Sympatric speciation of the plague microbe Yersinia pestis: Monohostal specialization in the host–parasite marmot–flea (Marmota sibirica–Oropsylla silantiewi) system

2016 ◽  
Vol 43 (2) ◽  
pp. 87-96 ◽  
Author(s):  
V. V. Suntsov
Keyword(s):  
Yersinia Pestis ◽  
Sympatric Speciation ◽  
Host Parasite ◽  
Marmota Sibirica

scholarly journals Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones

2018 ◽  
pp. 37-44 ◽  
Author(s):  
V. V. Suntsov
Keyword(s):  
Yersinia Pestis ◽  
Population Genetic ◽  
Molecular Genetic ◽  
Transmission Mechanism ◽  
Ecological Approach ◽  
Synthetic Theory ◽  
Genetic Approach ◽  
Theory Of Evolution ◽  
Host Parasite ◽  
Marmota Sibirica

Two approaches to studying the origin and transmission mechanism of the flea-borne plague pathogen, Yersinia pestis: molecular-genetic and ecological ones – are considered in this review. The molecular genetic approach is based on saltation evolutionary ideology and relies upon the phenomenon of horizontal gene transfer of pla and ymt as critical evolutionary events. Further deletion of some structural and regulatory genes optimized “blockage” mechanism of transmission. The Ecological approach is based on the modern synthetic theory of evolution. It posits a gradual population-genetic transformation in the Marmot – Flea (Marmota sibirica – Oropsylla silantiewi) transitional (heterothermal, heteroimmune) host-parasite system in Late Pleistocene – Holocene epochs. The best prospects for disclosing the mechanisms of evolutionary formation of flea-borne Y. pestis transmission consist in the synthesis of molecular-genetic and ecological approaches.

scholarly journals Yersinia pestis--etiologic agent of plague.

1997 ◽  
Vol 10 (1) ◽  
pp. 35-66 ◽  
Author(s):  
R D Perry ◽  
J D Fetherston
Keyword(s):  
Yersinia Pestis ◽  
Etiologic Agent ◽  
Clinical Aspects ◽  
Virulence Determinants ◽  
Health Issues ◽  
Regulatory Systems ◽  
Wide Range ◽  
Parasite Relationship ◽  
Obligate Pathogen ◽  
Host Parasite

Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history. Disappearance of the disease is unlikely due to the wide range of mammalian hosts and their attendant fleas. The flea/rodent life cycle of Y. pestis, a gram-negative obligate pathogen, exposes it to very different environmental conditions and has resulted in some novel traits facilitating transmission and infection. Studies characterizing virulence determinants of Y. pestis have identified novel mechanisms for overcoming host defenses. Regulatory systems controlling the expression of some of these virulence factors have proven quite complex. These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague.

The Pathogenesis of Experimental Mycotic Encephalitis

1969 ◽  
Vol 27 ◽  
pp. 356-357
Author(s):  
James A. Swenberg ◽  
Adalbert Koestner ◽  
R.P. Tewari
Keyword(s):  
Electron Microscopy ◽  
Pathogenetic Mechanisms ◽  
Host Parasite

Previous investigations of pathogenetic mechanisms in mycotic encephalitis have been restricted to light microscopic and mycologic approaches. In this study, electron microscopy was utilized to determine the mode of vascular penetration and the cellular and subcellular host-parasite interrelationships in brains of mice infected with Oidiodendron kalrai. This newly isolated fungus was selected because of its ability to consistently produce encephalitis with gross and microscopic lesions similar to those observed in naturally occuring mycoses.

Examination of Schistosome Cercariae and Schistosomules by Scanning Electron Microscopy

1969 ◽  
Vol 27 ◽  
pp. 50-51
Author(s):  
D. Johnson ◽  
P. Moriearty
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
High Resolution ◽  
Light Microscopy ◽  
Surface Structure ◽  
Extensive Study ◽  
Scanning Microscopy ◽  
Host Parasite ◽  
Conventional Electron Microscopy ◽  
Scanning Electron

Since several species of Schistosoma, or blood fluke, parasitize man, these trematodes have been subjected to extensive study. Light microscopy and conventional electron microscopy have yielded much information about the morphology of the various stages; however, scanning electron microscopy has been little utilized for this purpose. As the figures demonstrate, scanning microscopy is particularly helpful in studying at high resolution characteristics of surface structure, which are important in determining host-parasite relationships.

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