Genome Sequences of SAT 2 Foot-and-Mouth Disease Viruses from Egypt and Palestinian Autonomous Territories (Gaza Strip)

Two foot-and-mouth disease virus (FMDV) genome sequences have been determined for isolates collected from recent field outbreaks in North Africa (Egypt) and the Middle East (Palestinian Autonomous Territories). These data represent the first examples of complete genomic sequences for the FMDV SAT 2 topotype VII, which is thought to be endemic in countries immediately to the south of the Sahara desert. Further studies are now urgently required to provide insights into the epidemiological links between these outbreaks and to define the pathogenicity of this emerging lineage.

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Genome Sequences of Foot-and-Mouth Disease Virus O/ME-SA/Ind-2001e Strains Isolated in Pakistan

Microbiology Resource Announcements ◽

10.1128/mra.00165-20 ◽

2020 ◽

Vol 9 (18) ◽

Cited By ~ 1

Author(s):

Hayley M. Hicks ◽

Jemma Wadsworth ◽

Mehreen Azhar ◽

Muhammad Afzal ◽

Shumaila Manzoor ◽

...

Keyword(s):

Middle East ◽

South Asia ◽

Disease Virus ◽

Foot And Mouth Disease ◽

Disease Type ◽

Mouth Disease ◽

Genome Sequences ◽

Serotype O ◽

Mouth Disease Virus ◽

Foot And Mouth

The genome sequences of two foot-and-mouth disease type O viruses isolated from outbreaks of disease in cattle in Pakistan in 2019 are described. They were identified as belonging to serotype O, Middle East-South Asia topotype, Ind-2001 lineage, and e sublineage and represent the first identification of this lineage in Pakistan.

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Genome Sequence of Foot-and-Mouth Disease Virus Serotype O Isolated from Morocco in 2015

Genome Announcements ◽

10.1128/genomea.01746-15 ◽

2016 ◽

Vol 4 (2) ◽

Cited By ~ 3

Author(s):

K. Bachanek-Bankowska ◽

J. Wadsworth ◽

A. Gray ◽

N. Abouchoaib ◽

D. P. King ◽

...

Keyword(s):

Middle East ◽

South Asia ◽

North Africa ◽

Indian Subcontinent ◽

Foot And Mouth Disease ◽

Mouth Disease ◽

Serotype O ◽

Mouth Disease Virus ◽

Virus Serotype ◽

Foot And Mouth

The genome of a virus isolated from an outbreak of foot-and-mouth disease (FMD) in Morocco in 2015 is described here. This virus is classified as lineage Ind-2001d within serotype O, topotype ME-SA (Middle East-South Asia). This lineage is endemic on the Indian subcontinent but has caused outbreaks in the Middle East and North Africa since 2013.

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Reconstructing Geographical Movements and Host Species Transitions of Foot-and-Mouth Disease Virus Serotype SAT 2

mBio ◽

10.1128/mbio.00591-13 ◽

2013 ◽

Vol 4 (5) ◽

Cited By ~ 25

Author(s):

Matthew D. Hall ◽

Nick J. Knowles ◽

Jemma Wadsworth ◽

Andrew Rambaut ◽

Mark E. J. Woolhouse

Keyword(s):

Middle East ◽

Disease Virus ◽

North Africa ◽

Host Species ◽

Foot And Mouth Disease ◽

Mouth Disease ◽

Sub Saharan Africa ◽

Mouth Disease Virus ◽

Foot And Mouth ◽

Sub Saharan

ABSTRACT Of the three foot-and-mouth-disease virus SAT serotypes mainly confined to sub-Saharan Africa, SAT 2 is the strain most often recorded in domestic animals and has caused outbreaks in North Africa and the Middle East six times in the last 25 years, with three apparently separate events occurring in 2012. This study updates the picture of SAT 2 phylogenetics by using all available sequences for the VP1 section of the genome available at the time of writing and uses phylogeographic methods to trace the origin of all outbreaks occurring north of the Sahara since 1990 and identify patterns of spread among countries of endemicity. Transitions between different host species are also enumerated. Outbreaks in North Africa appear to have origins in countries immediately south of the Sahara, whereas those in the Middle East are more often from East Africa. The results of the analysis of spread within sub-Saharan Africa are consistent with it being driven by relatively short-distance movements of animals across national borders, and the analysis of host species transitions supports the role of the African buffalo (Syncerus caffer) as an important natural reservoir. IMPORTANCE Foot-and-mouth disease virus is a livestock pathogen of major economic importance, with seven distinct serotypes occurring globally. The SAT 2 serotype, endemic in sub-Saharan Africa, has caused a number of outbreaks in North Africa and the Middle East during the last decades, including three separate incidents in 2012. A comprehensive analysis of all available RNA sequences for SAT 2 has not been published for some years. In this work, we performed this analysis using all previously published sequences and 49 newly determined examples. We also used phylogenetic methods to infer the source country for all outbreaks occurring outside sub-Saharan Africa since 1990 and to reconstruct the spread of viral lineages between countries where it is endemic and movements between different host species.

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