scholarly journals Intravenous immunoglobulin in COVID-19 associated Guillain–Barré syndrome in pregnancy

2021 ◽  
Vol 14 (5) ◽  
pp. e242365
Author(s):  
Jao Jarro Garcia ◽  
Christian Wilson Turalde ◽  
Marjorie Anne Bagnas ◽  
Veeda Michelle Anlacan
Keyword(s):  
Intravenous Immunoglobulin ◽  
Supportive Therapy ◽  
Pregnant Patient ◽  
Present Knowledge ◽  
Guillain Barre Syndrome ◽  
Upper Respiratory Tract ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Upper Respiratory ◽  
Guillain Barré

The COVID-19 pandemic has led to a rise in cases of Guillain-Barré syndrome (GBS). This autoimmune sequela is a manifestation of the neurotropism potential of the virus. At present, knowledge regarding the pathophysiology, clinical features, management and outcomes of the condition is still evolving. This paper presents the case of a 22-year-old pregnant patient who came in with a history of upper respiratory tract symptoms followed by acroparaesthesia and progressive ascending weakness. She was confirmed to have COVID-19 and GBS and was subsequently managed with intravenous immunoglobulin (IVIg) followed by supportive therapy. To the authors’ knowledge and based on their literature search, this is the first reported case of GBS in a COVID-19 confirmed pregnant patient who received IVIg.

scholarly journals Guillain-Barre Syndrome and COVID-19 Vaccine: A Report of Nine Patients

2021 ◽  
pp. 1-17
Author(s):  
Narges Karimi ◽  
◽  
Reza Boostani ◽  
Farzad Fatehi ◽  
Akram Panahi ◽  
...  
Keyword(s):  
Neuromuscular Disorder ◽  
Nerve Conduction Studies ◽  
Guillain Barre Syndrome ◽  
Upper Respiratory Tract ◽  
Cerebrospinal Fluid Analysis ◽  
Acute Inflammatory Demyelinating Polyneuropathy ◽  
Fluid Analysis ◽  
Guillain Barré Syndrome ◽  
Upper Respiratory ◽  
Guillain Barré

Background: Guillain-Barre syndrome (GBS) is an autoimmune acute inflammatory demyelinating polyneuropathy usually elicited by an upper respiratory tract infection. Several studies reported GBS associated with coronavirus-2019 (COVID-19) infection. In this study, we describe nine GBS patients following the COVID-19 vaccine. Methods: In this study, nine patients introduce from six referral centers of neuromuscular disorder in Iran between April 8 and June 20, 2021. Four patients received the Sputnik V, three patients administrated the Sinopharm, and two patients received the AstraZeneca vaccine. All patients were diagnosed with GBS, including nerve conduction studies and/or cerebrospinal fluid analysis. Results: The median age of the patients was 54.22 years (range, 26-87 years), and seven patients were male. The patients were treated with intravenous immunoglobulin (IVIg) or plasma exchange (PLEX). All patients were discharged with some improvement. Conclusion: The link between the COVID-19 vaccine and GBS is not well understood. Given the prevalence of GBS in the general population, this association may be coincidental. Therefore, more studies are needed to investigate a causal relationship.

077 Recurrent guillain-barre syndrome

2018 ◽  
Vol 89 (6) ◽  
pp. A31.2-A31
Author(s):  
Wai Foong Hooi ◽  
Elspeth Hutton ◽  
Bruce Day
Keyword(s):  
Intravenous Immunoglobulin ◽  
Lower Limbs ◽  
Guillain Barre Syndrome ◽  
Sensory Loss ◽  
Viral Gastroenteritis ◽  
List Type ◽  
Upper Respiratory Tract ◽  
Clin Neurol ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

IntroductionRecurrent Guillain-Barre syndrome (GBS) is very rare. It occurs in 2% to 5% of GBS patients. It is unclear as to why some patients have a recurrence and whether this occurs more frequently in a distinct group of patients. We report a case of a 75 year old man who had five discreet attacks of GBS in 30 years. He had an excellent response to intravenous immunoglobulin (IVIG) and achieved full clinical recovery after each attack.CaseA 75 year old man presented to the hospital with progressive ascending pattern of numbness and weakness in upper and lower limbs. This was in the setting of 10 days history of upper respiratory tract infective (URTI) symptoms. Neurological examination revealed distal sensory loss and distal weakness in upper and lower limbs. Deep tendon reflexes were absent. Nerve conduction studies showed features in keeping with GBS. He was treated with 5 days of intravenous immunoglobulin (IVIG) with significant improvement. Interestingly, this was on the background of having had 4 previous attacks of GBS in 1986 (preceded by acute gout), 1997 (preceded by the flu), 2010 (preceded by small bowel obstruction) and 2016 (preceded by viral gastroenteritis). He responded to IVIG each time and returned to his premorbid level function promptly after each attack.ConclusionRecurrent GBS is rare. It is important for clinician to be able to distinguish between recurrent GBS, treatment related fluctuations (GBS-TRF) and chronic inflammatory demyelinating polyneuropathy as the treatment and outcomes are different for each of these conditions.References. Kuitwaard K, Van Koningsveld R, Ruts L, Jacobs B, Van Doorn P. Recurrent Guillain Barre Syndrome. J Neurol Neurosurg Psychiatry2009;80:56–59.. Pyun SY, Jeong JH, Bae JS. Recurrent Guillain-Barré syndrome presenting stereotypic manifestations, positive antiganglioside antibodies, and rapid recovery. Clin Neurol Neurosurg2015Dec;139:230–3.. Mossberg N, Nordin M, Movitz C, Nilsson S, Hellstrand K, Bergström T, Andersson B, Andersen O. The recurrent Guillain-Barré syndrome: A long-term population-based study. Acta Neurol Scand2012Sep;126(3):154–61.

scholarly journals Guillain-Barré syndrome associated with COVID-19 disease

2020 ◽  
Vol 13 (9) ◽  
pp. e237215 ◽  
Author(s):  
Sindhuja Korem ◽  
Haresh Gandhi ◽  
Decerie Baculi Dayag
Keyword(s):  
Cerebrospinal Fluid ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Guillain Barre Syndrome ◽  
Upper Respiratory Tract ◽  
Cerebrospinal Fluid Analysis ◽  
Fluid Analysis ◽  
Guillain Barré Syndrome ◽  
Upper Respiratory ◽  
Guillain Barré

Clinical manifestations of COVID-19 are known to be variable with growing evidence of nervous system involvement. In this case report, we describe the symptoms of a patient infected with SARS-CoV-2 whose clinical course was complicated with Guillain-Barré syndrome (GBS). We present a case of a 58-year-old woman who was initially diagnosed with COVID-19 pneumonia due to symptoms of fever and cough. Two weeks later, after the resolution of upper respiratory tract symptoms, she developed symmetric ascending quadriparesis and paresthesias. The diagnosis of GBS was made through cerebrospinal fluid analysis and she was successfully treated with intravenous immunoglobulin administration.

scholarly journals COVID-19 and Guillain-Barre Syndrome - a Case report

2020 ◽  
Author(s):  
Amira Sidig ◽  
Khabab Abbasher ◽  
Mutaz F. Digna ◽  
Mohamed Elsayed ◽  
Hussien Abbasher ◽  
...  
Keyword(s):  
Brain Mri ◽  
Guillain Barre Syndrome ◽  
Upper Respiratory Tract ◽  
Limb Weakness ◽  
Guillain Barré Syndrome ◽  
Progressive Respiratory Failure ◽  
Chest X Ray ◽  
Upper Respiratory ◽  
Guillain Barré ◽  
Chest Ct Scan

Abstract Coronaviruses are a family of related viruses that cause diseases in mammals and avians. Guillain-Barre syndrome is a rare disorder in which the body's immune system attacks peripheral nerves.The case:A 65 years old Sudanese male with no diabetes mellitus or hypertension present to the clinic; On examination, he has upper and lower limb weakness (quadriplegia). The condition was preceded by upper respiratory tract infection. Chest X-ray showed features of pneumonia Chest CT scan showed multiple bilateral ground-glass opacities and consolidation typical of COVID-19 pneumonia. Brain MRI was normal. The COVID-19 nasal swab test was positive. Nerve conduction study showed evidence of polyradiculopathies with dominant demyelination supporting the diagnosis of Guillain-Barre syndrome. The patients died after seven days; because of progressive respiratory failure.

scholarly journals An Unusual Case of Recurrent Guillain-Barre Syndrome of a Different Subtype Five Years after Initial Diagnosis

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
M. Dy ◽  
R. L. Leshner ◽  
J. R. Crawford
Keyword(s):  
Intravenous Immunoglobulin ◽  
Nerve Root ◽  
Conduction Block ◽  
Initial Presentation ◽  
Guillain Barre Syndrome ◽  
Fluid Analysis ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Sensory Responses ◽  
Guillain Barré

We present a case of a previously healthy 17-year-old girl with history of Guillain-Barre Syndrome 5 years after initial presentation who presented with bilateral lower extremity pain, worsening dysphagia, subsequent weakness, and decreased reflexes. Cerebrospinal fluid analysis had a prominent lymphocytic pleocytosis. MRI of spine showed significant anterior nerve root enhancement. Electromyogram demonstrated a mild axonal greater than demyelinating motor polyneuropathy and intact sensory responses, with no evidence of conduction block or temporal dispersion, unlike her first presentation that revealed a demyelinating polyneuropathy. The patient recovered with mild subjective weakness following 5 days of intravenous immunoglobulin treatment. This case represents a recurrence of a predominantly motor variant polyradiculoneuropathy distinct from the initial presentation with a lymphocytic predominant CSF pleocytosis, nerve root enhancement on MRI spine, and rapid recovery following treatment with intravenous immunoglobulin.

Guillain-Barre Syndrome in a Case of Typhoid Fever: an Uncommon Association

2021 ◽  
Vol 32 (2) ◽  
pp. 142-144
Author(s):  
Abdul Basit Ibne Momen ◽  
Furial Quraishi Twinkle ◽  
Aminur Rahman ◽  
Firoz Ahmed Quraishi
Keyword(s):  
Case Report ◽  
Blood Culture ◽  
Typhoid Fever ◽  
Intravenous Immunoglobulin ◽  
Case Reports ◽  
Neurological Complication ◽  
Guillain Barre Syndrome ◽  
Intravenous Antibiotics ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain-Barre syndrome (GBS) following typhoid is extremely uncommon and only few case reports are available in literature. The importance of this case report is to highlight upon the fact that a diagnosis of GBS should always be kept in mind whenever a patient of typhoid fever develops weakness. We report a young girl with blood culture proven typhoid fever that developed this very rare neurological complication quite early in the course of the disease. Following treatment with intravenous antibiotics and intravenous immunoglobulin, she was improved. Bangladesh J Medicine July 2021; 32(2) : 142-144

scholarly journals Study on Guillain-Barré Syndrome in A Tertiary Level Military Hospital

2021 ◽  
Vol 16 (2) ◽  
pp. 44-46
Author(s):  
Md Helal Uddin ◽  
ATM Humayun Kabir ◽  
Md Ismail Chowdhury ◽  
Farzana Zafreen
Keyword(s):  
Mechanical Ventilation ◽  
Electrophysiological Study ◽  
Laboratory Data ◽  
Guillain Barre Syndrome ◽  
Military Hospital ◽  
Upper Respiratory Tract ◽  
Intravenous Immunoglobulin Therapy ◽  
Number Of Patients ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Introduction: Guillain-Barre Syndrome (GBS) is an acute, frequently severe and fulminant polyradiculopathy that is autoimmune in nature and that causes acute neuromascular failure. The condition is quite common in Bangladesh. GBS is an autoimmune and post-infectious immune disease. Objectives: To see the different presentation and outcome of GBS in combined military hospital (CMH) Dhaka. Materials and Methods: This was a retrospective observational study conducted on all the GBS patients admitted in the Neurology Ward of CMH Dhaka from January 2005 to July 2010. Total 25 patients clinical and laboratory data including CSF analysis, electrophysiological study data were collected from patients’ case sheet. Results: Among the 25 GBS patients male was 22 (88%) and female 03(12%) and most common age group affected was 31-40 years comprising of 09(36%) patients. The most common types of GBS patients were acute inflammatory demyelinating polyneuropathy (AIDP) 17(68%) patients and 10(40%) patients were found to have history of upper respiratory tract infection (URTI). Albuminocytological dissociation was found in 20(80%) patients in CSF study. Intravenous immunoglobulin therapy was given to 13(52%) patients, of them 09(36%) patient needed mechanical ventilation; rest 12(48%) patients were treated conservatively. The final outcome was full recovery 22(88%) patients, 02(8%) patients had residual disability and only one patient died after 2 years of GBS. Conclusion: GBS is an important cause of peripheral neuropathy. Patient should be monitored carefully because a significant number of patients ultimately require mechanical ventilation for respiratory failure which may be of sudden onset. JAFMC Bangladesh. Vol 16, No 2 (December) 2020: 44-46

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