The determination of acetone using mass spectrometry after acid hydrolysis of polymer acetals

1983 ◽  
Vol 48 (7) ◽  
pp. 2015-2020 ◽  
Author(s):  
Slavko Hudeček ◽  
Jaroslava Otoupalová ◽  
Miroslav Ryska ◽  
Jan Světlík ◽  
Pavel Čefelín
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Determination ◽  
Methyl Methacrylate ◽  
Acid Hydrolysis ◽  
Internal Standard ◽  
Mass Spectrometric ◽  
Spectrometric Method ◽  
Mass Spectrometric Method ◽  
Hydrolysis Of

A mass spectrometric method for the determination of acetone in the presence of polymers has been suggested. Perdeuterated acetone was used as the internal standard. The method was employed in a quantitative determination of (2,2-dimethyl-1,3-dioxolane-4-yl) methyl methacrylate units in copolymers with methyl methacrylate and in the determination of copolymerization parameters.

Quantitative Confirmation of Dimethoate Residues in Wheat Plants by Single Ion Mass Spectrometry

1979 ◽  
Vol 62 (4) ◽  
pp. 782-785
Author(s):  
Young W Lee ◽  
Neil D Westcott
Keyword(s):  
Mass Spectrometry ◽  
Internal Standard ◽  
Wheat Plant ◽  
Mass Spectrometric ◽  
Spectrometric Method ◽  
Plant Sample ◽  
Minimum Detectable Concentration ◽  
Mass Spectrometric Method ◽  
Base Peak ◽  
Detectable Concentration

Abstract A gas chromatographic-single ion mass spectrometric method was developed for determining dimethoate residues in wheat plants. The base peak (m/e 87) of dimethoate was chosen as the single ion peak, and methyl stearate was used as an internal standard for this analysis. The minimum detectable concentration of dimethoate by this method was about 0.1 ppm for a 20 g wheat plant sample. The recoveries of dimethoate were about 89% at 0.13 ppm and >96% at 0.5-1 ppm.

scholarly journals Rapid, Sensitive and Validated Ultra-Performance Liquid Chromatography/Mass Spectrometric Method for the Determination of Fenofibric Acid and its Application to Human Pharmacokinetic Study

2010 ◽  
Vol 7 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Sunil K. Dubey ◽  
Manoj S. Tomar ◽  
Anil Kumar Patni ◽  
Arshad Khuroo ◽  
Simrit Reyar ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Internal Standard ◽  
Negative Ions ◽  
Ultra Performance Liquid Chromatography ◽  
Mass Spectrometric ◽  
Spectrometric Method ◽  
Good Precision ◽  
Mass Spectrometric Method ◽  
Fenofibric Acid

The first, rapid and sensitive ultra performance liquid chromatography mass spectrometric method for the determination of fenofibric acid, the active metabolite of fenofibrate, a lipid regulating agent, in human EDTA plasma has been developed and validated using fenofibric d6 acid as internal standard and Waters LC-MS/MS. Negative ions of fenofibric acid and fenofibric d6 acid were detected in multiple reaction-monitoring (MRM) mode. The method was validated over a concentration range of 0.176 μg/mL to 19.837 μg/mL (r ≥ 0.99). It took only 1.5 minute to analyse a sample. Intra- and inter-run precision of fenofibric acid assay at four concentrations ranged from 0.5% to 4.3% with accuracy varied from 93.1 to 108.1% indicating good precision and accuracy. Analytical recoveries of fenofibric acid and internal standard in plasma were less than 90%. This method was successfully applied for evaluation of pharmacokinetics of fenofibric acid after a single oral dose of 145 mg fenofibrate to 10 Indian healthy volunteers

scholarly journals Development and Validation of a Liquid Chromatographic/Tandem Mass Spectrometric Method for Determination of Tetracycline in Human Plasma: Application to Bioequivalence Study

2008 ◽  
Vol 91 (4) ◽  
pp. 731-738 ◽  
Author(s):  
Liberato Brum ◽  
Ana Maria Pugens ◽  
Mariely Camila Pritsch ◽  
Patricia Bertuol Mantovani ◽  
Maurício Bedim dos Santos ◽  
...  
Keyword(s):  
Human Plasma ◽  
Multiple Reaction Monitoring ◽  
Internal Standard ◽  
Mass Spectrometric ◽  
Spectrometric Method ◽  
Tandem Mass ◽  
Mass Spectrometric Method ◽  
Tandem Mass Spectrometric ◽  
Liquid Chromatographic

Abstract A fast, sensitive, and specific liquid chromatographic/tandem mass spectrometric method was developed and validated for determination of tetracycline in human plasma. Tetracycline and oxytetracycline [internal standard (IS)] were extracted from the plasma by protein precipitation. The mobile phase consisted of acetonitrileformic acid 0.1 (48 + 52, v/v), run at a flow rate of 1 mL/min (split 1:5). Detection was performed by positive electrospray ionization in multiple reaction monitoring mode, monitoring the transitions 444.8 > 410.0 and 461.0 > 426.0 for tetracycline and IS, respectively. The analysis was performed in 3.5 min and the method was linear in the plasma concentration range of 506000 ng/mL. The mean extraction recoveries for tetracycline and IS from plasma were 92.14 and 94.04, respectively. Method validation investigated parameters such as the linearity, precision, accuracy, specificity, and stability, giving results within the acceptable range. The proposed method was successfully applied for determination of tetracycline in human plasma samples to support bioequivalence studies.

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