FRI0027 MRI-Proven Bone Marrow Oedema at Baseline is the Strongest Predictor Toward the Development of Rapid Radiographic Progression at 1 Year in Patients with Early-Stage Rheumatoid Arthritis: Results from Nagasaki University Early Arthritis Cohort

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 428.1-428
Author(s):  
Y. Nakashima ◽  
M. Tamai ◽  
J. Kita ◽  
S. Tuji ◽  
S. Fukui ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Marrow ◽  
Radiographic Progression ◽  
Early Stage ◽  
Early Arthritis ◽  
Bone Marrow Oedema

MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression

2010 ◽  
Vol 70 (3) ◽  
pp. 428-433 ◽  
Author(s):  
Pernille Bøyesen ◽  
Espen A Haavardsholm ◽  
Mikkel Østergaard ◽  
Désirée van der Heijde ◽  
Sølve Sesseng ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Marrow ◽  
Early Rheumatoid Arthritis ◽  
Radiographic Progression ◽  
Bone Marrow Oedema ◽  
Tender Joint Count ◽  
X Rays ◽  
Tender Joint ◽  
Reactive Protein

ObjectivesTo determine whether MRI and conventional (clinical and laboratory) measures of inflammation can predict 3-year radiographic changes measured by the van der Heijde Sharp score in patients with early rheumatoid arthritis (RA).Methods55 patients with RA with disease duration <1 year participated in this 3-year follow-up study. Patients were evaluated at baseline, 3, 6, 12 and 36 months by swollen and tender joint count, disease activity score based on 28-joint count, erythrocyte sedimentation rate (ESR), C reactive protein, MRI measures of synovitis, bone marrow oedema and tenosynovitis of the dominant wrist, as well as conventional x-rays of the hands and wrists.ResultsAll measures of inflammation decreased during the follow-up period. ESR, MRI synovitis and MRI bone marrow oedema were independent predictors of 3-year radiographic progression adjusted for age, sex and anti-citrullinated protein antibodies. The 1-year cumulative measures of MRI synovitis and bone marrow oedema provided an improved explanation of variation (adjusted R2) in radiographic change compared with the baseline MRI values (adjusted R2=0.32 and 0.20 vs 0.11 and 0.04, respectively).ConclusionsBoth baseline and 1-year cumulative measures of MRI synovitis and bone marrow oedema independently predicted 3-year radiographic progression. These results confirm that MRI synovitis and MRI bone marrow oedema precede radiographic progression in patients with early RA.

Magnetic Resonance Imaging Bone Edema at Enrollment Predicts Rapid Radiographic Progression in Patients with Early RA: Results from the Nagasaki University Early Arthritis Cohort

2016 ◽  
Vol 43 (7) ◽  
pp. 1278-1284 ◽  
Author(s):  
Yoshikazu Nakashima ◽  
Mami Tamai ◽  
Junko Kita ◽  
Toru Michitsuji ◽  
Toshimasa Shimizu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Radiographic Progression ◽  
Bone Erosion ◽  
Early Stage ◽  
Early Arthritis ◽  
Resonance Imaging ◽  
Multivariate Logistic Regression ◽  
Bone Edema

Objective.To clarify whether magnetic resonance imaging (MRI) bone edema predicts the development of rapid radiographic progression (RRP) in the Nagasaki University Early Arthritis Cohort of patients with early-stage rheumatoid arthritis (RA).Methods.Patients with early-stage RA (n = 76) were enrolled and underwent 1.5-T MRI of both wrists and finger joints. Synovitis, bone edema, and bone erosion were evaluated using the Rheumatoid Arthritis Magnetic Resonance Imaging Scoring (RAMRIS). RRP was defined as an annual increment > 3 at 1 year by the Genant-modified Sharp score of plain radiographs. A multivariate logistic regression analysis was performed to establish the risk factors for RRP.Results.Median disease duration at enrollment was 3 months. RRP was found in 12 of the 76 patients at 1 year. A univariate analysis revealed that matrix metalloprotease-3, RAMRIS bone edema score, and RAMRIS bone erosion score were associated with RRP. Multivariate logistic regression analyses demonstrated that the RAMRIS bone edema score at enrollment (5-point increase, OR 2.18, 95% CI 1.32–3.59, p = 0.002) was the only independent predictor of the development of RRP at 1 year. A receiver-operating characteristic analysis identified the best cutoff value for RAMRIS bone edema score as 5. RRP was significantly rare among the patients with a RAMRIS bone edema score < 5 at enrollment (2 from 50 patients).Conclusion.Our findings suggest that MRI bone edema is closely associated with the development of RRP in patients with early-stage RA. Physicians should carefully control the disease activity when MRI bone edema is observed in patients with early RA.

scholarly journals Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow edema and power-Doppler grade ≥2 articular synovitis in rheumatoid arthritis: retrospective observational study

2020 ◽  
Author(s):  
Ayuko Takatani ◽  
Mami Tamai ◽  
Nozomi Ohki ◽  
Momoko Okamoto ◽  
Yushiro Endo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Marrow ◽  
Bone Marrow Edema ◽  
Radiographic Progression ◽  
Early Stage ◽  
Power Doppler ◽  
University Hospital ◽  
Treat To Target ◽  
Magnetic Resonance Imaging Mri ◽  
Marrow Edema

Abstract Background : Recently, it is well known the utility of both magnetic resonance imaging (MRI) and ultrasound (US) for rheumatoid arthritis (RA) in clinical practice. To investigate the favorable timing for monitoring of RA by MRI and US for predicting the radiographic progression during a treat-to-target (T2T) strategy. Methods : Symptomatic wrist and finger joints of 44 active RA patients (median disease duration 8.5 months), recruited in Nagasaki University Hospital from January 2010 to June 2017, were examined by MRI and US at baseline and then at 3-month (US) and 6-month intervals (MRI). The T2T strategy was used through 1 year. MRI was evaluated by RA MRI scoring (RAMRIS) and US by Outcomes Measures in Rheumatology Clinical Trial (OMERACT), respectively. Plain radiographs were assessed by the Genant-modified Sharp score for the symptomatic side. Radiographic progression was defined as an annual increase ≥0.75 at 1 year. Factors associated with radiographic progression were analyzed. The optimal use of MRI and US at each timepoint was considered. Results : Disease activity score (DAS) 28-ESR as well as inflammatory findings of MRI-proven bone marrow edema (BME) and US power-Doppler (PD) signal were reduced during treatment. A logistic regression model revealed that MRI-proven BME at baseline and 6 months and joint counts of PD grade ≥2 synovitis at 3 or 6 months are significantly associated with radiographic progression at 1 year. Conclusions : The combination of MRI and US at each timepoint may help predict radiographic progression in patients with early-stage RA during T2T strategies.

SAT0082 Evaluation of definitions of rheumatoid arthritis remission by assessing radiographic progression in the leiden early arthritis cohort

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 497.3-498
Author(s):  
A.H.M. van der Helm-van Mil ◽  
R. Knevel ◽  
F. Qureshi ◽  
W.C. Manning ◽  
G. Cavet ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Radiographic Progression ◽  
Early Arthritis
Sign in / Sign up

Export Citation Format

Share Document