scholarly journals Bruch's membrane change with age.

1992 ◽  
Vol 76 (3) ◽  
pp. 166-168 ◽  
Author(s):  
A C Bird
Keyword(s):  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Membrane Change

scholarly journals Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment.

1993 ◽  
Vol 77 (7) ◽  
pp. 400-403 ◽  
Author(s):  
B. Piguet ◽  
J. A. Wells ◽  
I. B. Palmvang ◽  
R. Wormald ◽  
I. H. Chisholm ◽  
...  
Keyword(s):  
Clinical Study ◽  
Relative Role ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Age Related ◽  
Membrane Change

scholarly journals Symptomatic abnormalities of dark adaptation in patients with age-related Bruch's membrane change.

1993 ◽  
Vol 77 (9) ◽  
pp. 549-554 ◽  
Author(s):  
R L Steinmetz ◽  
R Haimovici ◽  
C Jubb ◽  
F W Fitzke ◽  
A C Bird
Keyword(s):  
Dark Adaptation ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Age Related ◽  
Membrane Change

Choroidal Perfusion Abnormality With Age-Related Bruch's Membrane Change

1990 ◽  
Vol 109 (2) ◽  
pp. 211-217 ◽  
Author(s):  
D. Pauleikhoff ◽  
J.C. Chen ◽  
I.H. Chisholm ◽  
A.C. Bird
Keyword(s):  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Perfusion Abnormality ◽  
Age Related ◽  
Choroidal Perfusion ◽  
Membrane Change

scholarly journals FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rawshan Choudhury ◽  
Nadhim Bayatti ◽  
Richard Scharff ◽  
Ewa Szula ◽  
Viranga Tilakaratna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Fate ◽  
Retinal Pigment ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Rpe Cells ◽  
Age Related

AbstractRetinal pigment epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of photoreceptor cells and hence vision. Interactions between the RPE and their basement membrane, i.e. the inner layer of Bruch’s membrane, are essential for RPE cell health and function, but the signals induced by Bruch’s membrane engagement, and their contributions to RPE cell fate determination remain poorly defined. Here, we studied the functional role of the soluble complement regulator and component of Bruch’s membrane, Factor H-like protein 1 (FHL-1). Human primary RPE cells adhered to FHL-1 in a manner that was eliminated by either mutagenesis of the integrin-binding RGD motif in FHL-1 or by using competing antibodies directed against the α5 and β1 integrin subunits. These short-term experiments reveal an immediate protein-integrin interaction that were obtained from primary RPE cells and replicated using the hTERT-RPE1 cell line. Separate, longer term experiments utilising RNAseq analysis of hTERT-RPE1 cells bound to FHL-1, showed an increased expression of the heat-shock protein genes HSPA6, CRYAB, HSPA1A and HSPA1B when compared to cells bound to fibronectin (FN) or laminin (LA). Pathway analysis implicated changes in EIF2 signalling, the unfolded protein response, and mineralocorticoid receptor signalling as putative pathways. Subsequent cell survival assays using H2O2 to induce oxidative stress-induced cell death suggest hTERT-RPE1 cells had significantly greater protection when bound to FHL-1 or LA compared to plastic or FN. These data show a non-canonical role of FHL-1 in protecting RPE cells against oxidative stress and identifies a novel interaction that has implications for ocular diseases such as age-related macular degeneration.

Bruch's membrane opening minimum rim width and retinal nerve fiber layer helps differentiate compressive optic neuropathy from glaucoma

2021 ◽  
Author(s):  
Thais de Souza Andrade ◽  
Rafael Barbosa de Araújo ◽  
Arthur Andrade do Nascimento Rocha ◽  
Luiz Guilherme Marchesi Mello ◽  
Leonardo P. Cunha ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Optic Neuropathy ◽  
Retinal Nerve Fiber Layer ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fiber Layer ◽  
Compressive Optic Neuropathy ◽  
Nerve Fiber Layer ◽  
Bruch’S Membrane Opening ◽  
Retinal Nerve Fiber

Study of the Morphological and Adhesion Properties of Collagen Fibers in the Bruch's Membrane

2005 ◽  
Vol 109 (41) ◽  
pp. 19052-19055 ◽  
Author(s):  
Shrestha Basu Mallick ◽  
Albena Ivanisevic
Keyword(s):  
Collagen Fibers ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Adhesion Properties

Cellular Processes Causing Defects in Bruch's Membrane Following Krypton Laser Photocoagulation

Ophthalmology ◽  
1986 ◽  
Vol 93 (8) ◽  
pp. 1113-1119 ◽  
Author(s):  
A. Pollack ◽  
W.J. Heriot ◽  
P. Henkind
Keyword(s):  
Laser Photocoagulation ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Cellular Processes

Comparative histogenesis of Bruch's membrane (complexus basalis)

1991 ◽  
Vol 53 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Jack V. Greiner ◽  
Thomas A. Weidman
Keyword(s):  
Bruch's Membrane ◽  
Bruch’S Membrane
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