Delayed-onset unilateral Vogt-Koyanagi-Harada syndrome: a multimodal imaging appraisal

2021 ◽  
Vol 14 (2) ◽  
pp. e238623
Author(s):  
Saurabh Verma ◽  
Himani Thakur ◽  
Shorya Vardhan Azad ◽  
Vinod Kumar
Keyword(s):  
Multimodal Imaging ◽  
Intravitreal Bevacizumab ◽  
Choroidal Neovascularisation ◽  
Enhanced Depth Imaging ◽  
Depth Imaging ◽  
Delayed Onset ◽  
First Case ◽  
Imaging Optical Coherence Tomography ◽  
The Right ◽  
Active Inflammation

A 38-year-old woman who had previously been diagnosed and treated for unilateral Vogt-Koyanagi-Harada syndrome (VKH) and had undergone multiple intravitreal bevacizumab injections to manage inflammatory choroidal neovascularisation in her right eye, presented 2 years later with visual complains in left eye. Clinical examination, fluorescein angiography, indocyanine green angiography (ICGA) and enhanced depth imaging optical coherence tomography (EDI-OCT) assisted evaluation confirmed active inflammation of left eye along with absence of any inflammation in the right eye. Unilateral active inflammation can be seen in the setting of VKH. To our best knowledge, ours is the first case of VKH in which unilateral active inflammation has been proven based on ICGA and EDI OCT analysis.

scholarly journals Multimodal imaging in choroidal metastasis

2020 ◽  
Author(s):  
Gilda Cennamo ◽  
Daniela Montorio ◽  
Marianna Carosielli ◽  
Mario R. Romano ◽  
Giovanni Cennamo
Keyword(s):  
Multimodal Imaging ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Subretinal Fluid ◽  
Enhanced Depth Imaging ◽  
Choroidal Metastasis ◽  
Depth Imaging ◽  
Lipofuscin Pigment ◽  
Imaging Optical Coherence Tomography ◽  
Intraocular Tumours

Background: Choroidal metastasis represent the most common malignant intraocular tumours. Objectives: To detect the structural and vascular features of choroidal metastasis by multimodal imaging. Methods: Sixteen eyes of 16 patients with choroidal metastasis were enrolled in this prospective study. The multimodal imaging was performed in all patients: fluorescein angiography, indocyanine green angiography, enhanced depth imaging optical coherence tomography (EDI-OCT), OCT angiography (OCTA) and ultrasonography. Results: The choroidal metastasis were located in the macula region in 9 eyes (57%) and in the extramacular region in 7 eyes (43%). EDI-OCT showed a mean thickness of 950 ± 246 µm, a smooth anterior tumour surface in 5 eyes (31%) and a lumpy bumpy appearance in 11 eyes (69%). The most frequent EDI-OCT features were represented by choriocapillaris thinning (100%), shaggy photoreceptors (82%), subretinal fluid with speckles (69%), subretinal lipofuscin pigment (6%), absence of drusen (100%), optical shadowing (94%), low internal optical reflectivity (75%) and retinal pigment epithelium alterations (43%). OCTA revealed an absence of intratumoral vascular network in all cases.

scholarly journals Fundoscopic Changes in Maroteaux-Lamy Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Augusto Magalhães ◽  
Jorge Meira ◽  
Ana Maria Cunha ◽  
Raul Jorge Moreira ◽  
Elisa Leão-Teles ◽  
...  
Keyword(s):  
Clinical Case ◽  
Survival Rates ◽  
Enhanced Depth Imaging ◽  
Depth Imaging ◽  
Poor Vision ◽  
Mps Vi ◽  
First Case ◽  
Imaging Optical Coherence Tomography

Purpose. To describe a clinical case of mucopolysaccharidosis type VI (MPS VI), or Maroteaux-Lamy syndrome, with fundoscopic alterations that may correspond to scleral deposits of glycosaminoglycans. Materials and Methods. Clinical case report. Results. A 16-year-old girl with MPS VI was examined at the Ophthalmology Department for poor vision due to opacified corneas. Treatment consisted of bilateral penetrating keratoplasty. Retinographies and enhanced depth imaging optical coherence tomography (EDI-OCT) were performed after surgery, suggesting the presence of scleral glycosaminoglycan deposits. The patient evolved with stable corneal and fundoscopic findings. Conclusions. To our knowledge, this is the first case of MPS VI described in vivo with suspected deposits of glycosaminoglycans in the sclera. Fundoscopic alterations are not usually included in the ocular pathological spectrum of MPS VI. However, with improved control of systemic comorbidities, survival rates of these patients have increased, which in turn has made it possible to observe other changes besides the ones that were classically described. Despite being particularly challenging to manage, efforts should be made to maximizing the visual acuity of these patients, in order to provide them the best possible quality of life.

scholarly journals Shaggy Photoreceptors with Subfoveal Fluid Associated with a Distant Choroidal Melanoma

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Ann Q. Tran ◽  
James A. Eadie ◽  
Michael M. Altaweel
Keyword(s):  
Choroidal Melanoma ◽  
Subretinal Fluid ◽  
Intravitreal Bevacizumab ◽  
Enhanced Depth Imaging ◽  
Global Changes ◽  
Depth Imaging ◽  
Before And After ◽  
Choroidal Melanomas ◽  
Imaging Optical Coherence Tomography ◽  
Subfoveal Fluid

Purpose. To describe the enhanced depth imaging optical coherence tomography (EDI-OCT) findings in a patient with an extra macula choroidal melanoma before and after treatment.Methods. Observational case report.Results. A 45 year-old Caucasian male patient was referred to retina clinic for management of choroidal melanoma. Examination revealed a nasal choroidal melanoma while EDI-OCT illustrated subfoveal fluid pocket with elongated shaggy photoreceptors distant and separate from the tumor. The patient was treated with plaque brachytherapy and intravitreal bevacizumab. One week after plaque removal, there was a dramatic reduction in the shaggy photoreceptors.Conclusion. Choroidal melanomas have effects that are not localized to the area of the tumor. This loculated pocket of subretinal fluid and coinciding changes to photoreceptor morphology may be related to global changes in choroidal function or release of tumor related cytokines.

scholarly journals In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180128 ◽  
Author(s):  
Tiago S. Prata ◽  
Flavio S. Lopes ◽  
Vitor G. Prado ◽  
Izabela Almeida ◽  
Igor Matsubara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Depth Imaging ◽  
In Vivo Analysis ◽  
Imaging Optical Coherence Tomography

CHOROIDAL LYMPHOMA SHOWS CALM, RIPPLED, OR UNDULATING TOPOGRAPHY ON ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY IN 14 EYES

Retina ◽  
2014 ◽  
Vol 34 (7) ◽  
pp. 1347-1353 ◽  
Author(s):  
Carol L. Shields ◽  
Sruthi Arepalli ◽  
Marco Pellegrini ◽  
Arman Mashayekhi ◽  
Jerry A. Shields
Keyword(s):  
Optical Coherence Tomography ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Depth Imaging ◽  
Imaging Optical Coherence Tomography

scholarly journals Choroidal thickness in eyes with different degrees of myopia

2013 ◽  
Vol 6 (4) ◽  
pp. 34-38 ◽  
Author(s):  
Yuriy Sergeyevich Astakhov ◽  
Svetlana Georgiyevna Belekhova
Keyword(s):  
Optical Coherence Tomography ◽  
Negative Correlation ◽  
Choroidal Thickness ◽  
Healthy People ◽  
Enhanced Depth Imaging ◽  
Control Group ◽  
Depth Imaging ◽  
Subfoveal Choroidal Thickness ◽  
Imaging Optical Coherence Tomography ◽  
Spectralis Oct

66 healthy people (124 eyes) with different degrees of myopia and emmetropia were examined using enhanced depth imaging optical coherence tomography (EDI-OCT) using the “Spectralis OCT”. It was found that the choroid in subjects with medium and high degrees of myopia was significantly thinner than that in the control group. In the study, a negative correlation was found between the subfoveal choroidal thickness and the degree of myopia (r = -0.75, p < 0.0001). It was also found that the subfoveal choroidal thickness decreased for each diopter of myopia by approximately 18.03 μm.

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