Pyogenic granuloma-like Kaposi sarcoma presenting in an HIV-negative man who has sex with men

2020 ◽  
Vol 13 (11) ◽  
pp. e237420
Author(s):  
Bernard Ho ◽  
Giulia Rinaldi ◽  
Imran Khan ◽  
Susanna Szakacs
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Pyogenic Granuloma ◽  
Herpesvirus 8 ◽  
Dermatology Clinic ◽  
Spindle Cell Proliferation ◽  
Sex With Men ◽  
The Right ◽  
Intermittent Bleeding ◽  
Hiv Negative

A 36-year-old immunocompetent man who have sex with men first presented to the plastics team with an ulcerating lesion on his left first toe. The lesion was suggestive of pyogenic granuloma (PG) clinically and histologically. Two years later, the same patient presented to the dermatology clinic with a new erythematous lesion with intermittent bleeding on the left second toe. Clinically, this lesion was suggestive of another PG. However, the histology of the skin curettage revealed part of a PG merging with an atypical spindle cell proliferation with characteristic ‘sieve-like’ appearance in keeping with Kaposi sarcoma. This was confirmed with human herpesvirus-8 immunohistochemistry staining. PG-like Kaposi sarcoma is an uncommon variant of Kaposi sarcoma. Often not considered clinically or histologically, a deep skin biopsy is essential to establish the right diagnosis. Our case highlights the need to consider Kaposi sarcoma as a differential diagnosis in all patients, including HIV-negative individuals, presenting with PG-like lesions.

scholarly journals Pyogenic granuloma-like Kaposi sarcoma: Case report and review of literature

2020 ◽  
Vol 5 (2) ◽  
pp. 66
Author(s):  
Mardiana Abdul Aziz ◽  
Effat Omar
Keyword(s):  
Histopathological Examination ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Asian Population ◽  
Pyogenic Granuloma ◽  
Vascular Lesion ◽  
Hiv Positive ◽  
Herpesvirus 8 ◽  
Positive Individual ◽  
Spindle Cell Proliferation

Pyogenic granuloma-like Kaposi sarcoma (PGLKS) is an uncommon variant of Kaposi sarcoma (KS), which mimics benign pyogenic granuloma both clinically and histologically. We report a case of PGLKS of the toe occurring in a HIV-positive individual. It presented as a 2cm skin swelling of 2 weeks’ duration which was clinically felt to be a pyogenic granuloma. Histopathological examination revealed a polypoid atypical vascular lesion with overlying peripheral epidermal collarette. Spindle cell proliferation typically seen in KS was also identified, which was positive for human herpesvirus 8 (HHV8) by immunohistochemistry, confirming the diagnosis of PGLKS. Upon review of the literature, our case is the 29th case of PGLKS reported to date, and only the sixth in Asian population. Particular attention to histomorphology, and demonstration of HHV8 in lesional tissue will aid accurate diagnosis of this rare entity.

scholarly journals Maxillary Sinus Kaposi Sarcoma: Case Report in an HIV-Negative Patient with Thymoma

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Bernardo Carvalho Araújo ◽  
Sara Viana Baptista ◽  
Luís Mascarenhas ◽  
Ezequiel Barros
Keyword(s):  
Case Report ◽  
Maxillary Sinus ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Herpesvirus 8 ◽  
The Right ◽  
Clinical Records ◽  
Careful Investigation ◽  
Hiv Negative

Introduction. Kaposi sarcoma is an angioproliferative disorder that requires infection with human herpesvirus 8 (HHV-8) for its development. The majority of cases are associated with HIV infection or other immunocompromising conditions. Thymomas are occasionally associated to cytopenia, which may alter the patients’ immune responses. Methods. Case report using clinical records. Results. Case report of a 46-year-old male patient diagnosed with thymoma and myasthenia gravis. The patient was referred to an otolaryngology consultation with complaints of facial pain in the right malar region, interpreted as an acute sinusitis. Following examination, an expansive maxillary sinus mass was found, and endoscopic surgery was undertaken. After careful investigation, it was diagnosed as a Kaposi sarcoma. Conclusions. It is thought to be the first described case of a maxillary sinus Kaposi sarcoma in an HIV-negative patient. Thus, this entity has to be considered in the differential diagnosis of sinus masses, even in non-HIV patients.

scholarly journals Atypical Manifestations in Classic Kaposi Sarcoma: Case Series of Two Patients HIV - Negative

2019 ◽  
Vol 7 (6) ◽  
pp. 1021-1024 ◽  
Author(s):  
Tiziana Peduto ◽  
Francesco Cillo ◽  
Paola Nappa ◽  
Mario Delfino ◽  
Gabriella Fabbrocini ◽  
...  
Keyword(s):  
Case Series ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Skin Lesions ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Atypical Manifestations ◽  
Classic Kaposi Sarcoma ◽  
Prompt Diagnosis ◽  
Hiv Negative

BACKGROUND: Kaposi's sarcoma (KS) is a tumour of endothelial, blood and lymphatic cells, caused by an infection with human herpesvirus-8 (HHV-8). The skin lesions of KS, especially of the classical or Mediterranean variant (CKS), are represented by red-purple macules, plaques and nodules, localised mainly on the extremities. CASE REPORT: This case series intend to describe multifocal atypical kaposian manifestations in two HIV negative subjects, affected by CKS, treated with successful chemotherapy. CONCLUSIONS: Although atypical manifestations are extremely rare events, we suggest an accurate, objective examination because a prompt diagnosis can lead to a vital intervention in the patient's health and sometimes to the identification of the disease itself.

A Kaposi-like Variant of Splenic Angiosarcoma Lacking Association With Human Herpesvirus 8

2002 ◽  
Vol 126 (2) ◽  
pp. 191-194
Author(s):  
Tetuo Mikami ◽  
Makoto Saegusa ◽  
Fumiyuki Akino ◽  
Daisuke Machida ◽  
Keiichi Iwabuchi ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Polymerase Chain Reaction Analysis ◽  
Human Herpesvirus 8 ◽  
Diagnostic Feature ◽  
Proliferating Cells ◽  
Herpesvirus 8 ◽  
Metastatic Lesions ◽  
Spindle Cell Proliferation ◽  
Splenic Angiosarcoma

Abstract We report the case of a Kaposi-like variant of splenic angiosarcoma in a 28-year-old woman. The tumor featured a Kaposi sarcoma–like spindle cell proliferation with slit formation and markedly dilated spongelike vascular channels filled with erythrocytes. Thirteen months following the initial splenectomy, metastatic lesions were found in the patient's liver and bone marrow. The proliferating cells were positive for factor VIII–associated antigen and CD34. The human herpesvirus 8 genome, which is regarded as a diagnostic feature of Kaposi sarcoma, was not detected by polymerase chain reaction analysis. Although the histologic findings were similar, this Kaposi-like variant of splenic angiosarcoma must be considered distinct from Kaposi sarcoma.

HIV Infection and Human Herpesvirus-8 Oral Shedding Among Men Who Have Sex with Men

2004 ◽  
Vol 35 (3) ◽  
pp. 233-238 ◽  
Author(s):  
Corey Casper ◽  
Mary Redman ◽  
Meei-Li Huang ◽  
John Pauk ◽  
Thomas M. Lampinen ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Sex With Men
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