scholarly journals A9.18 Potential Therapeutic Application of Human Umbilical Cord wharton Jelly Derived Mesenchymal Stem Cells in Primary Sjögren’s Syndrome

2013 ◽  
Vol 72 (Suppl 1) ◽  
pp. A71.1-A71
Author(s):  
Alessia Alunno ◽  
Pia Montanucci ◽  
Sara Caterbi ◽  
Onelia Bistoni ◽  
Giuseppe Basta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Human Umbilical Cord ◽  
Primary Sjogren’S Syndrome ◽  
Therapeutic Application ◽  
Primary Sjögren's Syndrome ◽  
Potential Therapeutic Application

Immunoregulatory effects of dental mesenchymal stem cells on T and B lymphocyte responses in primary Sjögren's syndrome

Immunotherapy ◽  
2022 ◽  
Author(s):  
Deniz Genç ◽  
Burcu Günaydın ◽  
Serhat Sezgin ◽  
Akın Aladağ ◽  
Emine Figen Tarhan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
B Cell ◽  
Mononuclear Cells ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Lymphocyte Responses

Background: In this article, the authors investigate the modulatory effects of dental mesenchymal stem cells (MSCs) on lymphocyte responses in primary Sjögren's syndrome (pSS), which is an autoimmune disease resulting from keratoconjunctivitis sicca and xerostomia. Methods: Mononuclear cells isolated from pSS patients cultured with or without dental MSCs and analyzed for lymphocyte responses via flow cytometry. Results: Dental-follicle (DF)- and dental-pulp (DP)-MSCs downregulated CD4+ T lymphocyte proliferation by increasing Fas-ligand expression on T lymphocytes and FoxP3 expressing Tregs, and decreasing intracellular IFN-γ and IL-17 secretion in pSS patients. DF-MSCs decreased the plasma B cell ratio in the favor of naive B cell population in pSS patients' mononuclear cells. Conclusion: DF- and DP-MSCs can be the new cellular therapeutic candidates for the regulation of immune responses in pSS.

scholarly journals Mesenchymal Stem Cells in Primary Sjögren’s Syndrome: Prospective and Challenges

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Weiqian Chen ◽  
Ye Yu ◽  
Jilin Ma ◽  
Nancy Olsen ◽  
Jin Lin
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Primary Sjögren’s syndrome (pSS) is a chronic systemic inflammatory autoimmune disease characterized by lymphocytic infiltrates in exocrine glands. Current approaches do not control harmful autoimmune attacks or prevent irreversible damage and have considerable side effects. Mesenchymal stem cells (MSCs) have been effective in the treatment of several autoimmune diseases. The objective of this review is to illustrate the potential therapeutic role of MSCs in pSS. We summarize the recent advances in what is known about their immunomodulatory function and therapeutic applications in pSS. MSC transfusion can suppress autoimmunity and restore salivary gland secretory function in mouse models and patients with pSS by inducing regulatory T cells, suppressing Th1, Th17, and T follicular helper cell responses. In addition, MSCs can differentiate into salivary epithelial cells, presenting an option as a suitable alternative treatment. We also discuss current bioengineering methods which improve functions of MSCs for pSS. However, there remain many challenges to overcome before their wide clinical application.

scholarly journals Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome

2018 ◽  
Vol 71 (1) ◽  
pp. 133-142 ◽  
Author(s):  
Sarah Pringle ◽  
Xiaoyan Wang ◽  
Gwenny M. P. J. Verstappen ◽  
Janneke H. Terpstra ◽  
Clarence K. Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome
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