Effects of “Pheromone-Like” pyrazine-containing compounds on stability of genetic apparatus in bone marrow cells of the male house mouse Mus musculus L.

2009 ◽  
Vol 45 (5) ◽  
pp. 589-595 ◽  
Author(s):  
E. V. Daev ◽  
V. E. Kazarova ◽  
A. M. Vyborova ◽  
A. V. Dukel’skaya
CYTOLOGIA ◽  
2005 ◽  
Vol 70 (4) ◽  
pp. 381-384 ◽  
Author(s):  
Om Prakash Chaurasia ◽  
Alok Kumar ◽  
Moushmi Kumari

1985 ◽  
Vol 27 (3) ◽  
pp. 351-356 ◽  
Author(s):  
B. N. Nayak ◽  
M. L. Petras

Sister chromatid exchange (SCE) values were determined in bone marrow cells isolated from mouse (Mus musculus) femurs after injections of 5-bromo-2′-deoxyuridine (BrdU) and 5-fluorodeoxyuridine (FrdU). Male mice of C3H/J, C57BL/6J, and DBA/2 strains maintained in the laboratory gave mean SCE values of 3.42 ± 0.07, 3.62 ± 0.08, and 3.97 ± 0.13, respectively. Males obtained from natural populations of southwestern Ontario had a higher mean SCE value (6.02 ± 0.16), as did inbred males maintained in outdoor enclosures for at least 3 weeks (5.07 ± 0.22). Wild mice housed in the laboratory for 9 months or longer had SCE values similar to laboratory bred mice (3.46 ± 0.05). The SCE values in wild-caught mice were inversely proportional (r = −0.49) to the distance between the sites where these animals were collected and the nearest major industrial center. Based on these results, SCE analysis in mice is proposed as a possible first-line monitoring procedure for the detection of general changes in environmental genotoxicity.Key words: environmental genotoxicity, sister chromatid exchange, bone marrow cells, BrdU, FrdU, mouse.


2018 ◽  
Vol 6 (2) ◽  
pp. 169-173
Author(s):  
Manisha Kumari ◽  
Rohit Kumar Verma ◽  
Prabhat Kumar Roy

The Genotoxic effect of the carbafuran pesticide was evaluated in the metaphasic chromosomes of bone marrow cells of female Swiss albino mice, Mus musculus . Six week old mice were put into different groups(six mice per group) and treatment were done according to experimental plan (CLD15 i.e. lower dose =30ppm or 0.03mg/ml and CHD30 i.e. higher dose =300ppm or 0.3mg/ml).The test material was administered orally for 15 days in CLD15 and for 30 days in CHD30 test groups of female mice. The result revealed that the frequency of chromosomal abnormalities i.e. structural and numerical changes were11.5% in control, 74.0%in CLD15 and 99.0%in CHD30, respectively in bone marrow cells of female mice.Int. J. Appl. Sci. Biotechnol. Vol 6(2): 169-173 


2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
C Stamm ◽  
YH Choi ◽  
A Liebold ◽  
HD Kleine ◽  
S Dunkelmann ◽  
...  

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