Human beta interferon gene localization and expression in somatic cell hybrids

1982 ◽  
Vol 2 (5) ◽  
pp. 564-570
Author(s):  
P M Pitha ◽  
D L Slate ◽  
N B Raj ◽  
F H Ruddle
Keyword(s):  
Human Chromosome ◽  
Somatic Cell ◽  
Cdna Clone ◽  
Sequence Homology ◽  
Chromosome 9 ◽  
Gene Localization ◽  
Human Chromosomes ◽  
Somatic Cell Hybrids ◽  
Cell Hybrids ◽  
Interferon Gene

The human fibroblast interferon gene beta 1 was mapped to human chromosome 9. Sequence homology with a beta 1 cDNA clone was detected in both genomic DNA and induced mRNA of human/mouse or human/hamster somatic cell hybrids containing human chromosome 9, but not in lines lacking this chromosome or those retaining a complex translocation involving chromosomes 9 and 11. Interferon mRNA that did not share sequence homology with the beta 1 cDNA clone was detected in lines containing human chromosomes 2 and 5 but lacking chromosome 9, suggesting the presence of other unlinked interferon sequences in the human genome.

scholarly journals Human beta interferon gene localization and expression in somatic cell hybrids.

1982 ◽  
Vol 2 (5) ◽  
pp. 564-570 ◽  
Author(s):  
P M Pitha ◽  
D L Slate ◽  
N B Raj ◽  
F H Ruddle
Keyword(s):  
Human Chromosome ◽  
Somatic Cell ◽  
Cdna Clone ◽  
Sequence Homology ◽  
Chromosome 9 ◽  
Gene Localization ◽  
Human Chromosomes ◽  
Somatic Cell Hybrids ◽  
Cell Hybrids ◽  
Interferon Gene

The human fibroblast interferon gene beta 1 was mapped to human chromosome 9. Sequence homology with a beta 1 cDNA clone was detected in both genomic DNA and induced mRNA of human/mouse or human/hamster somatic cell hybrids containing human chromosome 9, but not in lines lacking this chromosome or those retaining a complex translocation involving chromosomes 9 and 11. Interferon mRNA that did not share sequence homology with the beta 1 cDNA clone was detected in lines containing human chromosomes 2 and 5 but lacking chromosome 9, suggesting the presence of other unlinked interferon sequences in the human genome.

scholarly journals Chromosomal location of a human alpha interferon gene family.

1982 ◽  
Vol 155 (4) ◽  
pp. 1019-1024 ◽  
Author(s):  
D L Slate ◽  
P D'Eustachio ◽  
D Pravtcheva ◽  
A C Cunningham ◽  
S Nagata ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Gene Family ◽  
Somatic Cell ◽  
Dna Sequences ◽  
Chromosomal Location ◽  
Dna Probe ◽  
Chromosome 9 ◽  
Alpha Interferon ◽  
Somatic Cell Hybrids ◽  
Interferon Gene

To determine the chromosomal location of the human alpha interferon genes, we scored a series of human/rodent somatic cell hybrids for the presence of DNA sequences hybridizing to an alpha 1 interferon DNA probe. The presence of human chromosome 9 in a hybrid correlated with the presence of a family of alpha interferon genes.

Analysis of tumor suppressor gene on human chromosome 9 in mouse x human somatic cell hybrids

1994 ◽  
Vol 20 (5) ◽  
pp. 391-400 ◽  
Author(s):  
Bruce W. Porterfield ◽  
Olufunmilayo I. Olopade ◽  
Janet D. Rowley ◽  
Manuel O. Diaz
Keyword(s):  
Tumor Suppressor ◽  
Human Chromosome ◽  
Somatic Cell ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Chromosome 9 ◽  
Somatic Cell Hybrids ◽  
Human Somatic Cell ◽  
Cell Hybrids

Human chromosome 16 physical map: Mapping of somatic cell hybrids using multiplex PCR deletion analysis of sequence tagged sites

Genomics ◽  
1991 ◽  
Vol 10 (4) ◽  
pp. 1047-1052 ◽  
Author(s):  
Robert I. Richards ◽  
Katherine Holman ◽  
Sharon Lane ◽  
Grant R. Sutherland ◽  
David F. Callen
Keyword(s):  
Human Chromosome ◽  
Somatic Cell ◽  
Multiplex Pcr ◽  
Physical Map ◽  
Deletion Analysis ◽  
Somatic Cell Hybrids ◽  
Chromosome 16 ◽  
Cell Hybrids ◽  
Sequence Tagged Sites

Localization of genes on human chromosomes by studies of human-Chinese hamster somatic cell hybrids

1973 ◽  
Vol 20 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Ans Jongsma ◽  
Harry Someren ◽  
Andries Westerveld ◽  
Ann Hagemeijer ◽  
Peter Pearson
Keyword(s):  
Somatic Cell ◽  
Chinese Hamster ◽  
Human Chromosomes ◽  
Somatic Cell Hybrids ◽  
Cell Hybrids

Assignment of inosine triphosphatasegene to gorilla chromosome 13 and to human chromosome 20 in primate-rodent somatic cell hybrids

1976 ◽  
Vol 16 (1-5) ◽  
pp. 420-421 ◽  
Author(s):  
Meera Khan ◽  
P.L. Pearson ◽  
L.L.L. Wijnen ◽  
B.A. Doppert ◽  
A. Westerveld ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Somatic Cell ◽  
Somatic Cell Hybrids ◽  
Chromosome 13 ◽  
Cell Hybrids ◽  
Chromosome 20 ◽  
I Gene ◽  
Inosine Triphosphatase

Mouse-Human Somatic Cell Hybrids: Loss of Mouse and Human Chromosomes

1998 ◽  
Vol 24 (3) ◽  
pp. 165-171 ◽  
Author(s):  
Xianghong Wang ◽  
Margaret Fox ◽  
Susan Povey ◽  
John R.W. Masters
Keyword(s):  
Somatic Cell ◽  
Human Chromosomes ◽  
Somatic Cell Hybrids ◽  
Human Somatic Cell ◽  
Cell Hybrids
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