Modeling of discrete currents of single ion channels of cell membranes using synthetic nanometer pores in polyethylene terephthalate films

2008 ◽  
Vol 2 (1) ◽  
pp. 81-86 ◽  
Author(s):  
A. A. Lev ◽  
V. A. Gotlib ◽  
N. E. Lebedeva
Keyword(s):  
Ion Channels ◽  
Polyethylene Terephthalate ◽  
Cell Membranes

scholarly journals A complicated complex: Ion channels, voltage sensing, cell membranes and peptide inhibitors

2018 ◽  
Vol 679 ◽  
pp. 35-47 ◽  
Author(s):  
Alan H. Zhang ◽  
Gagan Sharma ◽  
Eivind A.B. Undheim ◽  
Xinying Jia ◽  
Mehdi Mobli
Keyword(s):  
Ion Channels ◽  
Cell Membranes ◽  
Peptide Inhibitors ◽  
Voltage Sensing ◽  
Complex Ion

Structural and Functional Modulation of Ion Channels by Specific Lipids: from Model Systems to Cell Membranes

2006 ◽  
pp. 203-231
Author(s):  
Asia M. Fernández ◽  
José A. Poveda ◽  
José A. Encinar ◽  
Andrés Morales ◽  
José M. González-Ros
Keyword(s):  
Ion Channels ◽  
Cell Membranes ◽  
Model Systems ◽  
Specific Lipids ◽  
Functional Modulation

scholarly journals Fengycin induces ion channels in lipid bilayers mimicking target fungal cell membranes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anastasiia A. Zakharova ◽  
Svetlana S. Efimova ◽  
Valery V. Malev ◽  
Olga S. Ostroumova
Keyword(s):  
Ion Channels ◽  
Lipid Bilayers ◽  
Cell Membranes ◽  
Membrane Lipids ◽  
Electrical Potential ◽  
Membrane Conductance ◽  
Pressure Profile ◽  
Molecular Shape ◽  
Bathing Solution ◽  
Fungal Cell

Abstract The one-sided addition of fengycin (FE) to planar lipid bilayers mimicking target fungal cell membranes up to 0.1 to 0.5 μM in the membrane bathing solution leads to the formation of well-defined and well-reproducible single-ion channels of various conductances in the picosiemens range. FE channels were characterized by asymmetric conductance-voltage characteristic. Membranes treated with FE showed nonideal cationic selectivity in potassium chloride bathing solutions. The membrane conductance induced by FE increased with the second power of the lipopeptide aqueous concentration, suggesting that at least FE dimers are involved in the formation of conductive subunits. The pore formation ability of FE was not distinctly affected by the molecular shape of membrane lipids but strongly depended on the presence of negatively charged species in the bilayer. FE channels were characterized by weakly pronounced voltage gating. Small molecules known to modify the transmembrane distribution of electrical potential and the lateral pressure profile were used to modulate the channel-forming activity of FE. The observed effects of membrane modifiers were attributed to changes in lipid packing and lipopeptide oligomerization in the membrane.

scholarly journals Bioactivity of Inositol Phosphates

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 5042
Author(s):  
Ivana Vucenik
Keyword(s):  
Signal Transduction ◽  
Ion Channels ◽  
Cell Membranes ◽  
Inositol Phosphates ◽  
Structural Components ◽  
Energy Transmission ◽  
Cellular Functions

Inositol phosphates (IPs) are a huge and complex family of biomolecules, important in regulating vital cellular functions, signal transduction, energy transmission, and ion channels physiology and serving as structural components of cell membranes [...]

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