scholarly journals Pyogenic granuloma-like Kaposi sarcoma: Case report and review of literature

2020 ◽  
Vol 5 (2) ◽  
pp. 66
Author(s):  
Mardiana Abdul Aziz ◽  
Effat Omar
Keyword(s):  
Histopathological Examination ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Asian Population ◽  
Pyogenic Granuloma ◽  
Vascular Lesion ◽  
Hiv Positive ◽  
Herpesvirus 8 ◽  
Positive Individual ◽  
Spindle Cell Proliferation

Pyogenic granuloma-like Kaposi sarcoma (PGLKS) is an uncommon variant of Kaposi sarcoma (KS), which mimics benign pyogenic granuloma both clinically and histologically. We report a case of PGLKS of the toe occurring in a HIV-positive individual. It presented as a 2cm skin swelling of 2 weeks’ duration which was clinically felt to be a pyogenic granuloma. Histopathological examination revealed a polypoid atypical vascular lesion with overlying peripheral epidermal collarette. Spindle cell proliferation typically seen in KS was also identified, which was positive for human herpesvirus 8 (HHV8) by immunohistochemistry, confirming the diagnosis of PGLKS. Upon review of the literature, our case is the 29th case of PGLKS reported to date, and only the sixth in Asian population. Particular attention to histomorphology, and demonstration of HHV8 in lesional tissue will aid accurate diagnosis of this rare entity.

Pyogenic granuloma-like Kaposi sarcoma presenting in an HIV-negative man who has sex with men

2020 ◽  
Vol 13 (11) ◽  
pp. e237420
Author(s):  
Bernard Ho ◽  
Giulia Rinaldi ◽  
Imran Khan ◽  
Susanna Szakacs
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Pyogenic Granuloma ◽  
Herpesvirus 8 ◽  
Dermatology Clinic ◽  
Spindle Cell Proliferation ◽  
Sex With Men ◽  
The Right ◽  
Intermittent Bleeding ◽  
Hiv Negative

A 36-year-old immunocompetent man who have sex with men first presented to the plastics team with an ulcerating lesion on his left first toe. The lesion was suggestive of pyogenic granuloma (PG) clinically and histologically. Two years later, the same patient presented to the dermatology clinic with a new erythematous lesion with intermittent bleeding on the left second toe. Clinically, this lesion was suggestive of another PG. However, the histology of the skin curettage revealed part of a PG merging with an atypical spindle cell proliferation with characteristic ‘sieve-like’ appearance in keeping with Kaposi sarcoma. This was confirmed with human herpesvirus-8 immunohistochemistry staining. PG-like Kaposi sarcoma is an uncommon variant of Kaposi sarcoma. Often not considered clinically or histologically, a deep skin biopsy is essential to establish the right diagnosis. Our case highlights the need to consider Kaposi sarcoma as a differential diagnosis in all patients, including HIV-negative individuals, presenting with PG-like lesions.

EBV+ HHV-8+ Multicentric Castleman Disease With Plasmablastic Aggregates in an HIV+ Man: An Evolving Clinicopathologic Entity

2017 ◽  
Vol 26 (4) ◽  
pp. 338-341 ◽  
Author(s):  
Aditya Shivane ◽  
Amy Pearce ◽  
Nadia Khatib ◽  
Mark E. F. Smith
Keyword(s):  
Human Herpesvirus ◽  
Cervical Lymphadenopathy ◽  
Castleman Disease ◽  
Hiv Positive ◽  
Herpesvirus 8 ◽  
Multicentric Castleman Disease ◽  
Barr Virus ◽  
Positive Individual ◽  
Epstein Barr

We report a case of EBV+ and HHV-8+ multicentric Castleman disease with plasmablastic aggregates in an HIV-positive individual. A 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be HIV positive. Investigations showed cervical lymphadenopathy and splenomegaly. He was treated for HIV and his symptoms resolved. His symptoms recurred in January 2016, and a provisional diagnosis of multicentric Castleman disease was entertained. The HHV-8 (human herpesvirus-8) and EBV (Epstein-Barr virus) viral load was elevated. A left supraclavicular lymph node core biopsy was performed, which showed features of multicentric Castleman disease with plasmablastic aggregates that are EBV (EBER) and HHV-8 positive. He responded well to rituximab treatment and remains well with no symptoms at recent follow-up.

scholarly journals Kaposi sarcoma in HIV-positive children: what are the symptoms and pathophysiology?

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
M Corrêa ◽  
J W Barretto ◽  
L Gusso ◽  
O S Erdmann ◽  
R S Vaz
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Hiv Infections ◽  
Skin Lesions ◽  
Western World ◽  
Hiv Positive ◽  
Herpesvirus 8 ◽  
Pubmed Database ◽  
Immunodeficiency Virus ◽  
Predicting Factor

Abstract Background Introduction: Kaposi Sarcoma (KS) is a tumour caused by human herpesvirus 8 (HHV-8). It is more prevalent in Oriental Africa when compared to countries in the western world, and it is more aggressive in children, with a death rate close to 60%. Aims: clarify the symptoms and pathophysiology of the paediatric KS associated with human immunodeficiency virus (HIV), given the poor scientific production on the topic, and the fact that the knowledge of this disease on children is only an extrapolation of what is known in the adult. Methods Materials and methods: integrative review based on articles found in PubMed database, using the MeSH-indexed descriptors: ‘Children’ AND ‘Kaposi sarcoma’ AND ‘HIV infections’. Results Results: the seven selected studies show that, in HIV-positive children with KS, the prevalent symptoms are: skin lesions in multiple or unique sites, either isolated or associated with other lesions, such as oral and visceral, with the possibility of gastrointestinal bleeding, which could be deadly; lymphadenopathy in axillary, inguinal and cervical regions; respiratory symptoms; and anasarca. As for the pathophysiology, the most common occurrences are: cytopenia (anaemia and thrombocytopenia), both varying from moderate to severe; increased levels of CD4+ lymphocytes, which could act as predicting factor for lymphadenopathy; immunosuppression, a possible indicator for death; and increase in interleukin- 6 (IL-6) and IL-10 levels. Conclusions Conclusions: KS, caused by HHV-8, most prevalent in Africa, tends to be more aggressive in children, with main symptoms including lymphadenopathy and skin lesions, and main pathophysiological aspects including cytopenia and increase in IL-6 and IL-10.

Primary nasal Kaposi Sarcoma in well-controlled HIV-positive patient with normal CD4 count associated with long-term nasal steroid use

2021 ◽  
Vol 32 (6) ◽  
pp. 582-584
Author(s):  
Kyaw Zin Htet ◽  
Michael Waul ◽  
Howard Edelstein ◽  
Stanley Mui ◽  
Sarah Cherny ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Cd4 Count ◽  
Hiv Positive ◽  
Steroid Use ◽  
Herpesvirus 8 ◽  
Cd4 Counts ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Kaposi sarcoma (KS) is an angioproliferative disease that is caused by human herpesvirus 8. The epidemic form of KS is associated with acquired immunodeficiency syndrome (AIDS) and is common in HIV-positive patients with CD4 counts less than 200 cells/mm. We present the case of a 63-year-old man with well-controlled HIV and normal CD4 count developing atypical nasal KS associated with intranasal steroid use.

A Kaposi-like Variant of Splenic Angiosarcoma Lacking Association With Human Herpesvirus 8

2002 ◽  
Vol 126 (2) ◽  
pp. 191-194
Author(s):  
Tetuo Mikami ◽  
Makoto Saegusa ◽  
Fumiyuki Akino ◽  
Daisuke Machida ◽  
Keiichi Iwabuchi ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Polymerase Chain Reaction Analysis ◽  
Human Herpesvirus 8 ◽  
Diagnostic Feature ◽  
Proliferating Cells ◽  
Herpesvirus 8 ◽  
Metastatic Lesions ◽  
Spindle Cell Proliferation ◽  
Splenic Angiosarcoma

Abstract We report the case of a Kaposi-like variant of splenic angiosarcoma in a 28-year-old woman. The tumor featured a Kaposi sarcoma–like spindle cell proliferation with slit formation and markedly dilated spongelike vascular channels filled with erythrocytes. Thirteen months following the initial splenectomy, metastatic lesions were found in the patient's liver and bone marrow. The proliferating cells were positive for factor VIII–associated antigen and CD34. The human herpesvirus 8 genome, which is regarded as a diagnostic feature of Kaposi sarcoma, was not detected by polymerase chain reaction analysis. Although the histologic findings were similar, this Kaposi-like variant of splenic angiosarcoma must be considered distinct from Kaposi sarcoma.

Changes in the Immune Responses Against Human Herpesvirus-8 in the Disease Course of Posttransplant Kaposi Sarcoma

2008 ◽  
Vol 86 (5) ◽  
pp. 738-744 ◽  
Author(s):  
Patrizia Barozzi ◽  
Chiara Bonini ◽  
Leonardo Potenza ◽  
Michele Masetti ◽  
Gianni Cappelli ◽  
...  
Keyword(s):  
Immune Responses ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Disease Course ◽  
Herpesvirus 8

Presence of Human Herpesvirus 8 DNA Sequences in Renal Transplantation-Associated Pleural Kaposi Sarcoma

1999 ◽  
Vol 123 (12) ◽  
pp. 1269-1273
Author(s):  
J. Javier Gómez-Román ◽  
J. Gonzalo Ocejo-Vinyals ◽  
Pablo Sánchez-Velasco ◽  
Francisco Leyva-Cobián ◽  
J. Fernando Val-Bernal
Keyword(s):  
Kidney Transplantation ◽  
Pleural Effusion ◽  
Dna Sequences ◽  
Blot Hybridization ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Southern Blot Hybridization ◽  
Pulmonary Involvement ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8

Abstract Objective.—To describe one case of symptomatic skin and pleural Kaposi sarcoma (KS) associated with kidney transplantation. Diagnosis was supported by morphologic study and human herpesvirus 8 (HHV-8) detection in both tissues. Pulmonary involvement was not present. Design.—The presence of HHV-8 DNA sequences was proved using polymerase chain reaction (PCR), Southern blot hybridization, and in situ hybridization. Setting.—Human herpesvirus 8 is found in most KS from patients with and without the acquired immunodeficiency syndrome. Clinically significant pulmonary infiltration by KS is diagnosed uncommonly antemortem, and pleural disease is exceptional. Patient.—A 49-year-old man who had renal transplant with immunosuppressive therapy (tacrolimus and prednisone) and developed a cutaneous KS. A pleural effusion appeared without pulmonary involvement. Both lesions disappeared when immunosuppressive drugs were suspended. Later, the pleural effusion and the cutaneous lesions reappeared. Pleural biopsy specimens showed KS infiltration. Outcome.—The patient refused treatment and was lost to follow-up. Results.—The skin and pleural biopsies showed a proliferation of spindle-shaped cells positive for CD34. The HHV-8 sequences were detected by nested PCR. No amplification was detected in uninvolved skin from the patient or in peripheral blood mononuclear cells from 10 healthy individuals used as controls. The Southern blot hybridization confirmed these results. Conclusions.—To our knowledge, this is the first report of HHV-8 in symptomatic pleural KS, which was probably associated with immunosuppression after kidney transplantation. The demonstration of HHV-8 DNA in biopsy material in the appropriate cells could be diagnostic when the morphologic setting is consistent with KS.

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