Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors
1986 ◽
Vol 6
(11)
◽
pp. 4104-4108
Keyword(s):
Nih 3T3
◽
Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.
2000 ◽
Vol 275
(9)
◽
pp. 6560-6565
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Isolation of recessive (mediator-) revertants from NIH 3T3 cells transformed with a c-H-ras oncogene
1990 ◽
Vol 10
(4)
◽
pp. 1822-1827
Keyword(s):
Nih 3T3
◽