Initial Report of a Case of Carcinosarcoma of the Supraglottis

Minor salivary gland carcinosarcoma is a rare malignancy with an ominous prognosis. This report recounts a single case of supraglottic minor salivary gland carcinosarcoma that was treated aggressively. We discuss the peculiarities of the histology, with special mention of the distinction that must be made between mucosal-origin and salivary-gland-origin carcinosarcoma. Carcinosarcomas are aggressive regardless of their origin, but differentiating their origin is important because the prognosis is worse for those that arise in salivary glands than for those that originate in the surface epithelium. This report adds to the literature a new case of minor salivary-gland-origin carcinosarcoma involving the upper airway. It is the first case we could identify in which the supraglottis was involved.

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Basal Cell Adenocarcinoma of the Minor Salivary Glands Involving Palate and Maxillary Sinus

Journal of Clinical Imaging Science ◽

10.4103/2156-7514.112799 ◽

2013 ◽

Vol 3 ◽

pp. 4 ◽

Cited By ~ 6

Author(s):

Prathi Venkata Sarath ◽

N. Kannan ◽

Rajendra Patil ◽

Rakesh Kumar Manne ◽

Beeraka Swapna ◽

...

Keyword(s):

Salivary Gland ◽

Maxillary Sinus ◽

Salivary Glands ◽

Basal Cell ◽

Minor Salivary Gland ◽

Surgical Excision ◽

Good Prognosis ◽

Minor Salivary Glands ◽

Basal Cell Adenocarcinoma ◽

First Case

Basal cell adenocarcinoma (BCAC) is a rare neoplasm accounting for only 2.9% of all salivary gland neoplasms. BCAC involving palatal minor salivary glands are exceedingly rare, and only 10 cases have been reported in the literature. The treatment of choice is surgical excision. Here, we report a case of a 55-year-old male patient with massive BCAC of palatal minor salivary gland extending into the maxillary sinus. This is the first case of BCAC treated by radiotherapy followed by chemotherapy. A follow-up check conducted after 14-months showed good prognosis.

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Terminal duct adenocarcinomas of the parotid gland

The Journal of Laryngology & Otology ◽

10.1017/s0022215100130452 ◽

1995 ◽

Vol 109 (5) ◽

pp. 466-468 ◽

Cited By ~ 18

Author(s):

Bonnie L. Kemp ◽

John G. Batsakis ◽

Adel K. El-Naggar ◽

Sophia N. Kotliar ◽

Mario A. Luna

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Salivary Glands ◽

Minor Salivary Gland ◽

Low Grade ◽

Minor Salivary Glands ◽

Biological Behaviour ◽

Parotid Neoplasms ◽

Clinicopathological Study

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

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Salivary gland tumours - a three years experience at King Edward Medical College, Lahore

Annals of King Edward Medical University ◽

10.21649/akemu.v10i2.1207 ◽

2016 ◽

Vol 10 (2) ◽

Author(s):

Asmaa Qureshi ◽

Khalilur Rehman ◽

Sohail Husain ◽

Nasirul Hasan Khawaja ◽

Ghulam Rasood Qureshi ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Single Case ◽

Malignant Neoplasms ◽

Salivary Gland Tumours ◽

Medical College ◽

Common Location ◽

Female Predominance

Salivary gland tumours make an important part of oral & maxillofacial pathology. Only few studies have been done in Pakistani population. The aim of this study was to describe morphological types of salivary gland tumours diagnosed at King Edward Medical College/ Mayo Hospital, Lahore during the years 1999-2001 and to compare their demographic data with those previously published. Material & Methods: This descriptive cross-sectional study was carried out at King Edward Medical College/ Mayo Hospital, Lahore. It reports 117 cases of salivary gland tumours diagnosed at Pathology Department during 1999-2001. Results: Of the 128 specimens of salivary glands, 117(91.4%) were confirmed as salivary neoplasms. Out of them, 62.7% were benign and 37.6% malignant and a slight female predominance (58.1%) was found. The most common location was the parotid gland (65.8%) followed by minor salivary glands (19.6%). Majority oft he t tumours was diagnosed during 3rd to 5 decades of life. Median age for benign tumours was 33 years (range 1-78) and a female predominance (58.9%) was seen again. Median age for malignant neoplasms was 45 years (range 9-70) with a female predilection ( 56.8%). However, 4 out o f 5 patients with Warthin`s tumour were men. Pleomorphic adenoma was the most frequent tumour (51.3%), followed by mucoepidermoid carcinoma (25.6%), adenoid cystic carcinoma (7.7)), Warthin`s tumour (4.3%) and monomorphic adenoma (2.6%). Two cases each of oncytoma & adenocarcinoma were recorded. Rare categories (single case each) of salivary tumours included lipoma, acinic cell carcinoma, basal cell adenoma, capillary haemangioma, metastatic carcinoma and non Hodgkin`s lymphoma. Conclusion: The principal site of salivary tumours was the parotid gland and females were most affected. Pleomorphic adenoma was the most frequent finding. The results of this study are comparable with other studies.

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An unusual pleomorphic adenoma

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-86372014000300000141930 ◽

2014 ◽

Vol 62 (3) ◽

pp. 319-324

Author(s):

Christiano Sampaio QUEIROZ ◽

Roberto Almeida de AZEVEDO ◽

Antonio Irineu TRINDADE NETO ◽

Caetano Guilherme Carvalho PONTES ◽

Rafael de Queiroz MOURA

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Histopathological Examination ◽

Minor Salivary Gland ◽

Surgical Excision ◽

Biological Behavior ◽

Surgical Removal ◽

Minor Salivary Glands ◽

Recommended Treatment

Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. It constitutes approximately 90% of all benign salivary gland lesions and the parotid is the most affected location. When the minor salivary glands are affected, it mostly occurs at the junction of the hard and soft palates. The diagnosis is complex because of the great histological variety and biological behavior of this tumor, a histopathological examination being essential. The recommended treatment is surgical excision. For lesions located superficially in the parotid gland, superficial parotidectomy - identifying and preserving the facial nerve - is necessary. Lesions in the palate or gums sometimes demand a margin of safety, being excised below the periosteum, including the overlying mucosa. With correct surgical removal, the prognosis is excellent. The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing the most important aspects of this pathology.

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Pleomorphic Adenoma of Minor Salivary Gland in Buccal Mucosa: an Uncommon Finding

Dental Journal of Advance Studies ◽

10.1055/s-0038-1672013 ◽

2015 ◽

Vol 03 (01) ◽

pp. 047-050

Author(s):

Gourav Ahuja ◽

Jaideep Marya ◽

Poonam Sood

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Buccal Mucosa ◽

Minor Salivary Gland ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Minor Salivary Glands ◽

Diverse Range ◽

Neck Tumors

AbstractSalivary gland tumors account for less than 3% of the head and neck tumors. Among various salivary gland tumors, pleomorphic adenoma is most common and accounts for 60- 70% of the benign tumors of salivary glands. However, the involvement of minor salivary glands of buccal mucosa is extremely uncommon and reported to be 4% only. Salivary glands may present with a diverse range of lesions presenting a challenge to even the most experienced clinician. We report two rare cases of pleomorphic adenoma of minor salivary glands of buccal mucosa in a 45 year old female and 70 years old male respectively. It includes clinical features, diagnosis and treatment of the tumor.

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Clear cell carcinoma arising in pleomorphic adenoma of the minor salivary gland

The Journal of Laryngology & Otology ◽

10.1017/s0022215100110096 ◽

1989 ◽

Vol 103 (8) ◽

pp. 789-791 ◽

Cited By ~ 14

Author(s):

Jerzy Klijanienko ◽

Christian Micheau ◽

Guy Schwaab ◽

Patrick Marandas ◽

Sam Friedman

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

English Literature ◽

Relevant Literature ◽

Minor Salivary Gland ◽

A Minor

AbstractMalignant change arising in pleomorphic adenoma of the salivary glands is uncommon, with a reported incidence of 2–10 per cent.Only one case where a pleomorphic adenoma became a clear cell carcinoma appears to have been published in the English literature. An additional case of clear cell carcinoma arising in pleomorphic adenoma of a minor salivary gland is reported and the relevant literature discussed.

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Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203195 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1460

Author(s):

Prakash Mylanahalli Doddrangaiah ◽

Bharath Kanna Karunakaran ◽

Roopa S. Mallali ◽

Afshan Fathima

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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Case report of myoepithelial carcinoma of maxillary sinus

Journal of Chitwan Medical College ◽

10.3126/jcmc.v10i1.28080 ◽

2020 ◽

Vol 10 (1) ◽

pp. 85-87

Author(s):

Ahmad Liaquat ◽

Nabeela Riaz ◽

Arun Kumar Shah

Keyword(s):

Salivary Gland ◽

Case Report ◽

Maxillary Sinus ◽

De Novo ◽

Minor Salivary Gland ◽

Myoepithelial Carcinoma ◽

Titanium Mesh ◽

Total Maxillectomy ◽

Orbital Floor Reconstruction ◽

Rare Malignancy

Myoepithelial carcinoma of the salivary gland is extremely rare malignancy. It may arise either in recurrent or pre existing pleomorphic adenoma or de novo in salivary glands. We herein present the case report of 35 years old male patient who presented to us with myoepithelial carcinoma of minor salivary gland of right maxillary sinus. Right total maxillectomy was done and orbital floor reconstruction was done with titanium mesh.

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Polymorphous adenocarcinoma of the submandibular gland

BMJ Case Reports ◽

10.1136/bcr-2021-244218 ◽

2021 ◽

Vol 14 (8) ◽

pp. e244218

Author(s):

Shiv Rajan ◽

Ajay Kumar Singh ◽

Sumaira Qayoom ◽

Palavalasa Niranjan ◽

Deep Chakrabarti

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Submandibular Gland ◽

Major Salivary Gland ◽

Salivary Gland Tumours ◽

Polymorphous Adenocarcinoma ◽

Uncommon Case ◽

Criteria For Diagnosis ◽

Rare Malignancy

Polymorphous adenocarcinoma (PA) of the salivary glands is a rare malignancy that predominantly affects the minor salivary glands of the palate. Major salivary gland involvement is rare (<5%). The submandibular gland is a highly unusual location for this tumour. Recently, the WHO has updated the classification of salivary gland tumours in which the PA subtype has been modified. We report a very uncommon case of a classical variant of PA involving the submandibular gland in a 49-year-old woman managed at our institute and discuss the most recent pathological criteria for diagnosis, management strategy and prognosis of PA.

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Analysis of Lymphocyte Monoclonality in Patients with Sjögren’s Syndrome Associated with Lymphoproliferative Disorder or Lymphoma.

Blood ◽

10.1182/blood.v104.11.4547.4547 ◽

2004 ◽

Vol 104 (11) ◽

pp. 4547-4547

Author(s):

Yasufumi Masaki ◽

Lingli Dong ◽

Hiroshi Kawabata ◽

Yuko Hirose ◽

Susumu Sugai

Keyword(s):

Salivary Gland ◽

B Cell ◽

Salivary Glands ◽

Lymphoproliferative Disorder ◽

Cell Clone ◽

Normal Population ◽

Minor Salivary Gland ◽

Pcr Amplification ◽

Cell Receptor ◽

Clonality Analysis

Abstract Purpose: Among 450 Sjögren’s syndrome (SS) patients in our hospital, we investigated 27 cases of malignant lymphoma (ML). In many reports, the risk of developing ML is higher, for example 43.8 times greater in patients with SS than in a comparable normal population in Kassan, et al, and 47.8 times greater in our Cases. Besides MALT lymphoma, other types of nodal lymphomas have been observed in patients with SS. To clarify the relationship between lymphocyte monoclonality and the development of the lymphomas in SS, we performed a clonality analysis of the tissues from salivary glands and lymphoproliferative organs. Method. Clonality analysis was applied to lymphocytes in SS-related lymphoproliferative tissues from 3 patients who had lymphoproliferative disorder and were observed sequentially. We also compared the clonality between minor salivary gland and lymphoma tissues from 6 SS patients with nodal lymphoma. PCR amplification, cloning and sequencing were performed to identify immunoglobulin heavy chain complementarity-determining region 3 (IgH-CDR3) and T cell receptor-gamma (TCR-γ) gene rearrangement. Results. In the 3 patients with sequential observation, B cell proliferation progressed from polyclonal or oligoclonal into monoclonal expansion in the salivary gland or extraglandular tissues. In one of these patients, lymphoma development was seen in the salivary gland. In all of the 6 SS patients with nodal lymphomas, the B cell clone in the salivary glands were different from those in the lymphoma tissues. Conclusion. In patients with SS, there were two patterns of lymphoma progression. One was the multi-step process in which polyclonal B cell expansion evolves into monoclonal disease in extra-nodal lymphomas in salivary or lacrimal glands. The other was the independent clonality between salivary glands and lymphomas in patients with nodal lymphomas, and SS may play a role in the development of nodal lymphoma. Considering that the microenvironments of lymph nodes and salivary glands are different, the mechanism of the development of the extra-nodal lymphomas and the nodal lymphomas may be different.

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