scholarly journals Signet-ring cell adenocarcinoma of unknown primary presenting with superior vena cava (SVC) syndrome: rare type of cancer

2019 ◽  
Vol 12 (12) ◽  
pp. e232269
Author(s):  
Ramon Bagaporo Larrazabal, Jr ◽  
Paula Victoria Catherine Cheng ◽  
Aileen David-Wang ◽  
Daryl Requiso
Keyword(s):  
Gastric Wall ◽  
Vena Cava ◽  
Lower Lobe ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Wall Thickening ◽  
Outpatient Basis ◽  
Signet Ring ◽  
Ring Cell ◽  
Work Up

A 53-year-old man presented with a 3-month history of progressive, non-productive cough followed by occasional swelling of the face and upper extremities. Physical examination on admission revealed prominent superficial vessels at the neck and upper extremity swelling. Bronchoscopy revealed the superior segment of the right lower lobe was narrow but without visible mass; cell block and biopsy done revealed signet-ring cell carcinoma with an immunohistochemistry pattern favouring the primary site of malignancy as either gastric or of the pancreaticobiliary tree. However, CT scan of the abdomen and pelvis with triple contrast revealed only slight gastric wall thickening; the pancreas was unremarkable. The patient underwent radiotherapy with noted improvement of symptoms. He was then discharged with plans for further work-up on an outpatient basis. This work highlights the importance of a comprehensive histopathological and immunohistochemical work-up which can help predict a site of origin to be able to provide the appropriate management.

Cancer Associated Microangiopathic Hemolytic Anemia: A Rare Paraneoplastic Syndrome

2021 ◽  
pp. 1-5
Author(s):  
Aravind Reddy Kuchkuntla ◽  
Keyword(s):  
Therapeutic Option ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Underlying Malignancy ◽  
Signet Ring ◽  
Adamts13 Deficiency ◽  
Ring Cell ◽  
Work Up ◽  
Significant Mortality

Microangiopathic hemolytic anemias (MAHA) are secondary to damage of RBCs because of endothelial vascular damage of blood vessels leading to hemolysis. MAHAs are characterized by negative coombs test and are associated with several etiologies that include can be either hereditary complement or ADAMTS13 deficiency or sepsis or malignancy. Cancer associated MAHA (CA-MAHA) is a rare and is seen in patients with advanced metastatic disease. CA-MAHA has significant mortality rate and chemotherapy is the only therapeutic option, however overall survival is poor. Here we, present a rare case of CA-MAHA secondary to metastatic signet ring cell carcinoma with an unknown primary. In patients, when the cause of progressive MAHA is unknown, the possibility of cancer associated MAHA must be considered and a comprehensive work up for an underlying malignancy must be done.

scholarly journals Signet Ring Cell Carcinoma of Unknown Primary Complicated with Pulmonary Tumor Thrombotic Microangiopathy and Krukenberg Tumor

2018 ◽  
Vol 11 (2) ◽  
pp. 412-417
Author(s):  
Masahide Tanaka ◽  
Koichiro Takahashi ◽  
Yuki Kurihara ◽  
Mihoko Yamamoto-Rikitake ◽  
Shinsuke Ogusu ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Krukenberg Tumor ◽  
Carcinoma Of Unknown Primary ◽  
Pulmonary Tumor ◽  
Signet Ring ◽  
Ring Cell

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare disease that shows hypoxia with severe pulmonary hypertension related to malignant tumor. Diagnosis is difficult due to rapid clinical progression and the need to demonstrate pathological findings from lung biopsy. A 64-year-old woman visited our hospital with hypoxia and pulmonary hypertension. Diffuse granular shadows in the centrilobular area and ground-glass shadows in both lungs and left ovarian tumor were found on radiological imaging. PTTM was suspected, but pulmonary artery blood aspiration by right cardiac catheter failed to detect cancer cells. We could not obtain lung or ovary biopsies because of hypoxia or pulmonary hypertension. The patient died due to respiratory failure. Signet ring cell carcinoma of unknown primary, PTTM, and Krukenberg tumor were diagnosed on autopsy. Since early diagnosis facilitates adequate treatment, physicians should not miss the opportunity for biopsy in cases of suspected PTTM.

Metastatic signet-ring cell melanoma in a patient with an unknown primary tumor

1992 ◽  
Vol 26 (5) ◽  
pp. 870-875 ◽  
Author(s):  
Fritjof Eckert ◽  
Branko Baričević ◽  
Michael Landthaler ◽  
Ulrico Schmid
Keyword(s):  
Primary Tumor ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Unknown Primary Tumor ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Testicular Signet-Ring Cell Metastasis from a Carcinoma of Unknown Primary Site: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Aristomenes Kollas ◽  
George Zarkavelis ◽  
Anna Goussia ◽  
Aikaterini Kafantari ◽  
Anna Batistatou ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Daily Practice ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Short Paper ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Ring Cell ◽  
Testicular Metastases

Signet-ring cell carcinoma is a highly malignant adenocarcinoma consisting of cells characterized as cytoplasmic vacuoles filled with mucin. The most common primary location of this type of cancer is the stomach, but it may also be found in other organs such as prostate, testis, bladder, ovaries, or colon. To date, metastatic signet-ring cell carcinoma of unknown primary (CUP) site to the testis is an extremely rare entity in daily practice. Reviewing the literature, we have been able to detect only three cases of testicular metastases from CUP, two with histological diagnosis of a signet-ring cell carcinoma and one with an adenocarcinoma. In this short paper, we report a case of a 56-year-old man who presented to our Department with testicular mass and ascites. Following a standard diagnostic approach no primary tumor could be identified. CUP was the final clinical diagnosis, histologically characterized as poorly differentiated adenocarcinoma with signet-ring cells involving the peritoneum and the testicular structures.

scholarly journals A Case of Signet Ring Cell Carcinoma of Unknown Primary Origin Accompanied by Swollen Cervical Lymph Nodes

Haigan ◽  
2013 ◽  
Vol 53 (3) ◽  
pp. 259-263 ◽  
Author(s):  
Kotaro Kajiwara ◽  
Chizuru Hamada ◽  
Mayuko Semba ◽  
Naohiko Hamaguchi ◽  
Takanori Kanematsu ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Cervical Lymph Nodes ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Primary Origin ◽  
Ring Cell ◽  
Unknown Primary Origin

scholarly journals Metastatic signet ring cell carcinoma of unknown primary source

2014 ◽  
Vol 2014 (feb17 1) ◽  
pp. bcr2013203407-bcr2013203407 ◽  
Author(s):  
D. O'Kane ◽  
K. Dean ◽  
R. Nightingale ◽  
S. Carlotto
Keyword(s):  
Cell Carcinoma ◽  
Primary Source ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Signet Ring Cell Carcinoma of Unknown Primary Origin Detected Incidentally by Lymph Node Purification for Thyroid Carcinoma

2018 ◽  
Vol 57 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Hideo Handa ◽  
Daisuke Gomi ◽  
Toshirou Fukushima ◽  
Takashi Kobayashi ◽  
Nodoka Sekiguchi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Primary Origin ◽  
Ring Cell ◽  
Unknown Primary Origin
Sign in / Sign up

Export Citation Format

Share Document