Structural analysis of SRPN6 provides insight into its anti-Plasmodial function

2016 ◽  
Author(s):  
David Meekins
RSC Advances ◽  
2021 ◽  
Vol 11 (15) ◽  
pp. 8718-8729
Author(s):  
Jixue Sun ◽  
Meijiang Liu ◽  
Na Yang

The origin of SARS-CoV-2 through structural analysis of receptor recognition was investigated by molecular dynamics simulations.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Fengbin Wang ◽  
Ordy Gnewou ◽  
Charles Modlin ◽  
Leticia C. Beltran ◽  
Chunfu Xu ◽  
...  

AbstractThe exquisite structure-function correlations observed in filamentous protein assemblies provide a paradigm for the design of synthetic peptide-based nanomaterials. However, the plasticity of quaternary structure in sequence-space and the lability of helical symmetry present significant challenges to the de novo design and structural analysis of such filaments. Here, we describe a rational approach to design self-assembling peptide nanotubes based on controlling lateral interactions between protofilaments having an unusual cross-α supramolecular architecture. Near-atomic resolution cryo-EM structural analysis of seven designed nanotubes provides insight into the designability of interfaces within these synthetic peptide assemblies and identifies a non-native structural interaction based on a pair of arginine residues. This arginine clasp motif can robustly mediate cohesive interactions between protofilaments within the cross-α nanotubes. The structure of the resultant assemblies can be controlled through the sequence and length of the peptide subunits, which generates synthetic peptide filaments of similar dimensions to flagella and pili.


2014 ◽  
Vol 24 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Jeffrey M. Vinokur ◽  
Tyler P. Korman ◽  
Michael R. Sawaya ◽  
Michael Collazo ◽  
Duillio Cascio ◽  
...  

Maska ◽  
2020 ◽  
Vol 35 (200) ◽  
pp. 53-67
Author(s):  
Varja Hrvatin

New Wave of Playwriting is a compilation of two editions of the theatre segment Teritorij teatra (The Territory of Theatre) that were broadcast on Radio Študent. In the play of the introductory drama-radio form of the dialogue between the young female playwright and the young male director, it enters the field of exploring the contemporary playwriting of the youngest generation and its current position. For the starting point of the topical-structural analysis of concrete plays, the author takes the call for the Slavko Grum Award for Young Playwright and dedicates her attention to its recipients up to the year 2018. As a counterpoint, she presents various educational, staging or publication initiatives that open the doors for young playwrights. Through a short review of playwrights and their texts, the contribution offers an insight into the new generation of contemporary playwriting; by treating the topics, styles and forms that are popular among playwrights, the article aims to close the gap in the area of reflective analysis.


The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Kyle L. Fort ◽  
Michiel van de Waterbeemd ◽  
Dmitriy Boll ◽  
Maria Reinhardt-Szyba ◽  
Mikhail E. Belov ◽  
...  

Native mass spectrometry can provide insight into the structure of macromolecular biological systems.


2011 ◽  
Vol 89 (7) ◽  
pp. 701-712 ◽  
Author(s):  
Yu-Chou Dai ◽  
Woei-Jer Chuang ◽  
Kaw-Yan Chua ◽  
Chi-Chang Shieh ◽  
Jiu-Yao Wang

Author(s):  
Magnus Resch

This paper presents a detailed and comprehensive portrait of today's art gallery scene. It draws on the largest survey ever done on art galleries. It presents a market size overview, including revenue and profit numbers, statistics of the number of exhibitions, employees and sector focus. The paper helps to gain an insight into an industry that has - so far - been left outside of data analysis.


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