An efficient synthesis of δ-(L-α-aminoadipyl)-L-seryl-D-valine (LLD ASV), a naturally occuring tripeptide from the fermentation of Penicillium chrysogenum
1988 ◽
Vol 53
(11)
◽
pp. 2854-2856
Keyword(s):
The synthesis of δ-(L-α-aminoadipyl)-L-seryl-D-valine (LLD ASV), a naturally occuring congener of the well known tripeptide δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (LLD ACV) which is the linear precursor of isopenicillin N, penicillin N, cephalosporin C is described. An efficient method for producing the requisite α-monobenzyl ester of N-benzyloxycarbonyl-L-homoglutamic acid for subsequent condesation at the side chain δ-carboxy group is presented.
2014 ◽
Vol 662
◽
pp. 59-62
Keyword(s):
2006 ◽
Vol 73
(3)
◽
pp. 962-970
◽
2003 ◽
Vol 43
(4)
◽
pp. 287-300
◽
Keyword(s):
1989 ◽
Vol 65
(1-2)
◽
pp. 71-75
◽
2015 ◽
Vol 1083
◽
pp. 51-54
◽
Keyword(s):