Classical Model of 6-Hydroxydopamine-Induced Parkinsonism in Rats Is Characterized by Unilateral Lesion of Brain Mesolimbic System

2020 ◽  
Vol 14 (3) ◽  
pp. 303-309
Author(s):  
A. V. Stavrovskaya ◽  
D. S. Berezhnoy ◽  
D. N. Voronkov ◽  
S. L. Stvolinskii ◽  
D. A. Abaimov ◽  
...  
Keyword(s):  
Classical Model ◽  
Unilateral Lesion ◽  
Mesolimbic System ◽  
6 Hydroxydopamine

scholarly journals Effects of bacterial lipopolysaccharide exposure on immune responsiveness in a rodent model of Parkinson’s disease

2011 ◽  
Vol 63 (1) ◽  
pp. 99-105
Author(s):  
L. Hritcu ◽  
M. Stefan ◽  
Costica Misaila ◽  
A. Ciobica ◽  
Gabriela Dumitru
Keyword(s):  
Risk Factor ◽  
T Lymphocytes ◽  
Substantia Nigra ◽  
Immune Modulation ◽  
Hemoglobin Level ◽  
Immune Responsiveness ◽  
Unilateral Lesion ◽  
Blastic Transformation ◽  
Immunological Changes ◽  
6 Hydroxydopamine

The effects of lipopolysaccharide (LPS) on immune modulation in rats subjected to a right-unilateral lesion of the substantia nigra neurons by means of 6-hydroxydopamine (6-OHDA), were investigated. LPS administration (250 ?g) significantly decreases the total number of leukocytes and erythrocytes, as well as the hemoglobin level in the 6-OHDAlesioned rats. In addition, LPS administration was also associated with an increase, relative to control, in the erythrocyte indexes and the phagocytosis by neutrophils, and in blastic transformation of T lymphocytes. The obtained data indicated that LPS exposure might represent a risk factor for the development of the immunological changes associated with Parkinson?s disease.

Corpus callosotomy for children suffering from intractable focal epilepsy presenting a non-laterialized EEG and unilateral lesion

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
T Getzinger ◽  
T Pieper ◽  
S Keßler-Uberti ◽  
B Pascher ◽  
H Eitel ◽  
...  
Keyword(s):  
Focal Epilepsy ◽  
Unilateral Lesion ◽  
Corpus Callosotomy

Effect of 6-Hydroxydopamine on Neonate Spontaneously Hypertensive and Normotensive Rats

1976 ◽  
Vol 17 (3) ◽  
pp. 419-419 ◽  
Author(s):  
Masayori OZAKI ◽  
Kazunobu SUGAWARA ◽  
Naoko TAKAMI ◽  
Masashi OGAWA ◽  
Masami NIWA
Keyword(s):  
Spontaneously Hypertensive ◽  
6 Hydroxydopamine
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