scholarly journals Long term follow up of spinal trabecular bone mineral density in women with non-steroid treated rheumatoid arthritis.

1994 ◽  
Vol 53 (2) ◽  
pp. 149-149 ◽  
Author(s):  
A M Cooper ◽  
M M O'Sullivan ◽  
D Clements ◽  
J E Compston ◽  
W D Evans ◽  
...  
1999 ◽  
Vol 31 (6) ◽  
pp. 2322-2323 ◽  
Author(s):  
A Moreno ◽  
J.V Torregrosa ◽  
F Pons ◽  
J.M Campistol ◽  
M.J Martı́nez de Osaba ◽  
...  

Author(s):  
Himika Chawla ◽  
Soma Saha ◽  
Devasenathipathy Kandaswamy ◽  
Raju Sharma ◽  
Vishnubhatla Sreenivas ◽  
...  

2003 ◽  
Vol 58 (5) ◽  
pp. 617-620 ◽  
Author(s):  
Esteban Jódar ◽  
María Pilar Ruiz Valdepeñas ◽  
Guillermo Martinez ◽  
Antonino Jara ◽  
Federico Hawkins

1998 ◽  
Vol 48 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Paul Van Kesteren ◽  
Paul Lips ◽  
Louis J. G. Gooren ◽  
Henk Asscheman ◽  
Jos Megens

1996 ◽  
Vol 6 (S1) ◽  
pp. 277-277
Author(s):  
P. J. M. van Kesteren ◽  
P. Lips ◽  
H. Asscheman ◽  
J. A. J. Megens ◽  
L. J. G. Gooren

2020 ◽  
Vol 11 ◽  
pp. 204062232098151
Author(s):  
Chung-Yuan Hsu ◽  
Jia-Feng Chen ◽  
Yu-Jih Su ◽  
Ying-Chou Chen ◽  
Han-Ming Lai ◽  
...  

Background: Rheumatoid arthritis (RA) is associated with poor bone mineral density (BMD). We designed the current study owing to the lack of long-term prospective studies regarding whether a high disease activity leads to increased bone loss. Methods: We have continually enrolled patients with RA. According to the average disease activity score in 28 joints based on the erythrocyte sedimentation rate (DAS28-ESR) during follow-up, the patients were classified into remission, low disease activity, and moderate or high disease activity groups. Patients were examined with dual-energy X-ray absorptiometry at baseline and after 3 years of follow-up. BMD changes were compared among the groups. Results: We have studied 477 patients. Overall BMD was significantly reduced from baseline to the 3-year follow-up ( p < 0.05). After stratifying according to the time-averaged DAS28-ESR levels and use of anti-osteoporosis treatment (AOT), the BMD values of the femur and spine significantly increased in patients in the remission group with AOT. The BMD changes of different DAS28-ESR patients were further compared using the generalized estimation equation model. For the patients on AOT, the negative change in femoral BMD values of the moderate or high activity group was significant when compared with the remission group with positive BMD changes (regression coefficient, –0.038; 95% confidence interval, –0.055 to –0.021). Conclusion: For RA patients, if remission is achieved, AOT can better improve BMD, especially in the femur. In addition, moderate or high disease activity will lead to significant bone loss; therefore, disease activity must be actively controlled.


2021 ◽  
pp. S61-S68
Author(s):  
P. Vaňuga ◽  
M. Kužma ◽  
D. Stojkovičová ◽  
J. Smaha ◽  
P. Jackuliak ◽  
...  

There are only few studies concerning about long-term effect of growth hormone (GH) replacement therapy on bone mineral density and bone microstructure. To assess effect of GH replacement therapy on bone mineral density (BMD) and trabecular bone score (TBS) in adult GH deficient (AGHD) subjects over period of 10 years. From 2005 to 2018, a prospective study of AGHD patients was conducted in national referral center for treatment of GHD. All patients received subcutaneous recombinant human GH in an IGF 1-normalizing regimen once a day. Lumbar spine (L-spine) and total hip (TH) BMD using Hologic densitometers were measured at baseline and every two years during treatment with rhGH. TBS was derived from L1-L4 DXA using iNsight® software (Medimaps, France) at each time point. Periods of measurement were baseline, year 2; 4; 6; 8 and 10. In total, 63 patients (38 males, 25 females, mean age 25.1±16 years) were included in the study. After 10 years of GH treatment, IGF-1 significantly increased (~35 %), with greatest increase at year 2. During 10-year follow-up, L-spine BMD increased approximately of 7 % (NS). TH BMD increase of 11 % during follow-up (p=0.0003). The greatest increment of BMD was achieved at year 6 on both sites, L-spine (+6 %) and TH BMD (+13 %) (p<0.05). There was no significant change of TBS during whole follow-up. In this study, sustaining positive effect of GH replacement therapy on bone density in subjects with adult GH deficiency over 10 years of follow-up was observed. The study did not show effect on TBS, as indirect measure of trabecular bone microarchitecture.


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