Rare case of Ureaplasma parvum septic arthritis in an immunocompetent patient

2020 ◽  
Vol 13 (9) ◽  
pp. e236396
Author(s):  
Abuzar Ali Asif ◽  
Moni Roy ◽  
Sharjeel Ahmad
Keyword(s):  
Septic Arthritis ◽  
Rare Case ◽  
Immunocompetent Patient ◽  
Next Generation ◽  
Ureaplasma Parvum ◽  
Urogenital Infections ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Diagnostic Modalities

Mycoplasmatacea family comprises two genera: Mycoplasma and Ureaplasma. Ureaplasma parvum (previously known as U. urealyticum biovar 1) commonly colonises the urogenital tract in humans. Although Ureaplasma species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to U. parvum identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of Ureaplasma septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.

scholarly journals The difference between native septic arthritis and prosthetic joint infections: A review of literature

2019 ◽  
Vol 27 (2) ◽  
pp. 230949901986046 ◽  
Author(s):  
Ramon Lucas Roerdink ◽  
Henricus Johannus Theodorus Antoniu Huijbregts ◽  
Antoine Willy Tonny van Lieshout ◽  
Martijn Dietvorst ◽  
Babette Corine van der Zwaard
Keyword(s):  
Septic Arthritis ◽  
Current Literature ◽  
Treatment Strategies ◽  
Review Of Literature ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
The Difference

Current literature occasionally considers septic arthritis in native joints and prosthetic joint infections as equal pathologies. However, significant differences can be identified. The aim of this review of literature is to describe these differences in definitions, pathology, diagnostic workups, treatment strategies, and prognosis.

Epidemiology, Management, and Outcomes of Large and Small Native Joint Septic Arthritis in Adults

2019 ◽  
Vol 70 (2) ◽  
pp. 271-279 ◽  
Author(s):  
Stephen McBride ◽  
Jessica Mowbray ◽  
William Caughey ◽  
Edbert Wong ◽  
Christopher Luey ◽  
...  
Keyword(s):  
Treatment Failure ◽  
Septic Arthritis ◽  
Surgical Procedures ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Total Incidence ◽  
Large Joint ◽  
Prosthetic Joint Infections ◽  
Small Joint ◽  
Antibiotic Duration

Abstract Background Native joint septic arthritis (NJSA) is poorly studied. We describe the epidemiology, treatment, and outcomes of large joint NJSA (LNJSA) and small joint NJSA (SNJSA) in adults at Middlemore Hospital, Auckland, New Zealand. Methods This was a coding-based retrospective study of patients ≥16 years old admitted between 2009 and 2014. Prosthetic joint infections were excluded. Results Five hundred forty-three NJSA episodes were included (302 LNJSA, 250 SNJSA). Only 40% had positive synovial fluid culture. Compared to SNJSA, LNJSA has higher incidence (13 vs 8/100 000 person-years [PY]), occurs in older, more comorbid patients, and is associated with greater rates of treatment failure (23% vs 12%) and mortality, despite longer antibiotic treatment. Total incidence is higher than previously reported (21/100 000 PY), with marked interethnic variation. Incidence rises with age (LNJSA only) and socioeconomic deprivation (LNJSA and SNJSA). Tobacco smokers and males are overrepresented. The most commonly involved joints were knee (21%) and hand interphalangeal (20%). Staphylococcus aureus was the most common pathogen (53%). Mean antibiotic duration was 25 days for SNJSA and 40 days for LNJSA, and the mean number of surgical procedures was 1.5 and 1.6, respectively. Treatment failure was independently associated with LNJSA, age, intra-articular nonarthroplasty prosthesis, and number of surgical procedures. Conclusions This is the largest contemporary series of adult NJSA. SNJSA has better outcomes than LNJSA and may be able to be safely treated with shorter antimicrobial courses. Incidence is high, with significant ethnic and socioeconomic variation. Microbiological NJSA case ascertainment underestimates case numbers as it frequently excludes SNJSA.

scholarly journals A Real Pain: Diagnostic Quandaries and Septic Arthritis

2017 ◽  
Vol 56 (2) ◽  
Author(s):  
Cristina Costales ◽  
Susan M. Butler-Wu
Keyword(s):  
Septic Arthritis ◽  
Laboratory Tests ◽  
Joint Infection ◽  
Rapid Diagnosis ◽  
Accurate Diagnosis ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
The Many ◽  
Future Utility

ABSTRACT Rapid diagnosis and treatment of an infected joint are paramount in preserving orthopedic function. Here, we present a brief review of the many challenges associated with the diagnosis of both septic arthritis and prosthetic joint infections. We also discuss the many laboratory tests currently available to aid in the accurate diagnosis of joint infection, as well as emerging diagnostics that may have future utility in the diagnosis of these challenging clinical entities.

scholarly journals Cutibacterium acnes Septic Arthritis of the Nonoperated Knee: A Case Report

2017 ◽  
Vol 03 (03) ◽  
pp. e107-e109 ◽  
Author(s):  
Kelechi Okoroha ◽  
Michael Gabbard ◽  
Jamal Fitts ◽  
Trevor Banka
Keyword(s):  
Septic Arthritis ◽  
Clinical Judgment ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Cutibacterium Acnes ◽  
Antibiotic Management ◽  
Uncommon Case ◽  
Selection For ◽  
Septic Knee Arthritis

Abstract Cutibacterium (Propionibacterium) acnes, a gram-positive bacillus with low pathogenicity, is an uncommon but known cause of prosthetic joint infections, particularly related to shoulder surgery. C. acnes, however, is an extremely rare pathogen in the nonoperated knee joint. This report details an uncommon case of C. acnes septic knee arthritis after multiple intra-articular steroid injections in a 56-year-old male patient. After an indolent presentation and late diagnosis, the patient underwent surgical debridement with IV antibiotic management. This case illustrates that intra-articular corticosteroid injections for the management of osteoarthritis are not without risk. Literature supporting their use remains limited and clinicians should use proficient clinical judgment for appropriate patient selection for these injections. Vigilance following injections or aspirations of the knee should be maintained to identify the indolent clinical presentation of C. acnes septic arthritis.

scholarly journals Predictive Antibiotic Susceptibility Testing by Next-Generation Sequencing for Periprosthetic Joint Infections: Potential and Limitations

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 910
Author(s):  
Lukas Lüftinger ◽  
Ines Ferreira ◽  
Bernhard J. H. Frank ◽  
Stephan Beisken ◽  
Johannes Weinberger ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Antibiotic Susceptibility ◽  
Susceptibility Testing ◽  
Multidrug Resistant ◽  
Antibiotic Susceptibility Testing ◽  
Next Generation ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Generation Sequencing

Joint replacement surgeries are one of the most frequent medical interventions globally. Infections of prosthetic joints are a major health challenge and typically require prolonged or even indefinite antibiotic treatment. As multidrug-resistant pathogens continue to rise globally, novel diagnostics are critical to ensure appropriate treatment and help with prosthetic joint infections (PJI) management. To this end, recent studies have shown the potential of molecular methods such as next-generation sequencing to complement established phenotypic, culture-based methods. Together with advanced bioinformatics approaches, next-generation sequencing can provide comprehensive information on pathogen identity as well as antimicrobial susceptibility, potentially enabling rapid diagnosis and targeted therapy of PJIs. In this review, we summarize current developments in next generation sequencing based predictive antibiotic susceptibility testing and discuss potential and limitations for common PJI pathogens.

Septic Arthritis and Prosthetic Joint Infections in Older Adults

2017 ◽  
Vol 31 (4) ◽  
pp. 715-729 ◽  
Author(s):  
Rajeshwari Nair ◽  
Marin L. Schweizer ◽  
Namrata Singh
Keyword(s):  
Older Adults ◽  
Septic Arthritis ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections

Bone and joint infections

2016 ◽  
Author(s):  
M. Estée Török ◽  
Fiona J. Cooke ◽  
Ed Moran
Keyword(s):  
Diabetes Mellitus ◽  
Septic Arthritis ◽  
Diabetic Foot ◽  
Bone Destruction ◽  
Joint Space ◽  
Joint Infections ◽  
Diabetic Foot Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Knee Replacements

This chapter provides an overview of inflammations of the joint space and bones, such as arthritis and bursitis, including osteomyelitis and bone destruction and formation of sequestra. The chapter also includes prosthetic joint infections such as hip and knee replacements. It also describes diabetic foot infections, defined as any inframalleolar infection in a patient with diabetes mellitus. Infections include paronychia, cellulitis, myositis, abscesses, necrotizing fasciitis, septic arthritis, tendonitis, and osteomyelitis.

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