Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

2016 ◽  
Vol 4 (6) ◽  
pp. 1100-1107 ◽  
Author(s):  
Ruiqing Liu ◽  
Shuang Liang ◽  
Cun Jiang ◽  
Li Zhang ◽  
Tianmeng Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Emulsion Polymerization ◽  
Gadolinium Oxide ◽  
Antitumor Drug ◽  
Ph Responsive ◽  
Polymeric Particles ◽  
Polymeric Particle

Paramagnetic, luminescent, and temperature/pH-responsive polymeric particles with MR/optical imaging and antitumor drug delivery capability are prepared by emulsifier-free emulsion polymerization.

pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (Gd2O3@MSNs) for synergistic drug delivery and magnetic resonance imaging enhancement

2019 ◽  
Vol 7 (43) ◽  
pp. 6840-6854 ◽  
Author(s):  
Kewu He ◽  
Jiajia Li ◽  
Yuxian Shen ◽  
Yongqiang Yu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Gadolinium Oxide ◽  
Imaging Modalities ◽  
Ph Responsive ◽  
Resonance Imaging

Theranostic platforms that combine therapeutic and imaging modalities have received increasing interest.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Paramagnetic, pH and temperature-sensitive polymeric particles for anticancer drug delivery and brain tumor magnetic resonance imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (106) ◽  
pp. 87512-87520 ◽  
Author(s):  
Ruiqing Liu ◽  
Shuang Liang ◽  
Cun Jiang ◽  
Xin Wang ◽  
Ying Gong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Brain Tumor ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Anticancer Drug ◽  
Temperature Sensitive ◽  
Resonance Imaging ◽  
Anticancer Drug Delivery ◽  
Polymeric Particles

Dually responsive polymeric particles for brain tumor (glioma) MR imaging and anticancer drug delivery.

scholarly journals A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5274
Author(s):  
Qian He ◽  
Rui Yan ◽  
Wanting Hou ◽  
Haibo Wang ◽  
Yali Tian
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Cellular Uptake ◽  
Delivery System ◽  
Antitumor Drug ◽  
Control Group ◽  
Ph Responsive ◽  
Cytotoxicity Studies

Numerous nanocarriers with excellent biocompatibilities have been used to improve cancer therapy. However, nonspecific protein adsorption of nanocarriers may block the modified nanoparticles in tumor cells, which would lead to inefficient cellular internalization. To address this issue, pH-responsive polyurethane prodrug micelles with a zwitterionic segment were designed and prepared. The micelle consisted of a zwitterionic segment as the hydrophilic shell and the drug Adriamycin (DOX) as the hydrophobic inner core. As a pH-responsive antitumor drug delivery system, the prodrug micelles showed high stability in a physiological environment and continuously released the drug under acidic conditions. In addition, the pure polyurethane carrier was demonstrated to be virtually non-cytotoxic by cytotoxicity studies, while the prodrug micelles were more efficient in killing tumor cells compared to PEG-PLGA@DOX. Furthermore, the DOX cellular uptake efficiency of prodrug micelles was proved to be obviously higher than the control group by both flow cytometry and fluorescence microscopy. This is mainly due to the modification of a zwitterionic segment with PU. The simple design of zwitterionic prodrug micelles provides a new strategy for designing novel antitumor drug delivery systems with enhanced cellular uptake rates.

In situ growth of metal–organic frameworks (MOFs) on the surface of other MOFs: a new strategy for constructing magnetic resonance/optical dual mode imaging materials

2017 ◽  
Vol 46 (40) ◽  
pp. 13686-13689 ◽  
Author(s):  
Xuechuan Gao ◽  
Guanfeng Ji ◽  
Ruixue Cui ◽  
Jingjuan Liu ◽  
Zhiliang Liu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Metal Organic Frameworks ◽  
In Situ Growth ◽  
Dual Mode ◽  
New Strategy ◽  
Metal Organic ◽  
First Time

This work presents for the first time the synthesis of a novel nanoscale Fe-MOF/Eu-MOF heterostructure, which exhibits excellent magnetic resonance/optical imaging capacity and satisfactory drug delivery behavior.

Sign in / Sign up

Export Citation Format

Share Document