scholarly journals Genesis of Flea-Born Transmission of Plague Microbe, Yersinia pestis: Two Approachs – Molecular-Genetic and Ecological Ones

2018 ◽  
pp. 37-44 ◽  
Author(s):  
V. V. Suntsov
Keyword(s):  
Yersinia Pestis ◽  
Population Genetic ◽  
Molecular Genetic ◽  
Transmission Mechanism ◽  
Ecological Approach ◽  
Synthetic Theory ◽  
Genetic Approach ◽  
Theory Of Evolution ◽  
Host Parasite ◽  
Marmota Sibirica

Two approaches to studying the origin and transmission mechanism of the flea-borne plague pathogen, Yersinia pestis: molecular-genetic and ecological ones – are considered in this review. The molecular genetic approach is based on saltation evolutionary ideology and relies upon the phenomenon of horizontal gene transfer of pla and ymt as critical evolutionary events. Further deletion of some structural and regulatory genes optimized “blockage” mechanism of transmission. The Ecological approach is based on the modern synthetic theory of evolution. It posits a gradual population-genetic transformation in the Marmot – Flea (Marmota sibirica – Oropsylla silantiewi) transitional (heterothermal, heteroimmune) host-parasite system in Late Pleistocene – Holocene epochs. The best prospects for disclosing the mechanisms of evolutionary formation of flea-borne Y. pestis transmission consist in the synthesis of molecular-genetic and ecological approaches.

Evolution, genetics, and systematics

2017 ◽  
Author(s):  
Francisco J. Ayala ◽  
Camilo J. Cela-Conde
Keyword(s):  
Population Genetics ◽  
Sexual Selection ◽  
Fossil Record ◽  
Life Sciences ◽  
Altruistic Behavior ◽  
Synthetic Theory ◽  
Theory Of Evolution ◽  
Evolution By Natural Selection ◽  
Current Paradigm ◽  
Epigenetic Processes

This chapter starts with the general principles of the theory of evolution by natural selection advanced by Darwin and the Mendelian theory of heredity. Next comes consideration of the “new-Darwinian synthesis” or “synthetic theory,” which integrates both precedents into what has become the current paradigm of the life sciences. Molecular evolution and population genetics follow, including epigenetic processes. Next, special models of selection are considered, such as sexual selection and the models that account for altruistic behavior. After the mechanisms of speciation, the main concepts of systematics are explored, which facilitate understanding of different traits. The chapter finally explores the fundamental concepts of taxonomy and the methods from phenetics to cladistics, that makes it possible to evaluate the diversity of organisms and the methods for dating the fossil record.

The population genetic approach delineates the species boundary of reproductively isolated corymbose acroporid corals

2012 ◽  
Vol 63 (2) ◽  
pp. 527-531 ◽  
Author(s):  
Yuichi Nakajima ◽  
Akira Nishikawa ◽  
Akira Iguchi ◽  
Kazuhiko Sakai
Keyword(s):  
Population Genetic ◽  
Genetic Approach ◽  
Species Boundary

scholarly journals The factors and conditions of evolution – past and present

1970 ◽  
pp. 373-377
Author(s):  
R. P. Piskun ◽  
V. M. Shkarupa ◽  
I. M. Molchan ◽  
K. V. Musatova ◽  
N. M. Hrynchak
Keyword(s):  
Genetic Code ◽  
Scientific Literature ◽  
Active Participation ◽  
Scientific Data ◽  
Synthetic Theory ◽  
Active System ◽  
Continuous Development ◽  
Theory Of Evolution ◽  
Self Organized ◽  
The Right

Aim. As the genetic code is actually a protein’s code so still leaves in the shade the answer to the question that is our aim. Why in the certain time, in the right place happens the proper phenomenon during the formation of various configurations of cells, organs and organisms. Methods. Studying and analyzing the various scientific literature, we sought to theoretically give an answer to this question. Results. Synthetic theory of evolution is considering genome as a passive structure that encodes and transmits accidentally arising variations of genotypes. However, in recent years become more known the facts that indicate the genome is an active system that self-regulated and self-organized. The genome includes not only the material for evolution, but the mechanisms of its application for the creation of new genotypes and phenotypes in the future for active participation in the process of their own evolution. The modern scientific data confirm that most evolutionarily success is the genome that is capable of change. This means that in the genome there are mechanisms that control and create diverse and concerted restructuring of DNA. Conclusions. Evolution is the continuous development in which organisms survive. The evolution is typical for all levels of nature. The main active factors of evolution are a mutation, a recombination, a hybridization and a transgenesis. Keywords: evolution, genes, factors, history.

scholarly journals Comparative Genetic Analysis of Yersinia pestis Strains Isolated on the Ukok Plateau and other Territories of the Altai Mountains

2021 ◽  
pp. 59-69
Author(s):  
G. A. Eroshenko ◽  
A. N. Balykova ◽  
Ya. M. Krasnov ◽  
E. A. Naryshkina ◽  
E. N. Rozhdestvensky ◽  
...  
Keyword(s):  
Yersinia Pestis ◽  
De Novo ◽  
Molecular Genetic ◽  
Genetic Identification ◽  
Likelihood Method ◽  
High Mountain ◽  
Altai Mountains ◽  
Natural Foci ◽  
Ukok Plateau ◽  
Average Size

The aim of the study was molecular-genetic identification and analysis of the phylogenetic relationship of Yersinia pestis strains isolated on the Ukok Plateau in 2020, in order to establish the current boundaries of the natural mega focus of plague in the Altai Mountains in Russia and Mongolia.Materials and methods. 37 strains of Y. pestis of the main subspecies isolated in the Tuva mountain and Gorno-Altai high-mountain plague foci and adjacent territories of Mongolia in 1971–2020 were studied. The whole genome sequencing of the strains was performed using the Ion S5 XL System (Thermo Fischer Scientific). Ion Torrent Suite software package 5.12 and Newbler gsAssembler 2.6 were used to process the data and assemble de novo the sequences of raw reads. The average size of the collected genome was 4.55 million base pairs. Core SNPs were detected by aligning the contigs of Y. pestis strains on the CO92 genome using the Snippy 4.6 program, then 28 SNP homoplasies were removed. The resulting set of SNPs contained only the core region of the genome (955 SNPs). The dendrogram was constructed using the Maximum Likelihood method applying the PhyML 3.1 program.Results and discussion. The current population structure of Y. pestis of the main subspecies, antique biovar, phylogenetic line 4.ANT, endemic to the foci of the Altai Mountains in Russia and Mongolia has been determined. The presence of 4.ANT-21 clone, which became widespread in the territory of these natural foci of plague at the begining of the XXI century, was revealed. It is shown that three strains isolated on the Ukok Plateau in 2020 belong to clone 4.ANT-21. According to phylogenetic analysis, evidence of 4.ANT circulation on the Ukok Plateau before 2018 was obtained. The lesson that has been learned is that it is necessary to study the territories of Mongolia, Kazakhstan and China bordering the Ukok Plateau in order to establish the current boundaries of the 4.ANT mega focus. 

A Combined NMR and Molecular Genetic Approach to Studying Enzymes in Vivo

1994 ◽  
pp. 237-262 ◽  
Author(s):  
Kevin M. Brindle ◽  
Alexandra M. Fulton ◽  
Simon-Peter Williams
Keyword(s):  
Molecular Genetic ◽  
Genetic Approach
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