G118(P) Associations between postnatal growth rates and cognitive outcomes at age 16 years in infants born small-for-gestational-age at term

Fetal growth retardation is associated with decreased postnatal growth, resulting in a lower adult height. In addition, a low birth weight is associated with an increased risk of developing diseases during adulthood, such as insulin resistance, type 2 diabetes mellitus, hypertension, dyslipidemia, and cardiovascular diseases. Children with persistent postnatal growth retardation, i.e., incomplete catchup growth, can be treated with human GH. The GH/IGF-I axis is involved in the regulation of carbohydrate and lipid metabolism. The question of whether treatment with GH in children born small for gestational age (SGA) has long-term implications with respect to glucose/insulin and lipid metabolism has not been answered yet. In this article, the available data are reviewed.

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The Optimal Postnatal Growth Trajectory for Term Small for Gestational Age Babies: A Prospective Cohort Study

The Journal of Pediatrics ◽

10.1016/j.jpeds.2014.09.025 ◽

2015 ◽

Vol 166 (1) ◽

pp. 54-58.e3 ◽

Cited By ~ 36

Author(s):

Xiaoping Lei ◽

Yan Chen ◽

Jiangfeng Ye ◽

Fengxiu Ouyang ◽

Fan Jiang ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Gestational Age ◽

Small For Gestational Age ◽

Prospective Cohort ◽

Postnatal Growth ◽

Growth Trajectory

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Birth Size, Postnatal Growth and Growth during Growth Hormone Treatment in Small-for-Gestational-Age Children: Associations with IGF1 Gene Polymorphisms and Haplotypes?

Hormone Research ◽

10.1159/000224336 ◽

2009 ◽

Vol 72 (1) ◽

pp. 15-24 ◽

Cited By ~ 6

Author(s):

Wietske A. Ester ◽

Joyce B. van Meurs ◽

Nicolette J. Arends ◽

André G. Uitterlinden ◽

Maria A. de Ridder ◽

...

Keyword(s):

Growth Hormone ◽

Gestational Age ◽

Small For Gestational Age ◽

Gene Polymorphisms ◽

Growth Hormone Treatment ◽

Hormone Treatment ◽

Postnatal Growth ◽

Birth Size ◽

I Gene

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Role of insulin-like gRowth factoR-1 in fetal and eaRly postnatal gRowth in childRen boRn small foR gestational age

The Bulletin of Contemporary Clinical Medicine ◽

10.20969/vskm.2013.6(6).36-39 ◽

2013 ◽

Vol 6 (6) ◽

pp. 36-39

Author(s):

Kristina F. islamova ◽

◽

YurY v . PetrenKo ◽

DmitrY o. ivanov ◽

soFia n. FiliPPova ◽

...

Keyword(s):

Growth Factor ◽

Gestational Age ◽

Small For Gestational Age ◽

Postnatal Growth ◽

Insulin Like Growth Factor

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Postnatal growth in children born small for gestational age with and without smoking mother

Pediatric Research ◽

10.1038/s41390-019-0352-5 ◽

2019 ◽

Vol 85 (7) ◽

pp. 961-966

Author(s):

Linda Lindström ◽

Anna-Karin Wikström ◽

Eva Bergman ◽

Ajlana Mulic-Lutvica ◽

Ulf Högberg ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Postnatal Growth ◽

Smoking Mother

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Hormonal regulation of postnatal growth from birth to age six months in Small-for-Gestational - Age children

Pediatrician (St Petersburg) ◽

10.17816/ped73104-110 ◽

2016 ◽

Vol 7 (3) ◽

pp. 104-110

Author(s):

Kristina F Islamova ◽

Dmitriy O Ivanov ◽

Yuriy V Petrenko ◽

Elizaveta A Kurzina

Keyword(s):

Insulin Sensitivity ◽

Gestational Age ◽

Small For Gestational Age ◽

Hormonal Regulation ◽

Later Life ◽

Postnatal Growth ◽

Blood Levels ◽

Model Assessment ◽

Appropriate For Gestational Age ◽

Catch Up

This article is devoted to the investigation hormonal mechanisms of postnatal growth from birth to age six months in small for gestational age children (SGA) with asymmetrical and asymmetrical IUGR. The IGF-1 and GH levels, insulin sensitivity (by homeostasis model assessment (HOMA-IR)) were measured blood at 3 and 6 months of age. The prospective study includes 40 SGA infants (group 1) - 24 - with asymmetrical (1a) and 16 with symmetrical IUGR babies (1b) and 17 appropriate for gestational age (AGA) infants (group 2). Most SGA infants showed rapid, or “catch-up” postnatal growth. Symmetrical IUGR infants with “catch-up” growth had higher IGF-1 and growth GH levels at 3 month of age than asymmetrical IUGR with “catch-up” growth (p < 0,05). From 3 to 6 months of age 77 % of infants with “catch-up” growth showed retardation of growth velocity. At 6 month of age SGA infants with “catch-up” growth had lower IGF-1, GH blood levels and HOMA-IR than at 3 months of age (p < 0,05). Infants without “catch-up” growth had similar hormone levels at 3 and 6 months of age. We suppose, that these changes of “GH - IGF-1” axis and insulin sensitivity at age 3 and 6 months in SGA infants are the mechanisms, which promote the postnatal growth. It can be assumed that the same mechanisms may underlie metabolic disorders in later life.

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