Non-Phosphorus Lipids As New Antitumor Drug Prototypes

Chitin (poly-N-acetyl-D-glucosamine) is the second (after cellulose) most abundant organic polymer. In its deacetylated form—chitosan—becomes a very interesting material for medical use. The chitosan nano-structures whose preparation is described in this article shows unique biomedical value. The preparation of nanochitosan, as well as the most vital biomedical applications (antitumor, drug delivery and other medical uses), have been discussed in this review. The challenges confronting the progress of nanochitosan from benchtop to bedside clinical settings have been evaluated. The need for inclusion of nano aspects into chitosan research, with improvisation from nanotechnological inputs has been prescribed for breaking down the limitations. Future perspectives of nanochitosan and the challenges facing nanochitosan applications and the areas needing research focus have been highlighted.

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Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065

Biochemistry ◽

10.1021/bi00368a014 ◽

1986 ◽

Vol 25 (20) ◽

pp. 5929-5932 ◽

Cited By ~ 12

Author(s):

Myron K. Jacobson ◽

Debra Twehous ◽

Laurence H. Hurley

Keyword(s):

Nicotinamide Adenine Dinucleotide ◽

Xeroderma Pigmentosum ◽

Antitumor Drug ◽

Nicotinamide Adenine ◽

Fibroblast Cells

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Fractionation and Characterization of a Conjugate between a Polymeric Drug-Carrier and the Antitumor Drug Camptothecin

Bioconjugate Chemistry ◽

10.1021/bc025522d ◽

2002 ◽

Vol 13 (6) ◽

pp. 1253-1258 ◽

Cited By ~ 22

Author(s):

R. Mendichi ◽

V. Rizzo ◽

M. Gigli ◽

A. Giacometti Schieroni

Keyword(s):

Drug Carrier ◽

Antitumor Drug ◽

Polymeric Drug Carrier ◽

Polymeric Drug

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Polymeric topology and composition constrained polyether–polyester micelles for directional antitumor drug delivery

Acta Biomaterialia ◽

10.1016/j.actbio.2013.06.041 ◽

2013 ◽

Vol 9 (11) ◽

pp. 8875-8884 ◽

Cited By ~ 33

Author(s):

Di Li ◽

Hai Sun ◽

Jianxun Ding ◽

Zhaohui Tang ◽

Ying Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Antitumor Drug

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Selective Accumulation of the Endoplasmic Reticulum–Golgi Intermediate Compartment Induced by the Antitumor Drug KRN5500

Experimental Cell Research ◽

10.1006/excr.2000.4851 ◽

2000 ◽

Vol 256 (2) ◽

pp. 468-479 ◽

Cited By ~ 4

Author(s):

Masaru Kamishohara ◽

Susan Kenney ◽

Renee Domergue ◽

David T. Vistica ◽

Edward A. Sausville

Keyword(s):

Endoplasmic Reticulum ◽

Antitumor Drug ◽

Intermediate Compartment ◽

Selective Accumulation

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Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

Journal of Materials Chemistry B ◽

10.1039/c5tb02083b ◽

2016 ◽

Vol 4 (6) ◽

pp. 1100-1107 ◽

Cited By ~ 12

Author(s):

Ruiqing Liu ◽

Shuang Liang ◽

Cun Jiang ◽

Li Zhang ◽

Tianmeng Yuan ◽

...

Keyword(s):

Drug Delivery ◽

Magnetic Resonance ◽

Optical Imaging ◽

Emulsion Polymerization ◽

Gadolinium Oxide ◽

Antitumor Drug ◽

Ph Responsive ◽

Polymeric Particles ◽

Polymeric Particle

Paramagnetic, luminescent, and temperature/pH-responsive polymeric particles with MR/optical imaging and antitumor drug delivery capability are prepared by emulsifier-free emulsion polymerization.

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