Reduced Apoptosis in Human Intestinal Cells Cured of Persistent Poliovirus Infection
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Type 3
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ABSTRACT Cells cured of persistent virus infection can be used to investigate cellular pathways of resistance to viral cytopathic effects. Persistent poliovirus (PV) infections were established in human intestinal Caco-2 cells, and spontaneously cured cell cultures were obtained. Two cell clones, cl6 and b13, cured of type 3 PV mutant infection and their parental Caco-2 cells were compared for susceptibility to PV infection, PV receptor CD155 expression, capacity to differentiate into polarized enterocytes, and PV-, staurosporine-, and actinomycin D-induced apoptosis. Our results strongly suggest that cells that are partially resistant to apoptosis can be selected during persistent virus infection.
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1969 ◽
Vol 5
(4)
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pp. 463-471
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2009 ◽
Vol 182
(8)
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pp. 4512-4515
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2019 ◽
Vol 109
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pp. 13-23
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1995 ◽
Vol 213
(1)
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pp. 161-168
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