THU0396 Six Months of Sclerostin Antibody Treatment in Cynomolgus Monkeys: Sustained Improvements in Vertebral Microarchitecture and Bone Strength Following a Temporal Increase in Cancellous Bone Formation

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A299.2-A299
Author(s):  
M. S. Ominsky ◽  
R. Samadfam ◽  
J. Jolette ◽  
S. Y. Smith ◽  
H. Z. Ke ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Strength ◽  
Cancellous Bone ◽  
Antibody Treatment ◽  
Cynomolgus Monkeys ◽  
Sclerostin Antibody

scholarly journals Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

2009 ◽  
Vol 24 (4) ◽  
pp. 578-588 ◽  
Author(s):  
Xiaodong Li ◽  
Michael S Ominsky ◽  
Kelly S Warmington ◽  
Sean Morony ◽  
Jianhua Gong ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Postmenopausal Osteoporosis ◽  
Bone Strength ◽  
Rat Model ◽  
Antibody Treatment ◽  
Sclerostin Antibody

scholarly journals Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass and Bone Strength of Intact Bones in Adult Male Rats

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Pui Kit Suen ◽  
Tracy Y. Zhu ◽  
Dick Ho Kiu Chow ◽  
Le Huang ◽  
Li-Zhen Zheng ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Bone Strength ◽  
Adult Male ◽  
Male Rats ◽  
Antibody Treatment ◽  
Sclerostin Antibody

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

2010 ◽  
Vol 25 (5) ◽  
pp. 948-959 ◽  
Author(s):  
Michael S Ominsky ◽  
Fay Vlasseros ◽  
Jacquelin Jolette ◽  
Susan Y Smith ◽  
Brian Stouch ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Strength ◽  
Bone Mineral ◽  
Mineral Density ◽  
Cynomolgus Monkeys ◽  
Sclerostin Antibody

Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus

2013 ◽  
Vol 28 (3) ◽  
pp. 627-638 ◽  
Author(s):  
Christine Hamann ◽  
Martina Rauner ◽  
Yvonne Höhna ◽  
Ricardo Bernhardt ◽  
Jan Mettelsiefen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Mass ◽  
Bone Strength ◽  
Bone Defect ◽  
Antibody Treatment ◽  
Sclerostin Antibody

scholarly journals Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone

2011 ◽  
Vol 63 (8) ◽  
pp. 2385-2395 ◽  
Author(s):  
M. Marenzana ◽  
K. Greenslade ◽  
A. Eddleston ◽  
R. Okoye ◽  
D. Marshall ◽  
...  
Keyword(s):  
Bone Strength ◽  
Growth Retardation ◽  
Antibody Treatment ◽  
Sclerostin Antibody ◽  
Young Mice
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