OP0311 THE ROLE OF COMORBID PATHOLOGY IN THE PROGRESSIVE COURSE OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS

Background:ANCA-associated systemic vasculitis (AAV) is characterized by a high incidence of complications and high damage index. Comorbid pathology at the onset can significantly worsen the prognosis AAV. The most significant comorbid conditions in patients with AAV are coronary artery disease, hypertension and dyslipidemia.Objectives:The aim of this study was to determine the role of comorbid pathology in the progressive course in patients with AAV.Methods:Patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) were observed during the first 3 years of the disease and included in this study between 2010 and 2018. At the onset of AAV 75% of patients had significant comorbidities (coronary artery disease, hypertension, dyslipidemia, chronic obstructive pulmonary disease, peptic ulcer, diabetes mellitus, autoimmune thyroiditis and others).Results:In total 209 (165 [79%] female and mean age 51.8 ± 13.2 years) AAV patients (94 GPA; 46 MPA; and 69 EGPA) were included in the analysis. Formation of chronic kidney disease was significantly more frequent in the group of AAV patients with hypertension at the onset, than in patients without hypertension (respectively 37% and 23.6%, p=0.041). Development of thromboembolic complications was significantly more frequent in the group of AAV patients with coronary artery disease at the onset of AAV, than in patients without coronary artery disease (respectively 34% and 14.8%, p=0.034). Dyslipidemia also was risk factor for cardiovascular complications (OR – 3.81, 95% CI (2.43; 8.2) p=0.009). Presence of diabetes mellitus in the AAV onset was risk factor for infectious complications (OR – 1.77, 95% CI (1.14; 3.45) p=0.038).Conclusion:Our study has shown that comorbid pathology increase risk of serious complications and can significantly worsen the prognosis AAV. Prevention of development of comorbid conditions and control of lipid levels, hypertension levels are necessary to prevent the formation of irreversible organ damage.Disclosure of Interests:None declared.