Systemic lupus erythematosus presenting with lymphoid interstitial pneumonia as an initial manifestation

2021 ◽  
Vol 14 (12) ◽  
pp. e243539
Author(s):  
Akiko Maeda ◽  
Mitsuyo Kinjo ◽  
Kiyoshi Kinjo ◽  
Tomoo Kishaba
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Interstitial Pneumonia ◽  
Lupus Erythematosus ◽  
Lung Biopsy ◽  
Cervical Lymphadenopathy ◽  
Systemic Lupus ◽  
Initial Manifestation ◽  
Travel History ◽  
Double Stranded Dna ◽  
Multiple Lung Nodules

A 25-year-old woman with an extensive travel history developed chronic cough and multiple lung nodules. The lung biopsy revealed lymphoid interstitial pneumonia. The patient later developed cervical lymphadenopathy, arthritis and livedo reticularis, then systemic lupus erythematosus was diagnosed with positive double-stranded DNA and low complement. The patient’s symptoms responded to prednisolone and azathioprine.

scholarly journals Clinical profile of systemic lupus erythematosus among children less than 12 years

2018 ◽  
Vol 5 (2) ◽  
pp. 343
Author(s):  
Senthil Kumar Andy ◽  
Elayaraja Kandasamy
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Damage Index ◽  
Organ Damage ◽  
Clinical Profile ◽  
Connective Tissues ◽  
Systemic Lupus ◽  
Initial Manifestation ◽  
Double Stranded Dna

Background: Systemic lupus erythematosus (SLE) is an episodic multisystem autoimmune disease characterized by widespread inflammation of blood vessels and connective tissues and by the presence of antinuclear antibodies especially antibodies to native double stranded DNA. The aim was to study the clinical profile of SLE among children less than 12 years attending an urban referral hospital, SLEDAI scoring at onset and follow up at 1 year and SLICC/ACR damage index at 1 year.Methods: A descriptive, prospective and observational study was conducted in Medical, Nephrology, Rheumatology OPD wards, in ICH and HC, from November 2007 to August 2009 among all children diagnosed to have SLE. Results: In this study there were 50 cases over the last 2 years. Majority of the children were diagnosed within a year of their initial manifestation. The mean age at the time of onset of symptoms was 7.94 years. Female to male ratio in our study is 2.5:1.Conclusions: Efforts should be directed in diagnosing at earlier stage itself for better outcome. SLEDAI and SLICC/ACR DI can be incorporated in routine follow up to detect mild to moderate and severe flare and extent of organ damage.

Acute pericardial tamponade: The initial manifestation of systemic lupus erythematosus with Graves’ hyperthyroidism

Lupus ◽  
2021 ◽  
pp. 096120332110047
Author(s):  
Muming Yu ◽  
Yulei Gao ◽  
Heng Jin ◽  
Songtao Shou
Keyword(s):  
Myocardial Infarction ◽  
Systemic Lupus Erythematosus ◽  
Female Patient ◽  
Lupus Erythematosus ◽  
Pericardial Tamponade ◽  
Medical Emergency ◽  
Systemic Lupus ◽  
Initial Manifestation ◽  
Life Threatening ◽  
Obstructive Shock

Acute pericardial tamponade, which can cause obstructive shock, is a serious life-threatening medical emergency that can be readily reversed by timely identification and appropriate intervention. Acute pericardial tamponade can occur for a number of reasons, including idiopathic, malignancy, uremia, iatrogenic, post-myocardial infarction, infection, collagen vascular, hypothyroidism, and others. Systemic lupus erythematosus (SLE) and hyperthyroidism associated with pericardial tamponade are rarely reported. Here, we report the case of a 20-year-old female patient was final diagnosed of SLE with Graves’ hyperthyroidism.

Hemophagocytic Syndrome as the Initial Manifestation of Systemic Lupus Erythematosus

2014 ◽  
Vol 10 (5) ◽  
pp. 321-324 ◽  
Author(s):  
César Antonio Egües Dubuc ◽  
Miren Uriarte Ecenarro ◽  
Carlos Meneses Villalba ◽  
Vicente Aldasoro Cáceres ◽  
Iñaki Hernando Rubio ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Hemophagocytic Syndrome ◽  
Systemic Lupus ◽  
Initial Manifestation

Inhibition of Adenovirus DNA Synthesis In Vitro by Sera from Patients with Systemic Lupus Erythematosus

1982 ◽  
Vol 2 (12) ◽  
pp. 1492-1500
Author(s):  
Marshall S. Horwitz ◽  
Beth R. Friefeld ◽  
Harold D. Keiser
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Synthesis ◽  
Lupus Erythematosus ◽  
Inhibitory Activity ◽  
Antinuclear Antibodies ◽  
Dna Binding Protein ◽  
Systemic Lupus ◽  
Double Stranded Dna ◽  
The Individual

Sera containing antinuclear antibodies from patients with systemic lupus erythematosus (SLE) and related disorders were tested for their effect on the synthesis of adenovirus (Ad) DNA in an in vitro replication system. After being heated at 60°C for 1 h, some sera from patients with SLE inhibited Ad DNA synthesis by 60 to 100%. Antibodies to double-stranded DNA were present in 15 of the 16 inhibitory sera, and inhibitory activity copurified with anti-double-stranded DNA in the immunoglobulin G fraction. These SLE sera did not inhibit the DNA polymerases α, β, γ and had no antibody to the 72,000-dalton DNA-binding protein necessary for Ad DNA synthesis. The presence of antibodies to single-stranded DNA and a variety of saline-extractable antigens (Sm, Ha, nRNP, and rRNP) did not correlate with SLE serum inhibitory activity. Methods previously developed for studying the individual steps in Ad DNA replication were used to determine the site of inhibition by the SLE sera that contained antibody to double-stranded DNA. Concentrations of the SLE inhibitor that decreased the elongation of Ad DNA by greater than 85% had no effect on either the initiation of Ad DNA synthesis or the polymerization of the first 26 deoxyribonucleotides.

scholarly journals Is recurrent Kikuchi-Fujimoto disease a precursor to systemic lupus erythematosus?

2019 ◽  
Vol 57 (1) ◽  
pp. 72-77
Author(s):  
Taro Horino ◽  
Osamu Ichii ◽  
Yoshio Terada
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Clinical Entity ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Necrotizing Lymphadenitis

Abstract Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting disease characterized by cervical lymphadenopathy and fever. Since KFD was first reported in 1972, the validity of this clinical entity has been controversial and its aetiology remains unknown. Herein, we report a case of a patient with KFD, which was believed to be associated with systemic lupus erythematosus.

Poster 327: Acute Paralysis as the Initial Manifestation of Systemic Lupus Erythematosus: A Case Report

PM&R ◽  
2009 ◽  
Vol 1 ◽  
pp. S246-S246
Author(s):  
Jasmine Martinez-Barrizonte ◽  
Kresimir Banovac ◽  
Alberto Martinez-Arizala
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Initial Manifestation

Chorea as an Initial Manifestation of Systemic Lupus Erythematosus

1984 ◽  
Vol 23 (5) ◽  
pp. 298-300 ◽  
Author(s):  
Osamu Arisaka ◽  
Kaoru Obinata ◽  
Hidekuni Sasaki ◽  
Madoka Arisaka ◽  
Kenichiro Kaneko
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Initial Manifestation
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