Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes
2005 ◽
Vol 79
(9)
◽
pp. 5870-5874
◽
Keyword(s):
ABSTRACT APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with HIV-1 nucleoprotein complexes (NPC). A target sequence located within the 5′-untranslated region of the HIV-1 RNA was identified to be necessary and sufficient for efficient APO3G packaging. Fine mapping revealed a sequence normally involved in viral genomic RNA dimerization and Gag binding to be important for APO3G packaging and association with viral NPC. Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA.
2004 ◽
Vol 78
(5)
◽
pp. 2601-2605
◽
2002 ◽
Vol 76
(3)
◽
pp. 959-967
◽
2003 ◽
Vol 77
(15)
◽
pp. 8237-8248
◽
Functional Analysis of the Human Immunodeficiency Virus Type 1 Rev Protein Oligomerization Interface
1998 ◽
Vol 72
(4)
◽
pp. 2935-2944
◽
2000 ◽
Vol 74
(10)
◽
pp. 4621-4633
◽
2006 ◽
Vol 80
(2)
◽
pp. 571-577
◽