scholarly journals Rabies Virus Infection of Primary Neuronal Cultures and Adult Mice: Failure To Demonstrate Evidence of Excitotoxicity

2006 ◽  
Vol 80 (20) ◽  
pp. 10270-10273 ◽  
Author(s):  
Simon C. Weli ◽  
Courtney A. Scott ◽  
Christopher A. Ward ◽  
Alan C. Jackson
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Hippocampal Neurons ◽  
Neuroprotective Effect ◽  
Neuronal Cultures ◽  
Primary Neuronal Cultures ◽  
Trypan Blue Exclusion ◽  
Beneficial Effects ◽  
Adult Mice ◽  
Rabies Virus Infection

ABSTRACT Cultures derived from the cerebral cortices and hippocampi of 17-day-old mouse fetuses infected with the CVS strain of rabies virus showed loss of trypan blue exclusion, morphological apoptotic features, and activated caspase 3 expression, indicating apoptosis. The NMDA (N-methyl-d-aspartate acid) antagonists ketamine (125 μM) and MK-801 (60 μM) were found to have no significant neuroprotective effect on CVS-infected neurons, while the caspase inhibitor Ac-Asp-Glu-Val aspartic acid aldehyde (25 μM) exerted a marked neuroprotective effect. Glutamate-stimulated increases in levels of intracellular calcium were reduced in CVS-infected hippocampal neurons. Ketamine (120 mg/kg of body weight/day intraperitoneally) given to CVS-infected adult mice produced no beneficial effects. We have found no supportive evidence that excitotoxicity plays an important role in rabies virus infection.

Rabies virus infection in a 21-year-old male presenting with ascending paralysis after a bat scratch

2020 ◽  
Vol 5 (3) ◽  
pp. 201-208
Author(s):  
Shay-Anne Daniels ◽  
Elizabeth M King ◽  
Christopher J Olivier ◽  
John PD Harding ◽  
Christine Fehlner-Gardiner ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Rabies Virus Infection

Search for antiviral drugs against rabies virus infection

1985 ◽  
Vol 3 ◽  
pp. 86
Author(s):  
F. Bussereau ◽  
M. Picard ◽  
O. Gosselin ◽  
J. Blancou ◽  
J.C. Chermann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Antiviral Drugs ◽  
Rabies Virus Infection

The role of the skin in rabies infection

1926 ◽  
Vol 22 (10) ◽  
pp. 1179-1179
Author(s):  
K. Khalyapin
Keyword(s):  
Virus Infection ◽  
Guinea Pig ◽  
Rabies Virus ◽  
Anatomical Features ◽  
Pig Skin ◽  
Highly Sensitive ◽  
Rabies Virus Infection

The author verified by experiment that the guinea pig skin is an organ highly sensitive to the rabies virus - infection with rabies through the skin is very easy, which the author puts in connection with its anatomical features (a rich network of nerves).

Efficacy of heteropolyanions against rabies virus infection in mice

1986 ◽  
Vol 137 ◽  
pp. 391-400 ◽  
Author(s):  
F. Bussereau ◽  
M. Picard ◽  
C. Malick ◽  
A. Tézé ◽  
J. Blancou
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Rabies Virus Infection

scholarly journals Chronic Rabies Virus Infection of Cell Cultures

1972 ◽  
Vol 6 (6) ◽  
pp. 988-995 ◽  
Author(s):  
T. J. Wiktor ◽  
H F. Clark
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Cell Cultures ◽  
Rabies Virus Infection

scholarly journals INFLUENCE OF AGE FACTORS ON IMMUNIZABILITY OF MICE TO RABIES VIRUS

1940 ◽  
Vol 72 (4) ◽  
pp. 453-461 ◽  
Author(s):  
J. Casals
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Neutralizing Antibodies ◽  
Age Factors ◽  
Swiss Mice ◽  
Virulent Virus ◽  
Rabies Virus Infection

1. W-Swiss mice 60 or more days old are more readily immunizable against rabies virus infection than 20 day old or younger mice; this difference in immunizability with increasing age is most conspicuous when vaccination with virulent virus is followed by intracerebral test infection and least apparent when vaccination with avirulent virus is followed by intramuscular test infection. 2. The titre of circulating neutralizing antibodies does not parallel the titre of immunity.

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