Polymorphous adenocarcinoma of the submandibular gland

2021 ◽  
Vol 14 (8) ◽  
pp. e244218
Author(s):  
Shiv Rajan ◽  
Ajay Kumar Singh ◽  
Sumaira Qayoom ◽  
Palavalasa Niranjan ◽  
Deep Chakrabarti
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Major Salivary Gland ◽  
Salivary Gland Tumours ◽  
Polymorphous Adenocarcinoma ◽  
Uncommon Case ◽  
Criteria For Diagnosis ◽  
Rare Malignancy

Polymorphous adenocarcinoma (PA) of the salivary glands is a rare malignancy that predominantly affects the minor salivary glands of the palate. Major salivary gland involvement is rare (<5%). The submandibular gland is a highly unusual location for this tumour. Recently, the WHO has updated the classification of salivary gland tumours in which the PA subtype has been modified. We report a very uncommon case of a classical variant of PA involving the submandibular gland in a 49-year-old woman managed at our institute and discuss the most recent pathological criteria for diagnosis, management strategy and prognosis of PA.

Two malignant salivary gland tumours of different type in one patient

1994 ◽  
Vol 108 (9) ◽  
pp. 798-800 ◽  
Author(s):  
A. Hosni ◽  
C. Fisher ◽  
P. Rhŷ-Evans
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histological Type ◽  
Salivary Gland Tumours ◽  
Adenoid Cystic ◽  
The Right ◽  
Left Parotid Gland

AbstractThe synchronous or metachronous occurrence of two tumours of the salivary glands in one patient is rare. These are mainly benign and of the same histological type. Here we report a 56-year-old man who developed a mucoepidermoid tumour of the left parotid gland four years after diagnosis of adenoid cystic carcinoma of the right submandibular gland. This combination of neoplasms has not to our knowledge been reported before.

scholarly journals Salivary gland tumours - a three years experience at King Edward Medical College, Lahore

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Asmaa Qureshi ◽  
Khalilur Rehman ◽  
Sohail Husain ◽  
Nasirul Hasan Khawaja ◽  
Ghulam Rasood Qureshi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Single Case ◽  
Malignant Neoplasms ◽  
Salivary Gland Tumours ◽  
Medical College ◽  
Common Location ◽  
Female Predominance

Salivary gland tumours make an important part of oral & maxillofacial pathology. Only few studies have been done in Pakistani population. The aim of this study was to describe morphological types of salivary gland tumours diagnosed at King Edward Medical College/ Mayo Hospital, Lahore during the years 1999-2001 and to compare their demographic data with those previously published. Material & Methods: This descriptive cross-sectional study was carried out at King Edward Medical College/ Mayo Hospital, Lahore. It reports 117 cases of salivary gland tumours diagnosed at Pathology Department during 1999-2001. Results: Of the 128 specimens of salivary glands, 117(91.4%) were confirmed as salivary neoplasms. Out of them, 62.7% were benign and 37.6% malignant and a slight female predominance (58.1%) was found. The most common location was the parotid gland (65.8%) followed by minor salivary glands (19.6%). Majority oft he t tumours was diagnosed during 3rd to 5 decades of life. Median age for benign tumours was 33 years (range 1-78) and a female predominance (58.9%) was seen again. Median age for malignant neoplasms was 45 years (range 9-70) with a female predilection ( 56.8%). However, 4 out o f 5 patients with Warthin`s tumour were men. Pleomorphic adenoma was the most frequent tumour (51.3%), followed by mucoepidermoid carcinoma (25.6%), adenoid cystic carcinoma (7.7)), Warthin`s tumour (4.3%) and monomorphic adenoma (2.6%). Two cases each of oncytoma & adenocarcinoma were recorded. Rare categories (single case each) of salivary tumours included lipoma, acinic cell carcinoma, basal cell adenoma, capillary haemangioma, metastatic carcinoma and non Hodgkin`s lymphoma. Conclusion: The principal site of salivary tumours was the parotid gland and females were most affected. Pleomorphic adenoma was the most frequent finding. The results of this study are comparable with other studies.

Salivary gland diseases

2018 ◽  
Author(s):  
Max Robinson ◽  
Keith Hunter ◽  
Michael Pemberton ◽  
Philip Sloan
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Neck Region ◽  
Normal Function ◽  
Minor Salivary Glands ◽  
Flow Rates ◽  
Endocrine Disturbances ◽  
Systemic Factors ◽  
Gland Function

The salivary glands consist of three paired major glands—parotid, sub­mandibular, and sublingual—and the countless minor salivary glands found in almost every part of the oral cavity, except the gingiva and anterior regions of the hard palate. The secretion of saliva is essential for the normal function and health of the mouth, and disorders of salivary gland function predispose to oral disease. Functional disorders in salivary secretion may be associated with primary salivary gland disease but in other cases are a consequence of systemic factors, such as medi­cations, endocrine disturbances, and neurological disease, which are discussed in Chapter 10. Developmental anomalies of the salivary glands are rare. Aplasia of one or more major glands and atresia of one or more major salivary gland ducts have been reported. Congenital aplasia of the parotid gland may be associated with other facial abnormalities, e.g. ectodermal dysplasia, mandibulofacial dysostosis, and hemifacial microsomia. Heterotopic salivary tissue has been reported from a variety of sites in the head and neck region, the most frequent being its inclusion at the angle, or within the body, of the mandible, called a Stafne bone cavity. It is usually an incidental radiological finding and appears as a round or oval, well-demarcated radiolucency between the premolar region and angle of the jaw, and is typically located beneath the inferior dental canal. The radiographic appearances are due to a saucer-shaped depression or concavity of varying depth on the lingual aspect of the mandible, which contains salivary tissue in continuity with the submandibular gland. Accessory parotid tissue within the cheek or masseter muscle is rela­tively common and is subject to the same diseases that may affect the main gland. Age changes can be detected in both major and minor salivary glands. Reduction in the weights of submandibular and parotid glands has been reported with increasing age, associated in the submandibular gland with an age-dependent reduction in flow rates. By contrast, sev­eral studies have demonstrated that there is no significant reduction in parotid flow rates in the elderly.

scholarly journals Unusually Large Submandibular Sialoliths: Report of Two Cases

2009 ◽  
Vol 03 (02) ◽  
pp. 135-139 ◽  
Author(s):  
Meryem Toraman Alkurt ◽  
Ilkay Peker
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histopathological Examination ◽  
Floor Of The Mouth ◽  
Common Diseases ◽  
Wharton’S Duct

ABSTRACTSialoliths are the most common diseases of the salivary glands. They may occur in any of the salivary gland ducts but are most common in Wharton’s duct and the submandibular gland. This report presents clinical and radiographical signs of two unusually large sialoliths. There were painless swellings on the floor of the mouth in both cases. Radiographical examination revealed large irregular radioopaque mass superimposed right canine and premolar areas. After the lesions were removed, histopathological examination was performed and lesions were diagnosed as sialoliths. (Eur J Dent 2009;3:135-139)

scholarly journals Bilateral Basal Cell Adenocarcinoma of the Parotid Gland: In a Recipient of Kidney Transplant

2010 ◽  
Vol 3 ◽  
pp. CPath.S3303 ◽  
Author(s):  
Mari Markkanen-Leppänen ◽  
Antti A. Mäkitie ◽  
Fabricio Passador-Santos ◽  
Ilmo Leivo ◽  
Jaana Hagström
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Basal Cell ◽  
Continuous Administration ◽  
Cell Adenoma ◽  
Basal Cell Adenocarcinoma ◽  
Salivary Gland Tumours ◽  
Important Differential Diagnosis ◽  
Salivary Gland Malignancy

We report a rare case of bilateral basal cell adenocarcinoma (BcAC) of the parotid gland in a male patient 30 years after kidney transplantation and continuous administration of immunosuppressive therapy. BcAC is a salivary gland malignancy first recognized as a distinct neoplastic entity in WHO classification of salivary gland tumours in 1991. Over 90% of BcACs are detected in the parotid gland. The most important differential diagnosis is basal cell adenoma. Infiltrative growth is the distinguishing feature of BcAC. Administration of immunosuppressive medication to this patient for three decades may have contributed to development of this rare neoplasia. To our knowledge, similar cases of BcAC have not been reported previously.

scholarly journals Initial Report of a Case of Carcinosarcoma of the Supraglottis

2000 ◽  
Vol 79 (5) ◽  
pp. 384-387 ◽  
Author(s):  
Joel A. Ernster ◽  
Douglas W. Franquemont ◽  
James P. Sweeney
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Single Case ◽  
Minor Salivary Gland ◽  
Upper Airway ◽  
Surface Epithelium ◽  
Initial Report ◽  
First Case ◽  
Special Mention ◽  
Rare Malignancy

Minor salivary gland carcinosarcoma is a rare malignancy with an ominous prognosis. This report recounts a single case of supraglottic minor salivary gland carcinosarcoma that was treated aggressively. We discuss the peculiarities of the histology, with special mention of the distinction that must be made between mucosal-origin and salivary-gland-origin carcinosarcoma. Carcinosarcomas are aggressive regardless of their origin, but differentiating their origin is important because the prognosis is worse for those that arise in salivary glands than for those that originate in the surface epithelium. This report adds to the literature a new case of minor salivary-gland-origin carcinosarcoma involving the upper airway. It is the first case we could identify in which the supraglottis was involved.

Patterns of Care and Outcome of Clear Cell Carcinoma of the Head and Neck

2019 ◽  
Vol 161 (1) ◽  
pp. 98-104 ◽  
Author(s):  
Jamie Oliver ◽  
Peter Wu ◽  
Clifford Chang ◽  
Dylan Roden ◽  
Binhuan Wang ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Tumor Grade ◽  
Low Grade ◽  
Major Salivary Gland ◽  
Positive Margins

Objective Clear cell carcinoma (CCC) is a rare salivary gland malignancy, believed to be generally low grade. We investigated CCC epidemiology and clinical behavior, using the National Cancer Database (NCDB). Study Design Retrospective cohort study. Setting NCDB. Subjects and Methods All CCCs of the salivary glands were selected between 2004 and 2015. Patient demographics, tumor characteristics, treatments, and survival were analyzed. Cox regression analyses were performed in treated patients. Results We identified 268 patients with CCC. Median age was 61 (21-90) years. Most were female (145, 54%). The most common site was oral cavity (119, 44%), followed by major salivary glands (68, 25%) and oropharynx (41, 15%). Most tumors were low grade (81, 68%) and stages I to II (117, 60.6%). Nodal (36, 17.5%) and distant metastases (6, 2.4%) were rare. Most were treated by surgery alone (134, 50.0%), followed by surgery and radiotherapy (69, 25.7%). Five-year overall survival (OS) was 77.6% (95% CI, 71.4%-84.2%). In univariate analysis, older age, major salivary gland and sinonasal site, stages III to IV, high grade, and positive margins were associated with worse OS. In multivariate analysis, only high tumor grade (hazard ratio [HR], 5.76; 95% CI, 1.39-23.85; P = .02), positive margins (HR, 4.01; 95% CI, 1.20-13.43; P = .02), and age ≥60 years (HR, 3.45; 95% CI, 1.39-8.55; P = .01) were significantly associated with OS. Conclusion We report the largest series of clear cell carcinomas of the head and neck. Outcomes are generally favorable following surgical-based treatments. In this series, pathologic tumor grade is associated with worse survival. Routine evaluation and reporting of tumor grade might better guide physicians in recommending appropriate treatments in this rare malignancy.

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