AB0343 A high serum level of haptoglobin is associated with the response of 12 weeks methotrexate therapy in recent-onset rheumatoid arthritis patients

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 657.7-657
Author(s):  
W. Tan ◽  
F. Wang ◽  
D. Guo ◽  
Y. Ke ◽  
Y. Shen ◽  
...  
2008 ◽  
Vol 10 (2) ◽  
pp. R28 ◽  
Author(s):  
Silje W Syversen ◽  
Guro L Goll ◽  
Espen A Haavardsholm ◽  
Pernille Bøyesen ◽  
Tor Lea ◽  
...  

2020 ◽  
Vol 21 (4) ◽  
pp. 1219 ◽  
Author(s):  
Hyung Muk Choi ◽  
Hari Madhuri Doss ◽  
Kyoung Soo Kim

Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and low-molecular weight isoforms. Numerous studies have demonstrated its insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects. Additionally, decreased serum levels of adiponectin is associated with chronic inflammation of metabolic disorders including Type 2 diabetes, obesity, and atherosclerosis. However, recent studies showed that adiponectin could have pro-inflammatory roles in patients with autoimmune diseases. In particular, its high serum level was positively associated with inflammation severity and pathological progression in rheumatoid arthritis, chronic kidney disease, and inflammatory bowel disease. Thus, adiponectin seems to have both pro-inflammatory and anti-inflammatory effects. This indirectly indicates that adiponectin has different physiological roles according to an isoform and effector tissue. Knowledge on the specific functions of isoforms would help develop potential anti-inflammatory therapeutics to target specific adiponectin isoforms against metabolic disorders and autoimmune diseases. This review summarizes the current roles of adiponectin in metabolic disorders and autoimmune diseases.


2011 ◽  
Vol 61 (8) ◽  
pp. 491-494 ◽  
Author(s):  
Mneimneh Wadad ◽  
Olivier Farges ◽  
Pierre Bedossa ◽  
Jacques Belghiti ◽  
Valérie Paradis

Tumor Biology ◽  
2015 ◽  
Vol 36 (12) ◽  
pp. 9215-9222 ◽  
Author(s):  
Ondrej Fiala ◽  
Milos Pesek ◽  
Jindrich Finek ◽  
Ondrej Topolcan ◽  
Jaroslav Racek ◽  
...  

1991 ◽  
Vol 41 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Hui-Jun Duan ◽  
Nobuo Itoh ◽  
Osamu Yamagami ◽  
Tsutomu Katsuyama ◽  
Hidekazu Shigematsu

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