First Polynuclear Palladium Compounds [(C5H12NO)(PdCl3)]n and [(C10H16NO)2(Pd2Cl6)] with High Antitumor and Radioprotective Activity

2020 ◽  
Vol 46 (5) ◽  
pp. 339-349
Author(s):  
I. A. Efimenko ◽  
M. V. Filimonova ◽  
A. V. Churakov ◽  
N. A. Ivanova ◽  
O. S. Erofeeva ◽  
...  
Keyword(s):  
Radioprotective Activity ◽  
Palladium Compounds

scholarly journals In Vivo Radioprotective Activity of Cell-Permeable Bifunctional Antioxidant Enzyme GST-TAT-SOD against Whole-Body Ionizing Irradiation in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jianru Pan ◽  
Huocong He ◽  
Ying Su ◽  
Guangjin Zheng ◽  
Junxin Wu ◽  
...  
Keyword(s):  
Growth Rate ◽  
Antioxidant Activity ◽  
Body Weight ◽  
Whole Body ◽  
White Pulp ◽  
Radioprotective Activity ◽  
Significant Difference ◽  
Wbc Count

GST-TAT-SOD was the fusion of superoxide dismutase (SOD), cell-permeable peptide TAT, and glutathione-S-transferase (GST). It was proved to be a potential selective radioprotector in vitro in our previous work. This study evaluated the in vivo radioprotective activity of GST-TAT-SOD against whole-body irradiation. We demonstrated that intraperitoneal injection of 0.5 ml GST-TAT-SOD (2 kU/ml) 2 h before the 6 Gy whole-body irradiation in mice almost completely prevented the splenic damage. It could significantly enhance the splenic antioxidant activity which kept the number of splenic white pulp and consequently resisted the shrinkage of the spleen. Moreover, the thymus index, hepatic antioxidant activity, and white blood cell (WBC) count of peripheral blood in irradiated mice pretreated with GST-TAT-SOD also remarkably increased. Although the treated and untreated irradiated mice showed no significant difference in the growth rate of animal body weight at 7 days postirradiation, the highest growth rate of body weight was observed in the GST-TAT-SOD-pretreated group. Furthermore, GST-TAT-SOD pretreatment increased resistance against 8 Gy whole-body irradiation and enhanced 30 d survival. The overall effect of GST-TAT-SOD seemed to be a bit more powerful than that of amifostine. In conclusion, GST-TAT-SOD would be a safe and potentially promising radioprotector.

Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives

1989 ◽  
Vol 32 (2) ◽  
pp. 297-301 ◽  
Author(s):  
Joel Oiry ◽  
Jean Y. Pue ◽  
Jean L. Imbach ◽  
Marc Fatome ◽  
Henry Sentenac-Roumanou
Keyword(s):  
Radioprotective Activity

Selective Catalytic Hydrodimerization of 1,3-Butadiene by Palladium Compounds Dissolved in Ionic Liquids

1998 ◽  
Vol 17 (5) ◽  
pp. 815-819 ◽  
Author(s):  
Jeane E. L. Dullius ◽  
Paulo A. Z. Suarez ◽  
Sandra Einloft ◽  
Roberto F. de Souza ◽  
Jairton Dupont ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Palladium Compounds

Synthesis and radioprotective activity of some derivatives ofN-(3-aryladamant-1-ylmethyl)mercaptoacetamidine

1993 ◽  
Vol 27 (8) ◽  
pp. 585-588
Author(s):  
L. N. Lavrova ◽  
N. P. Savchenko ◽  
A. M. Vasil'ev ◽  
V. S. Korytnyi ◽  
V. V. Znamenskii ◽  
...  
Keyword(s):  
Radioprotective Activity

scholarly journals In vitro Radioprotective Activity of the Bryozoan Hyalinella punctata

2013 ◽  
Vol 25 (8) ◽  
pp. 4713-4714 ◽  
Author(s):  
Boris Pejin ◽  
Bojana Stanimirovic ◽  
Neda Djordjevic ◽  
Aleksandar Hegedis ◽  
Ivo Karaman ◽  
...  
Keyword(s):  
Radioprotective Activity

Radioprotective activity of curcumin-encapsulated liposomes against genotoxicity caused by Gamma Cobalt-60 irradiation in human blood cells

2017 ◽  
Vol 93 (11) ◽  
pp. 1267-1273 ◽  
Author(s):  
Minh-Hiep Nguyen ◽  
Ngoc-Duy Pham ◽  
Bingxue Dong ◽  
Thi-Huynh-Nga Nguyen ◽  
Chi-Bao Bui ◽  
...  
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Radioprotective Activity ◽  
Human Blood Cells

scholarly journals RADIOPROTECTIVE ACTIVITY OF MULTIPHYTOADAPTOGEN PREPARATION IN MICE UNDER VARIOUS CONDITIONS OF GAMMA RADIATION

2012 ◽  
Vol 10 (2) ◽  
pp. 36 ◽  
Author(s):  
O. A. Bocharova ◽  
R. V. Karpova ◽  
I. V. Kazeev ◽  
E. V. Bocharov
Keyword(s):  
Gamma Radiation ◽  
Radioprotective Activity

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