scholarly journals Haemoglobin and red blood cell reference intervals during infancy

2021 ◽  
pp. archdischild-2021-321672
Author(s):  
Sara Marie Larsson ◽  
Lena Hellström-Westas ◽  
Andreas Hillarp ◽  
Pia Karlsland Åkeson ◽  
Magnus Domellöf ◽  
...  
Keyword(s):  
Blood Cell ◽  
Umbilical Cord ◽  
Red Blood Cell ◽  
Haemoglobin Concentration ◽  
Reference Intervals ◽  
Mean Cell Volume ◽  
Cord Clamping ◽  
Healthy Infants ◽  
Umbilical Cord Clamping ◽  
Definition Of

ObjectivesThere is a need for updated haematological reference data in infancy. This study aimed to define intervals for haemoglobin and red blood cell biomarkers based on data from a large cohort of longitudinally followed Swedish infants.DesignLongitudinal cohort study.SettingTwo Swedish study centres.ParticipantsThree community-based populations including 442 presumably healthy infants born at term and with umbilical cord clamping delayed to 30 s or more after birth.MethodsBlood samples were collected from umbilical cord blood (a), at 48–118 hours (b), at 4 months (c) and at 12 months (d). Reference intervals as the 2.5th and 97.5th percentiles were calculated in coherence with Clinical and Laboratory Standards Institute guidelines.ResultsReference intervals for haemoglobin (g/L) were: (a) 116–189, (b) 147–218, (c) 99–130, (d) 104–134, and for mean cell volume (fL): (a) 97–118, (b) 91–107, (c) 71–85, (d) 70–83. Reference intervals for erythrocyte counts, reticulocyte counts, reticulocyte haemoglobin, mean cell haemoglobin and mean cell haemoglobin concentration were also estimated. According to the WHO definition of anaemia, a haemoglobin value less than 110 g/L, 16% of this presumably healthy cohort could be classified as anaemic at 12 months.ConclusionWe found mainly narrower reference intervals compared with previously published studies. The reference intervals for each parameter varied according to the infants’ age, demonstrating the necessity of age definitions when presenting infant reference intervals. The discrepancy with the WHO classification for anaemia at 12 months, despite favourable conditions in infancy, needs future investigation.

scholarly journals A study of effect of delayed and early umbilical cord clamping on neonatal haemoglobin status

2021 ◽  
Vol 10 (6) ◽  
pp. 2268
Author(s):  
Jyoti Jaiswal ◽  
Krishna Kumar Dehariya ◽  
Devina Nagraj
Keyword(s):  
Haemoglobin Level ◽  
Umbilical Cord ◽  
Delayed Cord Clamping ◽  
Cord Clamping ◽  
Wide Range ◽  
Significant Difference ◽  
Early Cord Clamping ◽  
Umbilical Cord Clamping ◽  
Neonatal Blood ◽  
Definition Of

Background: Delayed cord clamping has been supported by physician because it allows for physiological transfer of blood from placenta to the infant and thus permits placenta to newborn transfusion and results in an increased neonatal blood volume at birth. At present there is no standard definition of delayed cord clamping. Clamping time varies significantly between studies and a wide range of parameters were used for clamping of cord.Methods: This was an observational study conducted in a public hospital among 200 uncomplicated full-term pregnancies where 100 each were present in early cord clamping (ECC) and delayed cord clamping (DCC) groups respectively and neonatal haematological parameters studied according to different cord clamping times.Results: There was a significant increase of mean haemoglobin level from 14.8 to 16.0 g/dl from 15 secs to 60 secs and gradual increase of mean haemoglobin level from 16.2 to 16.8 g/dl from 60 secs to 180 secs. There was a highly significant difference between ECC and DCC groups regarding mean haemoglobin level and MCH values. MCV and MCH values were also significantly different in both the groups.Conclusions: We concluded in this study that delayed cord clamping, resulted in improved haemoglobin and other haematocrit levels specially when cord was clamped after first 60 secs. Delayed clamping also reduced the prevalence of neonatal anaemia at 2 days of age. In terms of maternal outcomes, delayed umbilical cord clamping did not increase the risk of postpartum haemorrhage or the need for blood transfusion.

scholarly journals Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido

2017 ◽  
Vol 86 (4) ◽  
pp. 385-391
Author(s):  
Olga Aniołek ◽  
Agnieszka Barc ◽  
Anna Jarosińska ◽  
Zdzisław Gajewski
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Red Blood Cell ◽  
Blood Smear ◽  
Haemoglobin Concentration ◽  
Cell Distribution ◽  
Preventative Care ◽  
Mean Cell Volume ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Microcytosis is observed in healthy Japanese breed dogs. The aim of the study was to evaluate the frequency and intensity of asymptomatic anisocytosis using a three-grade scale in Japanese dog breeds with special emphasis on the following indices: mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, and red blood cell distribution width. The retrospective study included analyses of blood morphology and blood smear for clinically healthy Japanese dog breeds Shiba, Akita, and Hokkaido aged from 6 months to 14 years, performed as a part of preventative care. A total of 74 dogs of both sexes were qualified for the study. The group included both neutered and non-neutered animals (Akita – 17 females, 12 males, Shiba – 24 females, 18 males, Hokkaido – 2 females, 1 male). The blood smear revealed significant anisocytosis in 60.8% and mild anisocytosis in 28.4% of the tested dogs – 89.2% in total. Microcytosis was reported for 25.7% of the tested Japanese breed dogs. Reduced mean cell haemoglobin and mean cell haemoglobin concentration were diagnosed in 75.7% and 40.5% of dogs, respectively. Red blood cell distribution width as an anisocytosis indicator exceeded the norm in 12% of the tested dogs. Compared to mixed breed dogs, the Japanese breeds had a reduced mean cell volume, mean cell haemoglobin concentration and significant anisocytosis in the blood smear as well as a higher red blood cell distribution width indicator. Veterinarians should consider these differences when interpreting the results of morphological blood tests.

scholarly journals Confounding influences of malnutrition and Plasmodium falciparum and Schistosoma haematobium infections on haematological parameters in school children in Muyuka, Cameroon

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Irene Ule Ngole Sumbele ◽  
Ofon Vitalis Otia ◽  
Lorraine Francis ◽  
Orelien Sylvain Mtopi Bopda ◽  
Calvin Bisong Ebai ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Cell Count ◽  
Schistosoma Haematobium ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
Blood Cell Count ◽  
Malaria Parasites ◽  
Mean Cell Volume ◽  
Distribution Width

Abstract Background School-aged children (SAC) are a high-risk demographic group for infectious diseases and malnutrition. The objective of this study was to assess the burden and the effect of Plasmodium falciparum and Schistosoma haematobium infections on the haematological indices in SAC and the confounding influence of malnutrition on the outcomes. Methods This cross-sectional study was conducted in SAC 4–14 years old living in Ikata, Bafia and Mile 14-Likoko in Muyuka, Cameroon. Anthropometric measures of malnutrition were obtained and blood samples collected were used for detection of malaria parasites by Giemsa-stained blood films using light microscopy and complete blood count analysis using an automated haematology analyser. Urine samples collected were used to detect micro haematuria with the aid of reagent strips and the eggs of S. haematobium by urine filtration technique. Multiple linear regression model was used to examine influence of independent variables on haematological parameters. Results Out of the 606 SAC examined, the prevalence of single infections with Plasmodium or S. haematobium and co-infection with both parasites was 16.2, 16.3 and 8.3%, respectively. Overall, malaria parasite (MP), urogenital schistosomiasis, malnutrition, anaemia, haematuria, microcytosis and thrombocytopenia was prevalent in 24.4, 24.6, 25.9, 74.4, 12.2, 45.4 and 11.1% of SAC, respectively. A significant linear decline (P = 0.023) in prevalence of P. falciparum infection with the severity of stunting was observed. Factors that significantly influenced haematological parameters included haemoglobin: age, stunting and MP; haematocrit: age and MP; white blood cell count: age; red blood cell count; age and MP; lymphocyte counts: stunting; mean cell volume: age; mean cell haemoglobin: age and stunting; mean cell haemoglobin concentration: sex, stunting and red cell distribution width-coefficient of variation: sex, age and stunting. Conclusions Malnutrition, Plasmodium and S. haematobium infections are common while anaemia is a severe public health problem in Muyuka, Cameroon. The interaction between haematological parameters with malaria parasites as well as linear growth index was negative and other interactions indicate systemic inflammation. While findings provide contextual intervention targets to ensure the judicious use of the limited resources, there is need for regular monitoring and proper treatment to improve the health of the underserved population.

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