Effects of bacterial lipopolysaccharide exposure on immune responsiveness in a rodent model of Parkinson’s disease
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The effects of lipopolysaccharide (LPS) on immune modulation in rats subjected to a right-unilateral lesion of the substantia nigra neurons by means of 6-hydroxydopamine (6-OHDA), were investigated. LPS administration (250 ?g) significantly decreases the total number of leukocytes and erythrocytes, as well as the hemoglobin level in the 6-OHDAlesioned rats. In addition, LPS administration was also associated with an increase, relative to control, in the erythrocyte indexes and the phagocytosis by neutrophils, and in blastic transformation of T lymphocytes. The obtained data indicated that LPS exposure might represent a risk factor for the development of the immunological changes associated with Parkinson?s disease.
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1978 ◽
Vol 62
(1)
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pp. 173-190
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2003 ◽
Vol 351
(3)
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pp. 186-190
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2014 ◽
Vol 70
(2)
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pp. 1247-1254
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