Overproduction of protein p53 contributes to simian virus 40-mediated transformation
1986 ◽
Vol 6
(10)
◽
pp. 3531-3536
Keyword(s):
The possible involvement of p53 overproduction in simian virus 40 (SV40)mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced two- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.
1986 ◽
Vol 6
(10)
◽
pp. 3531-3536
◽
Keyword(s):
2002 ◽
Vol 76
(7)
◽
pp. 3145-3157
◽
Keyword(s):
Keyword(s):
Less than 40% of the simian virus 40 large T-antigen-coding sequence is required for transformation.
1984 ◽
Vol 4
(8)
◽
pp. 1661-1663
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Keyword(s):
1990 ◽
Vol 64
(2)
◽
pp. 672-679
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Keyword(s):
Keyword(s):
1991 ◽
Vol 11
(8)
◽
pp. 4253-4265
Keyword(s):
1985 ◽
Vol 5
(5)
◽
pp. 1043-1050
◽
Keyword(s):
Keyword(s):