scholarly journals Parainfluenza Virus 5 Expressing the G Protein of Rabies Virus Protects Mice after Rabies Virus Infection

2014 ◽  
Vol 89 (6) ◽  
pp. 3427-3429 ◽  
Author(s):  
Ying Huang ◽  
Zhenhai Chen ◽  
Junhua Huang ◽  
ZhenFang Fu ◽  
Biao He
Keyword(s):  
Public Health ◽  
Virus Infection ◽  
Rabies Virus ◽  
Parainfluenza Virus ◽  
Glycoprotein G ◽  
The World ◽  
Public Health Threat ◽  
Prevention And Treatment ◽  
Rabies Virus Infection ◽  
Parainfluenza Virus 5

Rabies remains a major public health threat around the world. Once symptoms appear, there is no effective treatment to prevent death. In this work, we tested a recombinant parainfluenza virus 5 (PIV5) strain expressing the glycoprotein (G) of rabies (PIV5-G) as a therapy for rabies virus infection: we have found that PIV5-G protected mice as late as 6 days after rabies virus infection. PIV5-G is a promising vaccine for prevention and treatment of rabies virus infection.

scholarly journals Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion

2015 ◽  
Vol 90 (1) ◽  
pp. 232-244 ◽  
Author(s):  
Dayong Tian ◽  
Zhaochen Luo ◽  
Ming Zhou ◽  
Mingming Li ◽  
Lan Yu ◽  
...  
Keyword(s):  
Public Health ◽  
Gene Product ◽  
Rabies Virus ◽  
Immune Evasion ◽  
Parent Virus ◽  
L Protein ◽  
The World ◽  
Public Health Threat

ABSTRACT Rabies, one of the oldest infectious diseases, still presents a public health threat in most parts of the world today. Its pathogen, rabies virus (RABV), can utilize its viral proteins, such as the nucleoprotein and phosphorylation protein, to subvert the host innate immune system. For a long time, the large (L) protein was believed to be essential for RABV transcription and replication, but its role in viral pathogenicity and immune evasion was not known. Recent studies have found that the conserved K-D-K-E tetrad motif in the L protein is related to the methyltransferase (MTase) activity in the viral mRNA process. In the present study, a series of RABV mutations in this motif was constructed with the recombinant CVS-B2c (rB2c) virus. Two of these mutants, rB2c-K1685A and rB2c-K1829A, were found to be stable and displayed an attenuated phenotype in both in vitro growth and in vivo pathogenicity in adult and suckling mice. Further studies demonstrated that these two mutants were more sensitive to the expression of the interferon-stimulated gene product IFIT2 than the parent virus. Taken together, our results suggest that K1685 and K1829 in the L protein play important roles in pathogenicity and immune evasion during RABV infection. IMPORTANCE Rabies continues to present a public health threat in most areas of the world, especially in the developing countries of Asia and Africa. The pathogenic mechanisms for rabies are not well understood. In the present study, it was found that the recombinant rabies viruses rB2c-K1685A and rB2c-K1829A, carrying mutations at the predicted MTase catalytic sites in the L protein, were highly attenuated both in vitro and in vivo . Further studies showed that these mutants were more sensitive to the expression of the interferon-stimulated gene product IFIT2 than the parent virus. These findings improve our understanding of rabies pathogenesis, which may help in developing potential therapeutics and an avirulent rabies vaccine.

Rabies virus infection in a 21-year-old male presenting with ascending paralysis after a bat scratch

2020 ◽  
Vol 5 (3) ◽  
pp. 201-208
Author(s):  
Shay-Anne Daniels ◽  
Elizabeth M King ◽  
Christopher J Olivier ◽  
John PD Harding ◽  
Christine Fehlner-Gardiner ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Rabies Virus Infection

Search for antiviral drugs against rabies virus infection

1985 ◽  
Vol 3 ◽  
pp. 86
Author(s):  
F. Bussereau ◽  
M. Picard ◽  
O. Gosselin ◽  
J. Blancou ◽  
J.C. Chermann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Antiviral Drugs ◽  
Rabies Virus Infection

The role of the skin in rabies infection

1926 ◽  
Vol 22 (10) ◽  
pp. 1179-1179
Author(s):  
K. Khalyapin
Keyword(s):  
Virus Infection ◽  
Guinea Pig ◽  
Rabies Virus ◽  
Anatomical Features ◽  
Pig Skin ◽  
Highly Sensitive ◽  
Rabies Virus Infection

The author verified by experiment that the guinea pig skin is an organ highly sensitive to the rabies virus - infection with rabies through the skin is very easy, which the author puts in connection with its anatomical features (a rich network of nerves).

Efficacy of heteropolyanions against rabies virus infection in mice

1986 ◽  
Vol 137 ◽  
pp. 391-400 ◽  
Author(s):  
F. Bussereau ◽  
M. Picard ◽  
C. Malick ◽  
A. Tézé ◽  
J. Blancou
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Rabies Virus Infection

scholarly journals Chronic Rabies Virus Infection of Cell Cultures

1972 ◽  
Vol 6 (6) ◽  
pp. 988-995 ◽  
Author(s):  
T. J. Wiktor ◽  
H F. Clark
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Cell Cultures ◽  
Rabies Virus Infection
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