Membrane type 1 matrix metalloproteinase (MT1-MMP) and its endogenous regulators as invasive factors in squamous cell cervical carcinoma

2015 ◽  
Vol 9 (4) ◽  
pp. 351-354 ◽  
Author(s):  
O. S. Timoshenko ◽  
T. A. Gureeva ◽  
E. V. Kugaevskaya ◽  
N. I. Solovyeva
Keyword(s):  
Matrix Metalloproteinase ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Endogenous Regulators ◽  
Squamous Cell Cervical Carcinoma ◽  
Membrane Type

scholarly journals Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas

2014 ◽  
Vol 60 (6) ◽  
pp. 683-688 ◽  
Author(s):  
O.S. Timoshenko ◽  
T.A. Gureeva ◽  
E.V. Kugaevskaya ◽  
N.I. Solovyeva
Keyword(s):  
Matrix Metalloproteinase ◽  
Squamous Cell ◽  
Tumor Invasion ◽  
Tumor Tissue ◽  
Additional Contribution ◽  
Invasive Potential ◽  
Cervical Carcinomas ◽  
Endogenous Regulators ◽  
Membrane Type

Membrane type 1 matrix metalloproteinase (MT1MMP) is one of matrix metalloproteinases (MMP), which play а key role in tumor invasion and metastasis. The aim of this study was to elucidate the peculiarities of expression of MT1MMP and endogenous regulators of its activity: the activator – furin and the inhibitor – TIMP-2, as invasive factors of squamous cell cervical carcinomas (SCC). The study was carried out using 11 specimens of SCC and 11 specimens of morphologically normal tissue adjacent to the tumor. It was shown that the increase of MT1-MMP and furin expression and low of TIMP-2 expression makes the main contribution to the destructive (invasive) potential of SCC. Moreover, substantial expression of MT1-MMP was registered in the specimens of morphologically normal adjoining to tumor tissue. This expression was found to make an additional contribution to the destructive potential of the cervical tumor.

Gelatinases A and B and their endogenous regulators in the corpus uteri in squamous cell cervical carcinoma

2018 ◽  
Vol 80 (6) ◽  
pp. 22 ◽  
Author(s):  
O. S. Timoshenko ◽  
T. A. Gureeva ◽  
E. V. Kugaevskaya ◽  
L. E. Zavalishina ◽  
Yu. Yu. Andreeva ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Corpus Uteri ◽  
Endogenous Regulators ◽  
Squamous Cell Cervical Carcinoma ◽  
Gelatinases A And B

scholarly journals Expression of Membrane Type 1 Matrix Metalloproteinase Is Associated with Cervical Carcinoma Progression and Invasion

2005 ◽  
Vol 65 (15) ◽  
pp. 6543-6550 ◽  
Author(s):  
Yali Zhai ◽  
Kevin B. Hotary ◽  
Bin Nan ◽  
F. Xavier Bosch ◽  
Nubia Muñoz ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Cervical Carcinoma ◽  
Membrane Type
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