-19 Desa Tempursari Kabupaten Magelang

2021 ◽  
Vol 4 (2) ◽  
pp. 135-140
Author(s):  
Paramita Nuraini ◽  
Atri Pratiwi ◽  
Kevin Gusti ◽  
Novina Silvita ◽  
Arinda Fauziah
Keyword(s):  
Influenza Virus ◽  
Direct Contact ◽  
Hand Washing ◽  
Guidance And Counseling ◽  
Infected Person ◽  
Study Program ◽  
Service Activity ◽  
Insight Into ◽  
Assistant Lecturer ◽  
Virus Influenza

Abstract:Corona virus is a type of influenza virus or a common virus that causes infection of the nose, sinuses or upper throat. The Covid-19 virus in humans is most commonly transmitted from an infected person to another in a number of ways. This virus can be transmitted easily through the air by coughing and sneezing. However, it can also be through direct contact such as shaking hands, touching objects and so on. Indonesia is one of the countries where the spread of the corona 19 virus is relatively fast. This virus also causes the death of victims, therefore education is needed related to preparedness during the Covid 19 Pandemic. This activity was held in Tempursari village, Magelang Regency for 1 month (June 2020) involving 1 assistant lecturer and 4 students of the Guidance and Counseling study program. Muhammadiyah University of Magelang as a companion for counseling and simulations related to proper hand washing and the use of proper masks. This service activity is expected for the community to have insight into the dangers of Covid 19 and have skills related to proper hand washing procedures and the use of proper masks so that they can reduce the spread of Covid 19, especially in Magelang district.Keywords: alert response; covid pandemic 19; wash hands  Abstrak:Virus Corona merupakan sejenis virus influenza atau virus umum yang menyebabkan infeksi pada hidung, sinus atau tenggorokan bagian atas.Virus Covid-19 pada manusia paling umum menular dari orang yang terinfeksi ke orang lain melalui berbagai cara. Virus ini dapat menular dengan mudah melalui udara dengan batuk dan bersin. Namun, bisa juga melalui kontak langsung seperti berjabat tangan, menyentuh benda dan lain sebagainya. Indonesia merupakan salah satu negara yang penyebaran Virus Covid-19 terhitung cepat. Virus ini juga  menyebabkan kematian terhadap korban, karena itu perlu adanya edukasi terkait tanggap siaga dalam masa Pandemi Covid 19. Kegiatan ini dilaksankan di desa Tempursari Kabupaten Magelang selama 1 bulan ( juni 2020) dengan melibatkan 1 dosen pendamping dan  4 mahasiswa program studi Bimbingan dan Konseling Universitas Muhammadiyah Magelang sebagai pendamping penyuluhan dan simulasi terkait cuci tangan yang benar dan penggunaan masker yang tepat. Kegiatan pengabdian ini diharapkan masyarakat memiliki wawasan terkait bahaya covid 19 dan memiliki ketrampilan terkait tata cara cuci tangan yang benar dan penggunaan masker yang tepat sehingga dapat menekan penyebaran Covid-19 khususnya di kabupaten Magelang.Kata kunci: cuci tangan; pandemi covid-19; tanggap siaga

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