scholarly journals Systematic analysis of COVID-19 infection and symptoms in a systemic lupus erythematosus population: correlation with disease characteristics, hydroxychloroquine use and immunosuppressive treatments

2020 ◽  
pp. annrheumdis-2020-218244 ◽  
Author(s):  
Zoé Gendebien ◽  
Christian von Frenckell ◽  
Clio Ribbens ◽  
Béatrice André ◽  
Marie Thys ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Systematic Analysis ◽  
Disease Characteristics ◽  
Population Correlation

scholarly journals Depression and medication nonadherence in childhood-onset systemic lupus erythematosus

Lupus ◽  
2018 ◽  
Vol 27 (9) ◽  
pp. 1532-1541 ◽  
Author(s):  
A M Davis ◽  
T B Graham ◽  
Y Zhu ◽  
M L McPheeters
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Medication Adherence ◽  
Lupus Erythematosus ◽  
Depression Symptoms ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Medication Nonadherence ◽  
Disease Characteristics ◽  
Prevalence Of Depression ◽  
Onset Systemic Lupus Erythematosus

Objectives Depression and medication nonadherence are important in managing chronic diseases, but little is known about these factors in childhood-onset systemic lupus erythematosus (cSLE). The objectives of this cross-sectional study were to estimate prevalence of depression and medication nonadherence, describe demographic and disease characteristics associated with depression and medication nonadherence, and evaluate the association between depression and medication nonadherence in cSLE patients. Methods Patients with cSLE ( n = 51) completed validated screening questionnaires to identify depression and medication nonadherence, Patient Health Questionnaire-9 and Medication Adherence Self-Report Inventory, respectively. Demographic and disease characteristics were obtained via chart abstraction, and compared between groups of depression or medication nonadherence status. A multivariable linear regression model adjusting for propensity scores was conducted to evaluate the association between depression and medication nonadherence. Results The prevalence of a positive depression screen was 58.8%, and seven patients reported suicidal ideation (13.7%). The prevalence of self-reported medication nonadherence was 19.7%. No statistically significant differences for demographic and disease characteristics were found between patients with a positive vs. negative depression screen. Patients reporting medication nonadherence were more likely to have longer disease duration (4.8 vs. 2.6 years, p = 0.035). As the severity of depression symptoms increased, the degree of medication nonadherence also increased (beta = –1.89; p = 0.011). Conclusions The prevalence of depression and medication nonadherence is high in cSLE, and these factors have a direct relationship. Interventions that better recognize and treat depression and increase rates of medication adherence are needed to improve outcomes in cSLE.

scholarly journals High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus

2011 ◽  
Vol 13 (3) ◽  
pp. R71 ◽  
Author(s):  
Deena A Abdulahad ◽  
Johanna Westra ◽  
Johannes Bijzet ◽  
Pieter C Limburg ◽  
Cees GM Kallenberg ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
High Mobility ◽  
High Mobility Group ◽  
Systemic Lupus ◽  
Disease Characteristics

scholarly journals Disease characteristics and causes of early and late death in a group of Croatian patients with systemic lupus erythematosus deceased over a 10-year period

2018 ◽  
Vol 59 (1) ◽  
pp. 3-12 ◽  
Author(s):  
Ivan Padjen ◽  
Mislav Cerovec ◽  
Marijan Erceg ◽  
Miroslav Mayer ◽  
Ranko Stevanović ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Late Death ◽  
Disease Characteristics

scholarly journals THU0283 DISTINCT CLINICAL FEATURES OF LATE–ONSET SYSTEMIC LUPUS ERYTHEMATOSUS AMONG MALAYSIAN MULTI-ETHNIC COHORT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 368.2-369
Author(s):  
S. S. Shaharir ◽  
M. S. Mohamed Said ◽  
S. Rajalingham ◽  
H. Mahadzir ◽  
R. Mustafar ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Age Group ◽  
Systemic Lupus ◽  
Disease Characteristics ◽  
Younger Age ◽  
Damage Accrual ◽  
Onset Group ◽  
Onset Systemic Lupus Erythematosus

Background:Systemic Lupus Erythematosus (SLE) commonly affects young women in their reproductive age group. However, there is an increase prevalence of late-onset SLE, parallel to the higher life expectancies among general populations worldwide. It has been reported that up to 25% SLE populations have a later onset of disease and their disease expression and course may be different.Objectives:To determine the clinical features and outcomes of late-onset SLE patients in a multi-ethnic Malaysian cohort.Methods:Medical records of SLE patients who attended regular follow-up clinics in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) from 2011 until June 2019 were reviewed. Late-onset SLE was defined as the onset of SLE symptoms or diagnosis after the age of 50 years old. Information on their socio-demographics and disease characteristics were obtained from the clinical records. Disease damage was assessed using the SLICC/ACR (Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index (SDI) scores. The disease characteristics and autoantibody profiles were compared between late-onset and younger onset patients. Damage accrual at disease onset and at 5 years was obtained and compared between the two groups.Results:A total of 429 patients were included and majority of them were Malays (n= 225, 52.4%) followed by Chinese (n=180, 42), Indian (n=21, 4.9%) and others (n=3,0.7%). This multi-ethnic SLE cohort was consisted of predominantyly female patients (n=372,86.7%) with disease duration of 9.9 years ± 6.8 years. A total of 13.8% (n=59) had late onset SLE with mean onset of disease at 58.1 ± 6.3 years while younger group was 27.2 ± 9.4 years. The commonest system involvement among the late-onset group was haematological manifestation (69.5%).Compared to the younger-onset SLE, late-onset SLE occurred significantly higher among the Chinese (66.1%) as compared to Malay (32.3%), Indians and other ethnics (1.7%), p<0.01. Patients with late-onset SLE also had significantly less musculoskeletal (37.3% vs 62.4%) and renal (23.7% vs 71.1%), p<0.001 and tend to have less muco-cutanoues manifestations (28.8 vs 42.4%, p=0.06). Meanwhile, pulmonary involvement was more common among the late onset SLE patients (11.9% vs 0.8%, p<0.001). Extractable nuclear antigen (ENA) results were available in 197 patients and patients with late-onset SLE had significantly higher rate of anti-RO positive (63% vs 3.9%), p=0.01. Otherwise, no significant difference in the other autoantibodies expressions including anti-La, anti-Sm, anti-RNP, anti-ribosomal P and anti-phospholipid antibodies. Patients with late-onset SLE tend to have more damage accrual at 5 years as compared to the younger age group (p=0.07). The mortality in the late onset group was 13.6% (n=8) as compared to 2.7% (n=10) in the younger age group, p=0.01. Majority of the cause of death in the later onset SLE was infection (87.5%) while in the younger age group was infection and active disease (90%).Conclusion:Late onset SLE occurs more commonly among Chinese ethnics in Malaysia and Malaysian SLE patients with late onset of the disease have distinct clinical manifestations. Damage accrual at 5 years tend to be higher in the late-onset group and the mortality is significantly higher with the major cause of death is infection. The different disease expression and outcome in late onset SLE suggest different factors in influencing the disease course and hence further studies including their genetic profiles are warranted.References:[1]Paula I. Burgos; Graciela S. Alarcón. Late-onset Lupus: Facts and Fiction. Future Rheumatol. 2008;3(4):351-356.[2]S Stefanidou, C Gerodimos, A Benos et al. Clinical expression and course in patients with late onset systemic lupus erythematosus. Hippokratia. 2013; 17(2): 153–156.Acknowledgments:This research was supported by the “Fundamental Research Grant Scheme (FRGS/1/2018/SKK02/UKM/03/1)” by Ministry of Education MalaysiaDisclosure of Interests:Syahrul Sazliyana Shaharir: None declared, Mohd Shahrir Mohamed Said: None declared, Sakthiswary Rajalingham Speakers bureau: Pfizer (500USD), Hazlina Mahadzir: None declared, Ruslinda Mustafar: None declared, Asrul Abdul Wahab: None declared

scholarly journals Disease characteristics in patients with juvenile- and adult-onset systemic lupus erythematosus: A multi-center comparative study

2021 ◽  
Author(s):  
Sherif M Gamal ◽  
Nermeen Fouad ◽  
Nora Yosry ◽  
Wael Badr ◽  
Nesreen Sobhy
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mortality Rate ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Damage Index ◽  
Adult Onset ◽  
Systemic Lupus ◽  
Disease Characteristics ◽  
Onset Systemic Lupus Erythematosus

Objectives: This study aims to compare disease characteristics in patients with juvenile-onset systemic lupus erythematosus (JSLE) and adult-onset systemic lupus erythematosus (ASLE). Patients and methods: Between June 2010 and March 2020, a total of 186 patients with JSLE (23 males, 163 females; median age: 25 years; range, 20 to 30.3 years) and 236 patients with ASLE (23 males, 213 females; median age: 35 years; range, 29 to 40 years) were retrospectively analyzed. Clinical and laboratory data, treatment received, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics (SLICC)/ACR Damage Index (SDI) scores, comorbidities and deaths were compared between the groups. Results: The JSLE patients showed statistically significant higher constitutional manifestations, cardiac manifestations, serositis, nephritis, end-stage renal disease, neurological manifestations, gastrointestinal manifestations, secondary vasculitis, Raynaud’s, livedo-reticularis, dry mouth, dry eye, ocular manifestations, avascular necrosis, hematological manifestations, and hypocomplementemia (p<0.001, p=0.016, p=0.005, p=0.001, p=0.04, p<0.001, p<0.001, p<0.001, p=0.002, p=0.043, p=0.004, p=0.03, p<0.001, p=0.01, p<0.001, and p=0.001, respectively). Median SLEDAI scores were statistically significant higher in the JSLE group, both at onset (p<0.001) and in the final follow-up visit (p<0.001). Median SLICC scores were also higher in the JSLE group (p<0.001). Mycophenolate mofetil and intravenous pulse steroids were more frequently used in the juvenile group (p<0.001 and p=0.03, respectively). Hypertension, dyslipidemia, and avascular necrosis were found to be statistically significantly higher in the JSLE group (p<0.001, p=0.006, and p=0.01, respectively). The mortality rate was statistically significantly higher in the JSLE group than the ASLE group (p<0.001). Conclusion: The JSLE patients showed more serious manifestations, higher disease activity, higher damage index, and mortality rate compared to ASLE patients. These results suggest the need of a regular follow-up and close surveillance of JSLE patients.

Anti-IFI16 antibodies and their relation to disease characteristics in systemic lupus erythematosus

Lupus ◽  
2013 ◽  
Vol 22 (6) ◽  
pp. 607-613 ◽  
Author(s):  
V Caneparo ◽  
T Cena ◽  
M De Andrea ◽  
V Dell'Oste ◽  
P Stratta ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Disease Characteristics
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