Diffuse alveolar haemorrhage in the setting of eosinophilic pneumonia

2021 ◽  
Vol 14 (4) ◽  
pp. e241672
Author(s):  
Adam T Ladzinski ◽  
Aditya Mehta ◽  
Brian J Dykstra ◽  
Sarah M Sharghi
Keyword(s):  
Weight Loss ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Eosinophilic Pneumonia ◽  
Alveolar Haemorrhage ◽  
Diffuse Alveolar Haemorrhage ◽  
Open Lung

A 65-year-old woman who presented with a constellation of symptoms, including cough with haemoptysis, fever, chills and hypoxia along with weight loss, was found to have diffuse alveolar haemorrhage. After a myriad of investigations returned normal, an open lung biopsy was performed, which revealed the diagnosis to be subacute eosinophilic pneumonia. This is one of its kind of rare presentations where eosinophilic pneumonia presents as diffuse alveolar haemorrhage and has been reported only five times prior to this.

scholarly journals Leptospirosis: An Unusual Cause of ARDS

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Marc Clavel ◽  
Gwenaelle Lhéritier ◽  
Nicolas Weinbreck ◽  
Antoine Guerlin ◽  
Anthony Dugard ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Lung Biopsy ◽  
Distress Syndrome ◽  
Multiple Organ ◽  
Open Lung Biopsy ◽  
Alveolar Haemorrhage ◽  
Massive Hemoptysis ◽  
Open Lung ◽  
Wild Rat ◽  
Severe Leptospirosis

Severe leptospirosis usually associates shock, jaundice, renal failure, and thrombocytopenia. Massive hemoptysis due to diffuse alveolar haemorrhage may rarely occur leading to an acute respiratory failure and multiple organ failure. We present the case of an acute respiratory distress syndrome caused by a severe leptospirosis. The severity of the respiratory failure contrasted with the absence of significant liver or renal dysfunction. Bedside open lung biopsy was only consistent with a postinfectious BOOP. The diagnosis was retrospective when the niece of the patient presented with similar inaugural symptoms ten days later after being scratched by a wild rat which was considered by our patient as a pet.

Open lung biopsy in patients on mechanical ventilation with suspected diffuse lung disease

2009 ◽  
Vol 15 (4) ◽  
pp. 597-611
Author(s):  
Natália Melo ◽  
Sandra Figueiredo ◽  
António Morais ◽  
Conceição Souto Moura ◽  
Paulo Pinho ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Diffuse Lung Disease ◽  
Open Lung ◽  
Diffuse Lung

Diagnostic Open Lung Biopsy in the Critically Ill Child

PEDIATRICS ◽  
1973 ◽  
Vol 52 (4) ◽  
pp. 605-608
Author(s):  
Stacy A. Roback ◽  
William H. Weintraub ◽  
Mark Nesbit ◽  
Panayiotis K. Spanos ◽  
Barbara Burke ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Critically Ill ◽  
Lung Tissue ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
University Of Minnesota ◽  
Biopsy Technique ◽  
Open Lung ◽  
Critically Ill Child ◽  
The University

Forty-six open biopsies in 40 acutely ill children with rapidly decreasing pulmonary reserve were performed at the University of Minnesota Hospitals between January 1, 1970, and January 1, 1972. Tissue obtained was adequate in all patients and no serious complications ensued. Information obtained resulted in the change in treatment in 30 patients. This procedure is recommended over closed biopsy when the magnitude of the patient's illness and degree of pulmonary function do not allow acceptance of the risks known to occur with a closed biopsy technique and when histologic examination of lung tissue is required.

Open lung biopsy in patients with acute leukemia

1985 ◽  
Vol 78 (4) ◽  
pp. 609-616 ◽  
Author(s):  
Robert E. McCabe ◽  
Robert G. Brooks ◽  
James B.D. Mark ◽  
Jack S. Remington
Keyword(s):  
Acute Leukemia ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Open Lung

scholarly journals Open Lung Biopsy for Diffuse Pulmonary Lesions

BMJ ◽  
1960 ◽  
Vol 1 (5165) ◽  
pp. 17-21 ◽  
Author(s):  
L. J. Grant ◽  
S. A. Trivedi
Keyword(s):  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Pulmonary Lesions ◽  
Open Lung

Pulmonary Fibrosis Induced by Cyclophosphamide

2001 ◽  
Vol 35 (7-8) ◽  
pp. 894-897 ◽  
Author(s):  
Angel Segura ◽  
Ana Yuste ◽  
Ana Cercos ◽  
Pedro López-Tendero ◽  
Regina Gironés ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pulmonary Fibrosis ◽  
Lung Biopsy ◽  
Pulmonary Function Tests ◽  
Diagnostic Technique ◽  
Open Lung Biopsy ◽  
Pulmonary Insufficiency ◽  
Open Lung ◽  
Case Summary ◽  
High Doses

OBJECTIVE: To report a case of pulmonary fibrosis resulting from use of cyclophosphamide as chemotherapy to treat a patient with breast cancer. CASE SUMMARY: We describe the case of a 52-year-old woman with breast cancer who developed pulmonary fibrosis after four cycles of chemotherapy that included cyclophosphamide. Pulmonary function tests revealed the presence of a severe ventilatory restriction. The open lung biopsy revealed pulmonary fibrosis with vascular sclerosis and signs of pulmonary hypertension. DISCUSSION: Cyclophosphamide is an alkylating agent that has been associated with interstitial pneumonia and pulmonary fibrosis. The frequency of these unwanted effects is '1%. The clinical picture consists of the progressive appearance of dyspnea and a nonproductive cough that progresses to severe pulmonary insufficiency. The risk factors described for these complications have been the use of chemotherapy regimens that include other drugs with known pulmonary toxicities, the cumulative total dose, the addition of radiotherapy, and the use of high doses of cyclophosphamide. CONCLUSIONS: Even though the frequency of pulmonary fibrosis in patients treated with cyclophosphamide-based chemotherapy regimens is low, the presence of dyspnea and an interstitial pattern in a patient makes it necessary to consider that possible drug toxicity. The open lung biopsy is the most accurate diagnostic technique for these cases. The discontinuation of cyclophosphamide and treatment with corticosteroids is usually followed by clinical recovery in approximately 50% of patients and, in some cases, reversal of the lung injury.

Open Lung Biopsy

1981 ◽  
Vol 12 (2) ◽  
pp. 87-94 ◽  
Author(s):  
Jerrold L. Abraham
Keyword(s):  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Open Lung
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