OP0202-PC Use of Over-the-Counter Non-Steroidal Anti-Inflammatory Drugs in the General Population and in Patients with a High Risk of Adverse Drug Events

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A120.3-A121 ◽  
Author(s):  
A. Koffeman ◽  
V. Valkhoff ◽  
S. Çelik ◽  
G. 't Jong ◽  
M. Sturkenboom ◽  
...  
Keyword(s):  
High Risk ◽  
General Population ◽  
Adverse Drug Events ◽  
Over The Counter ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals High-risk use of over-the-counter non-steroidal anti-inflammatory drugs: a population-based cross-sectional study

2014 ◽  
Vol 64 (621) ◽  
pp. e191-e198 ◽  
Author(s):  
Aafke R Koffeman ◽  
Vera E Valkhoff ◽  
Sevde Çelik ◽  
Geert W ’t Jong ◽  
Miriam CJM Sturkenboom ◽  
...  
Keyword(s):  
High Risk ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Over The Counter ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Phenanthrenes in Chinese Yam Peel Exhibit Anti-inflammatory Activity, as Shown by Strong in Vitro Cyclooxygenase Enzyme Inhibition

2016 ◽  
Vol 11 (9) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Qian Li ◽  
Chuan-Rui Zhang ◽  
Amila A. Dissanayake ◽  
Qun-yu Gao ◽  
Muraleedharan G. Nair
Keyword(s):  
Food Item ◽  
Inflammatory Activity ◽  
Spectroscopic Methods ◽  
Over The Counter ◽  
Chinese Yam ◽  
Inflammatory Drugs ◽  
In Vitro Bioassays ◽  
Anti Inflammatory ◽  
Cox 1

Chinese yam ( Dioscorea opposita), peeled or whole, is a popular food item that is considered to be healthy. Often, the yam is peeled before cooking. However, it is also consumed with peel. Therefore, in this study, the peel of this yam was extracted sequentially with n-hexane, ethyl acetate and methanol, and studied for its health-benefits, using in vitro bioassays. Bioactivity-guided purifications of extracts of the peel afforded phenanthrenes (1-4), as characterized by spectroscopic methods. Phenanthrene 1 is a novel analogue. The extracts and isolates were tested for anti-inflammatory activity using cyclooxygenase enzyme (COX-1 and -2) inhibitory assays. All phenanthrenes isolated from the yam peel showed higher inhibition of COX enzymes than the over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, ibuprofen and naproxen.

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