scholarly journals Pdx-1 Activates Islet  - and  -Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2

2013 ◽  
Vol 33 (20) ◽  
pp. 4017-4029 ◽  
Author(s):  
H. L. Hayes ◽  
L. G. Moss ◽  
J. C. Schisler ◽  
J. M. Haldeman ◽  
Z. Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channels ◽  
Extracellular Signal ◽  
Transient Receptor

scholarly journals TRPC expression in mesenchymal stem cells

2010 ◽  
Vol 15 (4) ◽  
Author(s):  
Frederic Torossian ◽  
Aurelie Bisson ◽  
Jean-Pierre Vannier ◽  
Olivier Boyer ◽  
Marek Lamacz
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Cell Biology ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Trpc Channels ◽  
Stem Cell Proliferation ◽  
Regulatory Processes ◽  
Transient Receptor

AbstractTransient receptor potential canonical (TRPC) channels are key players in calcium homeostasis and various regulatory processes in cell biology. Little is currently known about the TRPC subfamily members in mesenchymal stem cells (MSC), where they could play a role in cell proliferation. We report on the presence of TRPC1, 2, 4 and 6 mRNAs in MSC. Western blot and immunofluorescence staining indicate a membrane and intracellular distribution of TRPC1. Furthermore, the decrease in the level of TRPC1 protein caused by RNA interference is accompanied by the downregulation of cell proliferation. These results indicate that MSC express TRPC1, 2, 4 and 6 mRNA and that TRPC1 may play a role in stem cell proliferation.

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